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The Kidneys and Ureters

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Clinical Embryology
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Abstract

The kidneys, the ureters and the trigone of the urinary bladder all develop from the intermediate mesoderm. The human embryo develops three embryonic kidney structures during development, the pronephros, mesonephros and metanephros.

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References

  1. Hitchcock R, Burge DM. Renal agenesis: an acquired condition. J Pediatr Surg. 1994;29:454.

    Article  CAS  PubMed  Google Scholar 

  2. Barakat AJ, Drougas JG. Occurrence of congenital abnormalities of kidney and urinary tract in 13,775 autopsies. Urology. 1991;38(4):347–50.

    Article  CAS  PubMed  Google Scholar 

  3. Parikh CR, McCall D, Engelman C, Schrier RW. Congenital renal agenesis: case-control analysis of birth characteristics. Am J Kidney Dis. 2002;39(4):689–94.

    Article  PubMed  Google Scholar 

  4. Westland R, Schreuder MF, Ket JCF, van Wijk JAE. Unilateral renal agenesis: a systematic review on associated anomalies and renal injury. Nephrol Dial Transplant. 2013;28(7):1844–55.

    Article  PubMed  Google Scholar 

  5. McPherson E, Carey J, Kramer A, et al. Dominantly inherited renal adysplasia. Am J Med Genet. 26:8631987.

    Article  CAS  PubMed  Google Scholar 

  6. Ashley DJB, Mostofi FK. Renal agenesis and dysgenesis. J Urol. 1960;83:211.

    Article  CAS  PubMed  Google Scholar 

  7. Longo VJ, Thomson GJ. Congenital solitary kidney. J Urol. 1952;68:63–8.

    Article  CAS  PubMed  Google Scholar 

  8. Chow JS, Benson CB, Lebowitz RL. The clinical significance of an empty renal fossa on prenatal sonography. J Ultrasound Med. 2005;24(8):1049–54.

    Article  PubMed  Google Scholar 

  9. Cascio S, Paran S, Puri P. Associated urological anomalies in children with unilateral renal agenesis. J Urol. 2002;162:2566–8.

    Article  Google Scholar 

  10. Donohue RE, Fauver HE. Unilateral absence of the vas deferens. JAMA. 1989;261:1180.

    Article  CAS  PubMed  Google Scholar 

  11. Heinonen PK. Unicornuate uterus and rudimentary horn. Fertil Steril. 1997;68:224–30.

    Article  CAS  PubMed  Google Scholar 

  12. Heinonen PK. Gestational hypertension and preeclampsia associated with unilateral renal agenesis in women with uterine malformations. Eur J Obstet Gynecol Reprod Biol. 2004;114:39–43.

    Article  PubMed  Google Scholar 

  13. Smith NA, Laufer MR. Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome: management and follow-up. Fertil Steril. 2007;87:918–22.

    Article  PubMed  Google Scholar 

  14. Guerrier D, Mouchel T, Pasquier L, Pellerin I. The Mayer-Rokitansky-Küster-Hauser syndrome (congenital absence of uterus and vagina)—phenotypic manifestations and genetic approaches. J Negat Results Biomed. 2006;5:1.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Psooy K. Sports and the solitary kidney: what parents of a young child with a solitary kidney should know. Can Urol Assoc J. 2009;3:67–8.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Sanna-Cherchi S, Ravani P, Corbani V, et al. Renal outcome in patients with congenital anomalies of the kidney and urinary tract. Kidney Int. 2009;76:528–33.

    Article  PubMed  Google Scholar 

  17. Potter EL. Facial characteristics in infants with bilateral renal agenesis. Am J Obstet Gynecol. 1946;51:885, cited in Chapter 17 The kidney and ureter. Embryology for Surgeons. Williams and Wilkins. Ed. Skandalis and Gray 2nd Edition 594-670.

    Article  CAS  PubMed  Google Scholar 

  18. Roodhooft AM, Birnholz JC, Holmes LD. Familial nature of congenital absence and severe dysgenesis of both kidneys. N Engl J Med. 1984;310:1341.

    Article  CAS  PubMed  Google Scholar 

  19. McPherson E. Renal anomalies in families of individuals with congenital solitary kidney. Genet Med. 2007;9(5):298–302.

    Article  PubMed  Google Scholar 

  20. N’Guessan G, Stephens FD. Supernumerary kidney. J Urol. 1983;130:–649.

    Article  Google Scholar 

  21. Oto A, Kerimoglu U, Eskicorapci C, et al. Bilateral supernumerary kidney: imaging findings. JBR-BTR. 2002;85(6):300–3.

    CAS  PubMed  Google Scholar 

  22. Geisinger JF. Supernumerary kidney. J Urol. 1937;38:331, cited in Chapter 17 The kidney and ureter. Embryology for Surgeons. Williams and Wilkins. Ed. Skandalis and Gray 2nd Edition 594-670.

    Article  Google Scholar 

  23. Grieshammer U, Le M, Plump AS, et al. SLIT2 mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell. 2004;6:709–17.

    Article  CAS  PubMed  Google Scholar 

  24. Mustafa M, et al. Bilateral supernumerary kidneys in conjunction with horseshoe anomaly. Saudi J Kidney Dis Transpl. 2012;23(6):1243.

    PubMed  Google Scholar 

  25. Upsdell SM. Supernumerary kidney. Br J Urol. 1989;64(6):650.

    Article  CAS  PubMed  Google Scholar 

  26. Carlson HE. Supernumerary kidney: a summary of fifty-one reported cases. J Urol. 1950;64:221, cited in Chapter 17 The kidney and ureter. Embryology for Surgeons. Williams and Wilkins. Ed. Skandalis and Gray 2nd Edition 594-670.

    Google Scholar 

  27. Gleason PE, Kelalis PP, Husmann DA, Kramer SA. Hydronephrosis in renal ectopia: incidence, etiology and significance. J Urol. 1994;151:1660.

    Article  CAS  PubMed  Google Scholar 

  28. Guarino N, Tadini B, Camardi P, et al. The incidence of associated urological abnormalities in children with renal ectopic. J Urol. 2004;172(4 Pt. 2):1757–9.

    Article  PubMed  Google Scholar 

  29. Warne SA, Wilcox DT, Ledermann SE, Ransley PG. Renal outcome in patients with cloaca. J Urol. 2002;167(6):2548–51; discussion 2551

    Article  CAS  PubMed  Google Scholar 

  30. Thompson DP, Lynn HB. Genital anomalies associated with solitary kidney. Mayo Clin Proc. 1966;41(8):538–48, cited in Chapter 17 The kidney and ureter. Embryology for Surgeons. Williams and Wilkins. Ed. Skandalis and Gray 2nd Edition 594-670.

    CAS  PubMed  Google Scholar 

  31. Downs RA, Lane LW, Burns E. Solitary pelvic kidney: its clinical implications. Urology. 1973;1:51.

    Article  CAS  PubMed  Google Scholar 

  32. Benchekroun A, Kasmaoui EH, Jira H, et al. Pathological pelvic kidney. Ann Urol. 2002;36:231–5.

    Article  CAS  Google Scholar 

  33. Van den Bosch CMA, van Wijk JAE, Beckers GMA, van der Horst HJR, Schreuder MF, Bökenkamp A. Urological and Nephrological findings of renal Ectopia. J Urol. 2010;183(4):1574–8.

    Article  PubMed  Google Scholar 

  34. Weizer AZ, Silverstein AD, Auge BK, Delvecchio FC, Raj G, Albala DM, et al. Determining the incidence of horseshoe kidney from radiographic data at a single institution. J Urol. 2003;170(5):1722–6.

    Article  PubMed  Google Scholar 

  35. Scott JES. Fetal, perinatal, and infant death with congenital renal anomaly. Arch Dis Child. 2002;87(2):114–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Boyden EA. Description of a horseshoe kidney associated with left inferior vena cava and disc-shaped suprarenal glands, together with a note on the occurrence of horseshoe kidneys in human embryos. Anat Rec. 1931;51:187, cited in Chapter 17 The kidney and ureter. Embryology for Surgeons. Williams and Wilkins. Ed. Skandalis and Gray 2nd Edition 594-670

    Article  Google Scholar 

  37. Tripathi I, Guo Q, Wang Y, et al. Midline signaling regulates kidney positioning but not nephrogenesis through Shh. Dev Biol. 2010;340:518–27.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Whitaker RH, Hunt GM. Incidence and distribution of renal anomalies in patients with neural tube defects. Eur Urol. 1987;13(5):322–3.

    Article  CAS  PubMed  Google Scholar 

  39. Cascio S, Sweeney B, Granata C, Piaggio G, Jasonni V, Puri P. Vesicoureteral reflux and ureteropelvic junction obstruction in children with horseshoe kidney: treatment and outcome. J Urol. 2002;167(6):2566–8.

    Article  CAS  PubMed  Google Scholar 

  40. Segura JW, Kelalis PP, Burke EC. Horseshoe kidney in children. J Urol. 1972;108(2):333–6.

    Article  CAS  PubMed  Google Scholar 

  41. Pitts WR, Muecke EC. Horseshoe kidneys: a 40-year experience. J Urol. 1975;113(6):743–6.

    Article  PubMed  Google Scholar 

  42. Wilson C, Azmy AF. Horseshoe kidney in children. Br J Urol. 1986;58:361.

    Article  CAS  PubMed  Google Scholar 

  43. Glenn JF. Analysis of 51 patients with horseshoe kidneys. N Engl J Med. 1959;261:684–7, cited in Chapter 17 The kidney and ureter. Embryology for Surgeons. Williams and Wilkins. Ed. Skandalis and Gray 2nd Edition 594-670

    Article  CAS  PubMed  Google Scholar 

  44. Küpeli B, Isen K, Biri H, Sinik Z, Alkibay T, Karaoğlan U, et al. Extracorporeal shockwave lithotripsy in anomalous kidneys. J Endourol. 1999;13(5):349–52.

    Article  PubMed  Google Scholar 

  45. Raj GV, Auge BK, Weizer AZ, et al. Percutaneous management of calculi within horseshoe kidneys. J Urol. 2003;170:48–51.

    Article  PubMed  Google Scholar 

  46. Mesrobian HG, Kelalis PP, Hrabovsky E, Othersen HB, deLorimier A, Nesmith B. Wilms tumor in horseshoe kidneys: a report from the national Wilms tumor study. J Urol. 1985;133(6):1002–3.

    Article  CAS  PubMed  Google Scholar 

  47. Neville H, Ritchey ML, Shamberger RC, Haase G, Perlman S, Yoshioka T. The occurrence of Wilms tumor in horseshoe kidneys: a report from the National Wilms Tumor Study Group (NWTSG). J Pediatr Surg. 2002;37(8):1134–7.

    Article  PubMed  Google Scholar 

  48. Mallik M, Watson AR. Antenatally detected urinary tract abnormalities: more detection but less action. Pediatr Nephrol. 2008;23(6):897–904.

    Article  PubMed  Google Scholar 

  49. Schreuder MF, Westland R, van Wijk JAE. Unilateral multicystic dysplastic kidney: a meta-analysis of observational studies on the incidence, associated urinary tract malformations and the contralateral kidney. Nephrol Dial Transplant. 2009;24(6):1810–8.

    Article  PubMed  Google Scholar 

  50. Beck AD. The effect of intra-uterine urinary obstruction upon the development of the fetal kidney. J Urol. 1971;105(6):784–9.

    Article  CAS  PubMed  Google Scholar 

  51. Mackie GG, Stephens FD. Duplex kidneys: a correlation of renal dysplasia with position of the ureteral orifice. J Urol. 1975;114:274.

    Article  CAS  PubMed  Google Scholar 

  52. Watanabe T, Yamazaki A, Kurabayashi T, Hanaoka J. Familial multicystic dysplastic kidney. Pediatr Nephrol. 2005;20(8):1200.

    Article  PubMed  Google Scholar 

  53. Petrikovsky BM, Lipson SM, Kaplan MH. Viral studies on amniotic fluid from fetuses with and without abnormalities detected by prenatal sonography. J Reprod Med. 2003;48(4):230–2.

    PubMed  Google Scholar 

  54. Carta M, Cimador M, Giuffrè M, Sergio M, Di Pace MR, De Grazia E, et al. Unilateral multicystic dysplastic kidney in infants exposed to antiepileptic drugs during pregnancy. Pediatr Nephrol. 2007;22(7):1054–7.

    Article  PubMed  Google Scholar 

  55. Miller DC, Rumohr JA, Dunn RL, Bloom DA, Park JM. What is the fate of the refluxing contralateral kidney in children with multicystic dysplastic kidney? J Urol. 2004;172(4 Pt 2):1630–4.

    Article  PubMed  Google Scholar 

  56. Cambio AJ, Evans CP, Kurzrock EA. Non-surgical management of multicystic dysplastic kidney. BJU Int. 2008;101(7):804–8.

    Article  PubMed  Google Scholar 

  57. Narchi H. Risk of Wilms’ tumour with multicystic kidney disease: a systematic review. Arch Dis Child. 2005;90(2):147–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Wacksman J, Phipps L. Report of the multicystic kidney registry: preliminary findings. J Urol. 1993;150(6):1870–2.

    Article  CAS  PubMed  Google Scholar 

  59. Husmann DA. Renal dysplasia: the risks and consequences of leaving dysplastic tissue in situ. Urology. 1998;52(4):533–6.

    Article  CAS  PubMed  Google Scholar 

  60. Seeman T, John U, Bláhová K, Vondrichová H, Janda J, Misselwitz J. Ambulatory blood pressure monitoring in children with unilateral multicystic dysplastic kidney. Eur J Pediatr. 2001;160(2):78–83.

    Article  CAS  PubMed  Google Scholar 

  61. Beckwith JB. The John Lattimer lecture. Wilms tumor and other renal tumors of childhood: an update. J Urol. 1986;136(1 Pt 2):320–4.

    Article  CAS  PubMed  Google Scholar 

  62. Noe HN, Marshall JH, Edwards OP. Nodular renal blastema in the multicystic kidney. J Urol. 1989;142(2 Pt 2):486–8, discussion 489

    Article  CAS  PubMed  Google Scholar 

  63. Siomou E, Papadopoulou F, Kollios KD, Photopoulos A, Evagelidou E, Androulakakis P, et al. Duplex collecting system diagnosed during the first 6 years of life after a first urinary tract infection: a study of 63 children. J Urol. 2006;175(2):678–81, discussion 681–2

    Article  PubMed  Google Scholar 

  64. Atwell JD, Cook PL, Howell CJ, Hyde I, Parker BC. Familial incidence of bifid and double ureters. Arch Dis Child. 1974;49(5):390–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Chwalle R. The process of formation of cystic dilatations of the vesical end of the ureter and of diverticula at the ureteral ostium. Urol Cutan Rev. 1927;31:499, cited in Chapter 17 The kidney and ureter. Embryology for Surgeons. Williams and Wilkins. Ed. Skandalis and Gray 2nd Edition 594-670

    Google Scholar 

  66. Tanagho EA. Embryologic basis for lower ureteral anomalies: a hypothesis. Urology. 1976;7:451–64.

    Article  CAS  PubMed  Google Scholar 

  67. Afshar K, Papanikolaou F, Malek R, Bagli D, Pippi-Salle JL, Khoury A. Vesicoureteral reflux and complete ureteral duplication. Conservative or surgical management? J Urol. 2005;173(5):1725–7.

    Article  PubMed  Google Scholar 

  68. Elder JS, Diaz M, Caldamone AA, Cendron M, Greenfield S, Hurwitz R, et al. Endoscopic therapy for vesicoureteral reflux: a meta-analysis. I. Reflux resolution and urinary tract infection. J Urol. 2006;175(2):716–22.

    Article  PubMed  Google Scholar 

  69. Dhillon HK. Prenatally diagnosed hydronephrosis: the great Ormond street experience. Br J Urol. 1998;81(2):39–44.

    Article  PubMed  Google Scholar 

  70. Thomas DF. Fetal uropathy. Br J Urol. 1990;66(3):225–31.

    Article  CAS  PubMed  Google Scholar 

  71. Alcaraz A, Vinaixa F, Tejedo-Mateu A, Forés MM, Gotzens V, Mestres CA, et al. Obstruction and recanalization of the ureter during embryonic development. J Urol. 1991;145(2):410–6.

    Article  CAS  PubMed  Google Scholar 

  72. Smith ED. Report of Working Party to establish the international nomenclature for the large ureter. In: Bergsma D, Duckett JW, eds. Birth defects. Original articles series. 13th edn. 1977 p. 3–8.

    Google Scholar 

  73. King LR. Megaloureter: definition, diagnosis and management. J Urol. 1980;123(2):222–3.

    Article  CAS  PubMed  Google Scholar 

  74. Incidence megeureter.

    Google Scholar 

  75. Pirker ME, Rolle U, Shinkai T, Shinkai M, Puri P. Prenatal and postnatal neuromuscular development of the ureterovesical junction. J Urol. 2007;177(4):1546–51.

    Article  PubMed  Google Scholar 

  76. Matsuno T, Tokunaka S, Koyanagi T. Muscular development in the urinary tract. J Urol. 1984;132(1):148–52.

    Article  CAS  PubMed  Google Scholar 

  77. Tanagho EA. Intrauterine fetal ureteral obstruction. J Urol. 1973;109(2):196–203.

    Article  CAS  PubMed  Google Scholar 

  78. Dixon JS, Jen PY, Yeung CK, et al. The structure and autonomic innervation of the vesico-ureteric junction in cases of primary ureteric reflux. Br J Urol. 1998;81(1):146–51.

    Article  CAS  PubMed  Google Scholar 

  79. Lee BR, Silver RI, Partin AW, Epstein JI, Gearhart JP. A quantitative histologic analysis of collagen subtypes: the primary obstructed and refluxing megaureter of childhood. Urology. 1998;51(5):820–3.

    Article  CAS  PubMed  Google Scholar 

  80. Hertle L, Nawrath H. In vitro studies on human primary obstructed megaureters. J Urol. 1985;133(5):884–7.

    Article  CAS  PubMed  Google Scholar 

  81. Payabvash S, Kajbafzadeh AM, Tavangar SM, Monajemzadeh M, Sadeghi Z. Myocyte apoptosis in primary obstructive megaureters: the role of decreased vascular and neural supply. J Urol. 2007;178(1):259–64.

    Article  PubMed  Google Scholar 

  82. Vermooten V. A new etiology for certain types of the dilated ureters in children. J Urol. 1939;41:455–63, cited in Chapter 17 The kidney and ureter. Embryology for Surgeons. Williams and Wilkins. Ed. Skandalis and Gray 2nd Edition 594-670

    Article  Google Scholar 

  83. Liu HY, Dhillon HK, Yeung CK, Diamond DA, Duffy PG, Ransley PG. Clinical outcome and management of prenatally diagnosed primary megaureters. J Urol. 1994;152(2

    Article  CAS  Google Scholar 

  84. Nguyen HT, Herndon CDA, Cooper C, Gatti J, Kirsch A, Kokorowski P, et al. The Society for Fetal Urology consensus statement on the evaluation and management of antenatal hydronephrosis. J Pediatr Urol. 2010;6(3):212–31.

    Article  PubMed  Google Scholar 

  85. Song SH, Lee SB, Park YS, Kim KS. Is antibiotic prophylaxis necessary in infants with obstructive hydronephrosis? J Urol. 2007;177(3):1098–101.

    Article  PubMed  Google Scholar 

  86. Gimpel C, Masioniene L, Djakovic N, Schenk J-P, Haberkorn U, Tönshoff B, et al. Complications and long-term outcome of primary obstructive megaureter in childhood. Pediatr Nephrol. 2010;25(9):1679–86.

    Article  PubMed  Google Scholar 

  87. Farrugia M-K, Hitchcock R, Radford A, Burki T, Robb A, Murphy F. British Association of Paediatric Urologists consensus statement on the management of the primary obstructive megaureter. J Pediatr Urol. 2014;10(1):26–33.

    Article  PubMed  Google Scholar 

  88. Shukla AR, Cooper J, Patel RP, et al. Prenatally detected primary megaureter: a role for extended followup. J Urol. 2005;173(4):1353–6.

    Article  PubMed  Google Scholar 

  89. Hemal AK, Ansari MS, Doddamani D, Gupta NP. Symptomatic and complicated adult and adolescent primary obstructive megaureter--indications for surgery: analysis, outcome, and follow-up. Urology. 2003;61(4):703–7.

    Article  CAS  PubMed  Google Scholar 

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Lee, B., Flett, M. (2019). The Kidneys and Ureters. In: Carachi, R., Doss, S. (eds) Clinical Embryology. Springer, Cham. https://doi.org/10.1007/978-3-319-26158-4_42

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