Abstract
The Infection Imaging chapter examines how an understanding of the mathematics of the biodistribution of radiopharmaceuticals facilitates (1) the design of optimal study protocols, (2) image interpretation, and (3) quantitation of important functional parameters. Each commonly performed infection study is examined with an emphasis on how useful biologic information can be extracted and quantitated. Included for each study is a brief discussion of the essential aspects of the radiopharmaceutical and relevant biology that are fundamental to the extraction mechanism.
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White Blood Cell Activation Study
Paik JY, Lee KH, Choe YS, et al. Augmented F-18-FDG uptake in activated monocytes occurs during the priming process and involves tyrosine kinases and protein kinase C. J Nucl Med. 2004;45:124–8.
Sugawara Y, Gutowski TD, Fisher SJ, et al. Uptake of positron emission tomography tracers in experimental bacterial infections: A comparative biodistribution study of radiolabeled FDG, thymidine, L-methionine, Ga-67-citrate, and I-125-HSA. Eur J Nucl Med. 1999;26:333–41.
Ballagher BM, Fowler JS, Gutterson NI, et al. Metabolic trapping as a principle of radiopharmaceutical design: Some factors responsible for the biodistribution of [F-18] 2-deoxy-2-fluoro-D-glucose. J Nucl Med. 1978;19:1154–61.
White Blood Cell Migration Study
Resistance of the body to infection: In: Hall JE, editor. Guyton & Hall textbook of medical physiology, 12th ed. Philadelphia: Saunders; 2011, p. 429.
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Klingensmith, W.C. (2016). Infection Imaging. In: The Mathematics and Biology of the Biodistribution of Radiopharmaceuticals - A Clinical Perspective. Springer, Cham. https://doi.org/10.1007/978-3-319-26704-3_17
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DOI: https://doi.org/10.1007/978-3-319-26704-3_17
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Publisher Name: Springer, Cham
Print ISBN: 978-3-319-26702-9
Online ISBN: 978-3-319-26704-3
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