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Histological Analysis in Graft Disease

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Coronary Graft Failure

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Abstract

Graft disease leads to graft failure. From the clinical point of view, graft failure could be acute, subacute, and chronic. Acute failure is related to thrombosis, and subacute and chronic to neointima development and atherosclerotic degeneration, respectively. Histological studies evaluating vessel wall morphological, functional, and regenerative integrity may, at least to some extent, predict the risk of graft failure. Transplantation of venous segments into the coronary arterial circulation initiates an inevitable process of arterialization with occluding atherosclerotic plaques as a net final result. Plaques in venous grafts differ from atherosclerotic lesions found in the native coronary arteries and these morphological differences have impact on their mechanical properties. More fragile vein graft atherosclerotic lesions are very prone to rupture and subsequent thrombosis and consequently acute coronary syndrome. Up to now, some preventative measures against atherosclerosis development have been proposed and their results in histological studies are presented in this chapter.

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Acknowledgements

We would like to thank Agnieszka Malinska, PhD for preparation of the histological figures.

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Authors and Affiliations

  1. Department of Histology and Embryology, Poznan University of Medical Sciences, Poznan, Poland

    Michał Nowicki MD, PhD

  2. Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland

    Bartłomiej Perek MD, PhD

Authors
  1. Michał Nowicki MD, PhD
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  2. Bartłomiej Perek MD, PhD
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Corresponding author

Correspondence to Bartłomiej Perek MD, PhD .

Editor information

Editors and Affiliations

  1. Cardiology, Army's Center for Cardiovascular Di, Bucharest, Romania

    Ion C. Ţintoiu

  2. Department of Surgery, Chinese University of Hong Kong, Sha Tin, Hong Kong

    Malcolm John Underwood

  3. University Fribourg, Hospital HFR Fribourg, Fribourg, Fribourg, Switzerland

    Stephane Pierre Cook

  4. Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan

    Hironori Kitabata

  5. University Medical Center, Texas Tech Univ. Health Science Center, EL PASO, Texas, USA

    Aamer Abbas

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© 2016 Springer International Publishing Switzerland

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Nowicki, M., Perek, B. (2016). Histological Analysis in Graft Disease. In: Ţintoiu, I., Underwood, M., Cook, S., Kitabata, H., Abbas, A. (eds) Coronary Graft Failure. Springer, Cham. https://doi.org/10.1007/978-3-319-26515-5_21

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  • DOI: https://doi.org/10.1007/978-3-319-26515-5_21

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-26513-1

  • Online ISBN: 978-3-319-26515-5

  • eBook Packages: MedicineMedicine (R0)

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