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Brachytherapy of the Skin: Cancers and Other Diseases

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Brachytherapy

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Skin…We tan it, we burn it, we pierce it, we ink it, and we moisturize it. When it is wet, we try to dry it, we shave it, and we inject it, and all these things are done in an effort to enhance the appearance of it. Brachytherapy has been used in the management of skin cancer since the first days of therapeutic intervention shortly after the discovery of radium. We present this chapter as a complete reference not only in the standard of care, but to highlight novel applications of the science.

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References

  1. Tay SS, Roediger B, Tong PL et al (2013) The skin-resident immune network. Curr Dermatol Rep 28(3):13–22

    Google Scholar 

  2. Madison KC (2003) Barrier function of the skin: “la raison d’être” of the epidermis. J Invest Dermatol 121(2):231–41

    Article  CAS  PubMed  Google Scholar 

  3. McGrath JA, Eady RA, Pope FM (2004) Rook’s textbook of dermatology, 7th ed, vol 3. Blackwell Publishing, Hoboken NJ, pp 1–3

    Google Scholar 

  4. Orphanidou C, McCargar L, Birmingham C et al (1994) Accuracy of subcutaneous fat measurement: comparison of skinfold calipers, ultrasound, and computed tomography. J Am Diet Assoc 94(8):855–858

    Article  CAS  PubMed  Google Scholar 

  5. Lomas A, Leonardi-Bee J, Bath-Hextall F (2004) A systematic review of worldwide incidence of non-melanoma skin cancer. Br J Dermatol 166:1069–1080

    Article  Google Scholar 

  6. Staples Margaret P, Mark E, Burton Robert C (2006) Non-melanoma skin cancer in Australia: the 2002 national survey and trends since 1985. Med J 184(1):6–10

    CAS  Google Scholar 

  7. Sanat K (2012) Malignant neoplasms following radiotherapy. Int J Environ Res Public Health 9:4744–4759

    Article  Google Scholar 

  8. Berrington de Gonzalez A, Curtis RE, Kry SF et al (2011) Proportion of second cancers attributable to radiotherapy treatment in adults: a cohort study in the US SEER cancer registries. Lancet Oncol 12(4):353–60

    Article  PubMed  Google Scholar 

  9. Salavoura K, Aggeliki K, Tsangaris G et al (2008) Development of cancer in patients with primary immunodeficiencies. Anticancer Res 28:1263–1270

    PubMed  Google Scholar 

  10. Safai B, Diaz B, Schwartz J (1992) Malignant neoplasms associated with human immunodeficiency virus infection. CA Cancer J Clin 42(2):74–95

    Article  CAS  PubMed  Google Scholar 

  11. Zwald FO, Brown M (2011) Skin cancer in solid organ transplant recipients: advances in therapy and management: part I. Epidemiology of skin cancer in solid organ transplant recipients. J Am Acad Dermatol 65(2):253–61

    Article  PubMed  Google Scholar 

  12. Wallingford SC, Olsen CM, Plasmeijer E et al (2011) Skin cancer arising in scars: a systematic. Review Dermatol Surg 37(9):1239–1244

    Article  CAS  PubMed  Google Scholar 

  13. Nikolaou V, Stratigos AJ, Tsao H (2012) Hereditary nonmelanoma skin cancer. Semin Cutan Med Surg 31(4):204–10

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. McCusker M, Basset-Seguin N, Dummer R et al (2014) Metastatic basal cell carcinoma: prognosis dependent on anatomic site and spread of disease. Eur J Cancer 50(4):774–83

    Article  PubMed  Google Scholar 

  15. Cancer Facts & Figures (2014) Estimated numbers of new cancer cases for 2014, excluding basal cell and squamous cell skin cancers and in situ carcinomas except urinary bladder. American Cancer Society. http://www.cancer.org/acs/groups/content/@research/documents/document/acspc-041780.pdf

  16. Cantisani C, De Gado F, Ulrich M et al (2013) Actinic keratosis: review of the literature and new patents. Recent Pat Inflamm Allerg Drug Discov 7(2):168–75

    Article  CAS  Google Scholar 

  17. Dufresne R, Curlin A (1997) Actinic cheilitis. A treatment review. Dermatol Surg 23(1):15–21

    Article  PubMed  Google Scholar 

  18. Neubert T, Lehmann P (2008) Bowen’s disease – a review of newer treatment options. Ther Clin Risk Manag 4(5):1085–1095

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Lin C, Tripcomy L, Keller J et al (2012) Perineural infiltration of cutaneous squamous cell carcinoma and basal cell carcinoma without clinical features. Int J Radiat Oncol Biol Phys 82(1):334–40

    Article  PubMed  Google Scholar 

  20. Panizza B, Solares CA, Redmond M et al (2012) Surgical resection for clinical perineural invasion from cutaneous squamous cell carcinoma of the head and neck. Head Neck 34(11):1622–7

    Article  PubMed  Google Scholar 

  21. Silva JJ, Tsang RW, Panzarella T et al (2000) Results of radiotherapy for epithelial skin cancer of the pinna: the Princess Margaret Hospital experience, 1982–1993. Int J Radiat Oncol Biol Phys 47(2):451–9

    Article  CAS  PubMed  Google Scholar 

  22. Petrovich Z, Kuisk H, Langholz B et al (1987) Treatment results and patterns of failure in 646 patients with carcinoma of the eyelids, pinna, and nose. Am J Surg 154(4):447–50

    Article  CAS  PubMed  Google Scholar 

  23. Wilder RB, Kettelson JM, Shimm DS (1991) Basal cell carcinoma treated with radiation therapy. Cancer 68(10):2134–7

    Article  CAS  PubMed  Google Scholar 

  24. Fitzpatrick PJ (1984) Skin cancer of the head-treatment by radiotherapy. J Otolaryngol 13(4):261–6

    CAS  PubMed  Google Scholar 

  25. Abbatucci JS, Boulier N, Laforge T et al (1989) Radiation therapy of skin carcinomas: results of a hypofractionated irradiation schedule in 675 cases followed more than 2 years. Radiother Oncol 14:113–19

    Article  CAS  PubMed  Google Scholar 

  26. Schlienger P, Brunin F, Desjardins L et al (1996) External radiotherapy for carcinoma of the eyelid: report of 850 cases treated. Int J Radiat Oncol Biol Phys 34:277–87

    Article  CAS  PubMed  Google Scholar 

  27. Locke J, Karimpour S, Young G et al (2001) Radiotherapy for epithelial skin cancer. Int J Radiat Oncol Biol Phys 51:748–55

    Article  CAS  PubMed  Google Scholar 

  28. Guix B, Finestres F, Tello JI et al (2000) Treatment of skin carcinomas of the face by high-dose-rate brachytherapy and custom-made surfaces mold. Int J Radiat Oncol Biol Phys 47:95–102

    Article  CAS  PubMed  Google Scholar 

  29. Crook JM, Mazeron JJ, Marinello G et al (1990) Interstitial Iridium 192 for cutaneous carcinoma of the external nose. Int J Radiat Oncol Biol Phys 18:243–48

    Article  CAS  PubMed  Google Scholar 

  30. Mazeron JJ, Chassagne D, Crook J et al (1988) Radiation therapy of carcinomas of the skin of nose and nasal vestibule: a report of 1676 cases by the Groupe Europeen de Curiethèrapie. Radiother Oncol 13:165–73

    Article  CAS  PubMed  Google Scholar 

  31. Gauden R, Pracy M, Avery AM et al (2013) HDR brachytherapy for superficial non-melanoma skin cancers. J Med Imaging Radiat Oncol 57(2):212–7

    Article  PubMed  Google Scholar 

  32. Bhatnagar A (2013) Non-melanoma skin cancer treated with electronic brachytherapy: results at 1 year. Brachytherapy 12(2):134–40

    Article  PubMed  Google Scholar 

  33. Krengli M, Masini L, Comoli AM et al (2014) Interstitial brachytherapy for eyelid carcinoma: outcome analysis in 60 patients. Strahlenther Onkol 190(3):245–249

    Article  CAS  PubMed  Google Scholar 

  34. Rio E, Bardet E, Ferron C et al (2005) Interstitial brachytherapy of periorificial skin carcinomas of the face: a retrospective study of 97 cases. Int J Radiat Oncol Biol Phys 63(3):753–7

    Article  PubMed  Google Scholar 

  35. Ducassou A, David I, Filleron T et al (2011) Retrospective analysis of local control and cosmetic outcome of 147 periorificial carcinomas of the treated with low-dose rate interstitial brachytherapy. Int J Radiat Oncol Biol Phys 81(3):726–31

    Article  PubMed  Google Scholar 

  36. Hobbs C, Harper J (2011) The use of high dose rate brachytherapy palliation after failed palliative external beam radiotherapy for a cutaneous malignant melanoma of the foot: a case report. J Palliat Med 14(4):521–3

    Article  PubMed  Google Scholar 

  37. Scepanovic D, Paluga M, Rybnikarova M et al (2013) Brachytherapy as a treatment for malignant melanoma of the nasal cavity and nasopharynx; case report. J Contemp Brachytherapy 5(3):157–63

    Article  PubMed  PubMed Central  Google Scholar 

  38. Shi F, Zhang X, Wu K et al (2014) Metastatic malignant melanoma: computed tomography-guided 125l seed implantation treatment. Melanoma Res 24(2):137–43

    Article  CAS  PubMed  Google Scholar 

  39. Chaudhuri A, De-Groot C, Seel M et al (2011) Treatment of regional cutaneous nodular metastases from melanoma using high-dose rate mould brachytherapy. J Med Imaging Radiat Oncol 55(2):206–12

    Article  PubMed  Google Scholar 

  40. Smithers FA, Moaveni Z, De Groot C (2011) The role of radiotherapy in the palliation of cutaneous melanoma metastases: a case series of 3 patients. J Plast Reconstr Aesthet Surg 64(4):550–3

    Article  CAS  PubMed  Google Scholar 

  41. Garibyan L, Cotte SE, Hansen JL et al (2013) Palliative treatment for in-transit cutaneous metastases of Merkel cell carcinoma using surface-mold computer-optimized high-dose-rate brachytherapy. Cancer J 19(4):283–7

    Article  PubMed  PubMed Central  Google Scholar 

  42. Kasper ME, Richter S, Warren N et al (2013) Complete response of endemic Kaposi sarcoma lesions with high-dose-rate brachytherapy: treatment method, results, and toxicity using skin surface applicators. Brachytherapy 12(5):495–9

    Article  PubMed  Google Scholar 

  43. DeSimone JA, Guenova E, Carter JB et al (2013) Low-dose high-dose-rate brachytherapy in the treatment of facial lesions of cutaneous T-cell lymphoma. J Am Acad Dermatol 69(1):61–5

    Article  PubMed  Google Scholar 

  44. Van Limbergen E, Mazeron JJ Skin cancer. The GEC ESTRO handbook of brachytherapy. http://estro-education.org/publications/Documents/final%20introduction.pdf

  45. Maes A, Van Limbergen E (2001) LDR – brachytherapy for non melanoma skin cancer of the face: local control rate, functional and cosmetic outcomes in 173 patients. Radiother Oncol 60(suppl 1):S16

    Article  Google Scholar 

  46. Berman B, Flores F (1999) Comparison of a gel filled cushion and silicone gel sheeting in the treatment of Hypertrophic scar of keloid scars. Dermatol Surg 25(6):484–6

    Article  CAS  PubMed  Google Scholar 

  47. Albert JLM (1817) Quelques resherches surla cheloide. Mem Soc Med d’Emul 744–752

    Google Scholar 

  48. Abergel RP, Pizzurro D, Meeker CA et al (1985) Biochemical composition of the connective tissue in keloids and analysis of collagen metabolism in keloid fibroblast cultures. J Invest Dermatol 84(5):384–90

    Article  CAS  PubMed  Google Scholar 

  49. Chen W, Fu X, Sun X et al (2003) Analysis of differentially expressed genes in keloids and normal skin with cDNA microarray. J Surg Res 113(2):208–16

    Article  CAS  PubMed  Google Scholar 

  50. Dong Z, Mao S, Wen H (2013) Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review). Biomed Rep 1(6):833–836

    CAS  PubMed  PubMed Central  Google Scholar 

  51. Alhady SM, Sivanantharajah K (1969) Keloids in various races. A review of 175 cases. Plast Reconstr Surg 44(6):564–6

    Article  CAS  PubMed  Google Scholar 

  52. Marneros AG, Norris JE, Watanabe S et al (2004) Genome scans provide evidence for keloid susceptibility loci on chromosomes 2q23 and 7p11. J Invest Dermatol 122(5):1126–32

    Article  CAS  PubMed  Google Scholar 

  53. Wang QG, Li XM, Zhang M et al (2014) Effect of two dose fra Chapters 11, 12, 27 and 30 ctionations on postoperative radiotherapy of keloid: an analysis of 107 patients. Beijing Da Xue Xue Bao 46(1):169–72

    Google Scholar 

  54. Wu XL, Gao Z, Song N et al (2009) Clinical study of auricular keloid treatment with both surgical excision and intralesional injection of low-dose 5-fluorouracil and corticosteroids. Zhonghua Yi Xue Za Zhi 89(16):1102–5

    PubMed  Google Scholar 

  55. Davison SP, Dayan JH, Clemens MW et al (2009) Efficacy of intralesional 5-fluorouracil and triamcinolone in the treatment of keloids. Aesthet Surg J 29(1):40–6

    Article  PubMed  Google Scholar 

  56. Jin R, Huang X, Li H et al (2013) Laser therapy for prevention and treatment of pathologic excessive scars. Plast Reconstr Surg 132(6):1747–58

    Article  CAS  PubMed  Google Scholar 

  57. Litrowski N, Boullie MC, Dehesdin D et al (2014) Treatment of earlobe keloids by surgical excision and cryosurgery. J Eur Acad Dermatol Venereol 28(10):1324–1331

    Google Scholar 

  58. O’Brien L, Jones D (2013) Silicone gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database Syst Rev (9):CD003826

    Google Scholar 

  59. Mamalis AD, Lev-Tov H, Nguyen DH et al (2014) Laser and light-based treatment of Keloids – a review. J Eur Acad Dermatol Venereol 289(6):689–699

    Google Scholar 

  60. Saray Y, Gulec AT (2005) Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: a preliminary study. Int J Dermatol 44(9):777–84

    Article  PubMed  Google Scholar 

  61. Janssen De Limpens AM (1980) The local treatment of hypertrophic scars and keloids with topical retinoic acid. Br J Dermatol 103(3):319–23

    Article  CAS  PubMed  Google Scholar 

  62. Park TH, Seo S, Kim JK et al (2011) Outcomes of surgical excision with pressure therapy using magnets and identification of risk factors for recurrent keloids. Plast Reconstr Surg 128(2):431–9

    Article  CAS  PubMed  Google Scholar 

  63. Ogawa R, Tsuguhiro M, Hiko H et al (2007) Postoperative radiation protocol for keloids and hypertrophic scars statistical analysis of 370 sites followed for over 18 months. Department of Plastic and Reconstructive Surgery and Department of Radiation Oncology, Nippon Medical School, 1-1-5 Sendagi Bunkyo-ku, Tokyo

    Google Scholar 

  64. Wang F, Yang H, Liao H et al (2014) Treatment of auricular keloids with surgery and intralesional injection of compound betamethasone. Zhonghua Zheng Xing Wai Ke Za Zhi 30(1):7–10

    CAS  PubMed  Google Scholar 

  65. Kal HB, Veen RE (2005) Biologically effective doses of postoperative radiotherapy in the prevention of keloids: dose-effect relationship. Strahlenther Onkol Niv 181(11):7017–23

    Google Scholar 

  66. Ogawa R, Huang C, Akaishi S et al (2013) Analysis of surgical treatments for earlobe keloids: analysis of 174 lesions in 145 patients. Plast Reconstr Surg 132(5):818e–825e

    Article  CAS  PubMed  Google Scholar 

  67. Flickinger JC (2011) A radiobiological analysis of multicenter data for postoperative keloid radiotherapy. Int J Radiat Biol Phys 79(4):1164–70

    Article  Google Scholar 

  68. Sclafani A, Gordon L, Chadha M et al (1996) Prevention of earlobe keloid recurrence with postoperative corticosteroid injections versus radiation therapy. Dermatol Surg 22(6):569–574

    Google Scholar 

  69. Kovalic JJ, Perez CA (1989) Radiation therapy following keloidectomy: a 20 year experience. Int J Radiat Oncol Biol Phys 17(1):77–80, Radiation Oncology Center, Mallinckrodt Institute of Radiology, St. Louis, MO

    Article  CAS  PubMed  Google Scholar 

  70. Sakamoto T, Oya N, Shibuya K et al (2009) Dose-response relationship and dose optimization in radiotherapy of postoperative keloids. Radiother Oncol 91(2):271–6

    Article  PubMed  Google Scholar 

  71. Guix B, Henriquez I, Andres A et al (2001) Treatment of keloids by high-dose-rate brachytherapy: a seven – year study. Int J Radiat Oncol Biol Phys 50(1):167–172

    Article  CAS  PubMed  Google Scholar 

  72. Escarmant P, Zimmermann S, Amar A (1992) The treatment of 783 keloid scars by iridium 192 interstitial irradiation after surgical excision. Int J Radiat Oncol Biol Phys 26:245–251

    Article  Google Scholar 

  73. Kuribayahi S, Miyashita T, Ozawa Y et al (2011) Post-keloidectomy irradiation using high-dose-rate superficial brachytherapy. J Radiat Res 52:356–368

    Google Scholar 

  74. Fontanesi J, Griffin A (2008) Brachytherapy in the treatment of resected keloids. Author presentation to the 2008 World Congress of Brachytherapy, Boston

    Google Scholar 

  75. Maalej M, Frikha H, Bouaouina N et al (2000) Intraoperative brachytherapy in the management of keloids: apropos of 114 cases. Cancer Radiother 4(4):274–8

    Article  CAS  PubMed  Google Scholar 

  76. Viani GA, Stefano EJ, Afonso SL et al (2009) Postoperative strontium-90 brachytherapy in the prevention of keloids: results and prognostic factors. Int J Radiat Oncol Biol Phys 73(5):15010–6

    Article  Google Scholar 

  77. De Cicco L, Vischioni B, Vavassori A et al (2014) Postoperative management of keloids: low-dose-rate and High-dose-rate brachytherapy. Brachytherapy 13(5):508–513

    Google Scholar 

  78. Rio E, Bardet E, Peuvrel P et al (2010) Perioperative interstitial brachytherapy for recurrent keloid scars. Cancer Radiother 14(1):65–8

    Article  CAS  PubMed  Google Scholar 

  79. Fortson JK, Rosenthal M, Patel V et al (2012) Atypical presentation of mucoepidermoid carcinoma after radiation therapy for the treatment of keloids. Ear Nose Throat J 91(7):286–8

    PubMed  Google Scholar 

  80. Ogawa R, Yoshitatsu S, Yoshida K et al (2009) Is radiation therapy for keloids acceptable? The risk of radiation-induced carcinogenesis. Am Soc Plastic Surg 124:1196. http://www.plasticsurgery.org/Documents/news-resources/statistics/2009-statistics/2009-US-cosmeticreconstructiveplasticsurgeryminimally-invasive-statistics.pdf

    Google Scholar 

  81. Attanoos RL, Appleton MAC, Douglas-Jones AG (1995) The pathogenesis of hidradenitis suppurativa; a closer look at apocrine and apoeccrine glands. Br J Dermatol 133:254–258

    Article  CAS  PubMed  Google Scholar 

  82. Jemec GB, Heidenheim M, Nielsen NH (1996) The prevalence of hidradenitis suppurativa and its potential precursor lesions. J Am Acad Dermatol 35:191–194

    Article  CAS  PubMed  Google Scholar 

  83. Frohlich D, Baaske D, Glatzel M (2000) Strahlentherapie der Hidradenitis axillaris-heute noch aktuell? Strahlenther Onkol 176:286–289

    CAS  PubMed  Google Scholar 

  84. Krause GP (1994) Die Rontgenbehandlung der Schweiβdrusenabszesse. Strahlentherapie 79:253–256

    Google Scholar 

  85. Trombetta M, Werts ED, Parda D (2010) The role of radiotherapy in the treatment of hidradenitis suppurativa; case report and review of the literature. Dermatol Online J 16(2):16–19

    PubMed  Google Scholar 

  86. Pape R, Golles D (1950) Was leisten Rontgenmikrodosen bei der Hydrosadenitis axillaris? Strahlentherapie 81:565–576

    CAS  PubMed  Google Scholar 

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Acknowledgements

The authors wish to thank Susan King for her assistance in the editing and preparation of this chapter.

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Correspondence to James Fontanesi MD .

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Fontanesi, J., Kopitzki, B., Van Limbergen, E. (2016). Brachytherapy of the Skin: Cancers and Other Diseases. In: Montemaggi, P., Trombetta, M., Brady, L. (eds) Brachytherapy. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/978-3-319-26791-3_22

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