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Medical and Surgical Treatment of Parathyroid Diseases pp 27–38Cite as

Parathyroid Physiology and Molecular Biology

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Abstract

The parathyroid hormone gene has been sequenced in more than ten different species. Phylogenetic analysis has identified an array of homologous domains associated with the synthesis, secretion, and degradation of parathyroid hormone (PTH). These studies are advancing our understanding of the molecular signaling and feedback mechanisms involved in the hormonal control of calcium and phosphate metabolism. This chapter reviews these physiologic processes at the molecular level, which serves as a solid conceptual framework for understanding the pathology discussed in later chapters.

Keywords

  • PTH
  • Regulation
  • Transcription
  • Translation
  • Secretion

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Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, 4302 W. Markham St Slot, #806, Little Rock, AR 72205-7199, USA

    Andrew M. Hinson M.D. & Brendan C. Stack Jr. M.D., F.A.C.S., F.A.C.E.

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  1. Andrew M. Hinson M.D.
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  2. Brendan C. Stack Jr. M.D., F.A.C.S., F.A.C.E.
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Correspondence to Andrew M. Hinson M.D. .

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Editors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    Brendan C. Stack, Jr.

  2. Department of Geniatrics and Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    Donald L. Bodenner

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Hinson, A.M., Stack, B.C. (2017). Parathyroid Physiology and Molecular Biology. In: Stack, Jr., B., Bodenner, D. (eds) Medical and Surgical Treatment of Parathyroid Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-26794-4_4

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  • DOI: https://doi.org/10.1007/978-3-319-26794-4_4

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