Abstract
The prevalence of constipation varies widely due to non-reporting or because this information is not captured during visits to hospital or outpatient clinics; however, it has been estimated to be in a range of 0.7 % to 79 % (median 16 %) in the worldwide general population (Mugie et al. Best Pract Res Clin Gastroenterol 25(1):3–18, 2011). Mugie and colleagues state that the difference can be attributed to other factors including socioeconomic, cultural, dietary, and environmental. There have been challenges to the way we practice medicine as a result of healthcare reform occurring in the United States and worldwide. Patients’ involvement in their care, and preventive care, is widely emphasized, as well as conscious use of limited resources. Visits to the emergency department (ED) and hospital admissions for constipation are considered avoidable if recognition of the risk factors and education are initiated proactively (Delgado-Guay et al. J Pain Symptom Manage 49(3):497–504, 2015).
Constipation is a common complaint in the ED. In this chapter, we will evaluate and discuss the factors associated with constipation in cancer patients, together with clinical manifestations, diagnoses, mechanism, and pathophysiology. We will also discuss when constipation constitutes an emergency, its treatment, prevention, and patient education.
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Mugie SM, Benninga MA, DiLorenzo C. Epidemiology of constipation in children and adults: a systematic review. Best Pract Res Clin Gastroenterol. 2011;25(1):3–18.
Delgado-Guay MO, Kim YJ, Shin SH, Chisholm G, Williams J, Allo J, et al. Avoidable and unavoidable visits to the emergency department among patients with advanced cancer receiving outpatient palliative care. J Pain Symptom Manage. 2015;49(3):497–504.
Gu M, Gonzalez C, Todd K. Emergent management of constipation in cancer patients. Emerg Med. 2011;43(11):6–12.
Lembo A, Camilleri M. Chronic constipation. N Engl J Med. 2003;349(14):1360–8.
Chevalier P, Lamotte M, Joseph A, Dubois D, Boeckxstaens G. In-hospital costs associated with chronic constipation in Belgium: a retrospective database study. Neurogastroenterol Motil. 2014;26(3):368–76.
Ansari H, Ansari Z, Hutson JM, Southwell BR. Potentially avoidable hospitalisation for constipation in Victoria, Australia in 2010-11. BMC Gastroenterol. 2014;14:125.
Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology. 2006;130(5):1377–90.
Sharma RK. Vincristine and gastrointestinal transit. Gastroenterology. 1988;95(5):1435–6.
Singhal S, Mehta J, Desikan R, Ayers D, Roberson P, Eddlemon P, et al. Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med. 1999;341(21):1565–71.
Robinson BG, Paz-Ares L, Krebs A, Vasselli J, Haddad R. Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Endocrinol Metab. 2010;95(6):2664–71.
O’Connor O, Masszi T, Savage K. Belinostat, a novel pan-histone deacetylase inhibitor (HDACi), in relapsed or refractory peripheral T-cell lymphoma (R/R PTCL): results from the BELIEF trial. J Clin Oncol. 2013;31(15s):8507.
Clemens KE, Klaschik E. Management of constipation in palliative care patients. Curr Opin Support Palliat Care. 2008;2(1):22–7.
Librach SL, Bouvette M, De Angelis C, Farley J, Oneschuk D, Pereira JL, et al. Consensus recommendations for the management of constipation in patients with advanced, progressive illness. J Pain Symptom Manage. 2010;40(5):761–73.
Neis B, Nguyen D, Arora A, Kane S. The role of diagnostic colonoscopy in constipation: a quality improvement project. Am J Gastroenterol. 2013;108(12):1930.
Clemens KE, Klaschik E. Management of constipation in palliative care patients. Curr Opin Support Palliat Care. 2008;2(1):22–7.
Sharma M, Agrawal A. Case report: Stercoral sigmoid colonic perforation with fecal peritonitis. Indian J Radiol Imaging. 2010;20(2):126–8.
Niv G, Grinberg T, Dickman R, Wasserberg N, Niv Y. Perforation and mortality after cleansing enema for acute constipation are not rare but are preventable. Int J Gen Med. 2013;6:323–8.
Robson P. Metastatic spinal cord compression: a rare but important complication of cancer. Clin Med. 2014;14(5):542–5.
Wallaker K, Fortuna E, Bradin S, Macy M, Hassan M, Stanley R. Milk and molasses enemas: clearing things up. J Emerg Nurs. 2014;40(6):546–51.
Lacy BE, Hussain ZH, Mearin F. Treatment for constipation: new and old pharmacological strategies. Neurogastroenterol Motil. 2014;26(6):749–63.
Wirz S, Nadstawek J, Elsen C, Junker U, Wartenberg HC. Laxative management in ambulatory cancer patients on opioid therapy: a prospective, open-label investigation of polyethylene glycol, sodium picosulphate and lactulose. Eur J Cancer Care (Engl). 2012;21(1):131–40.
Sawh SB, Selvaraj IP, Danga A, Cotton AL, Moss J, Patel PB. Use of methylnaltrexone for the treatment of opioid-induced constipation in critical care patients. Mayo Clin Proc. 2012;87(3):255–9.
Mackey AC, Green L, Greene P, Avigan M. Methylnaltrexone and gastrointestinal perforation. J Pain Symptom Manage. 2010;40(1):e1–3.
Mollaoğlu M, Erdoğan G. Effect on symptom control of structured information given to patients receiving chemotherapy. Eur J Oncol Nurs. 2014;18(1):78–84.
Izumi K. The measures to evaluate constipation: a review article. Gastroenterol Nurs. 2014;37(2):137–46.
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Gonzalez, C.E., Halm, J.K. (2016). Constipation in Cancer Patients. In: Todd, K., Thomas, Jr., C. (eds) Oncologic Emergency Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-26387-8_28
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DOI: https://doi.org/10.1007/978-3-319-26387-8_28
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