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Radioguided Surgery pp 371–418Cite as

Radioimmunoguided Surgery: Intraoperative Radioimmunodetection for the Radioguided Localization and Resection of Tumors

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Abstract

Radioimmunoguided surgery is a specific application of radioguided surgery which involves intraoperative radioimmunodetection, using a handheld radiation detection device within the operating room in a real-time fashion, for the identification of a radiolabeled antibody or antibody fragment/derivative that has been administered to a patient prior to the time of attempted intraoperative detection and for the sole purpose of guiding the successful performance of the surgical procedure. This chapter discusses (1) the history and development of radioimmunoguided surgery, (2) tumor-associated antigens, (3) monoclonal antibodies, (4) clinical applications of radioimmunoguided surgery, and (5) the future clinical relevance of radioimmunoguided surgery in cancer diagnostics and cancer therapeutics (i.e., oncologic theranostics) as a potential powerful form of antigen-directed cancer surgery.

Portions of the contents of this chapter are adapted from the prior Open Access review article:

Povoski et al.: A comprehensive overview of radioguided surgery using gamma detection probe technology. World Journal of Surgical Oncology, 2009, 7:11. doi:10.1186/1477-7819-7-11 (http://www.wjso.com/content/pdf/1477-7819-7-11.pdf); © 2009 Povoski et al.; licensee BioMed Central Ltd.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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References

  1. Povoski SP, Neff RL, Mojzisik CM, O’Malley DM, Hinkle GH, Hall NC, Murrey Jr DA, Knopp MV, Martin Jr EW. A comprehensive overview of radioguided surgery using gamma detection probe technology. World J Surg Oncol. 2009;7:11.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Ghose T, Tai J, Aquino J, Norvell S, MacDonald A. Tumor localization of 131I-labeled antibodies by radionuclide imaging. Radiology. 1975;116:445–8.

    Article  CAS  PubMed  Google Scholar 

  3. Ghose T, Guclu A, Tai J, MacDonald AS, Norvell ST, Aquino J. Antibody as carrier of 131I in cancer diagnosis and treatment. Cancer. 1975;36:1646–57.

    Article  CAS  PubMed  Google Scholar 

  4. Belitsky P, Ghose T, Aquino J, Tai J, MacDonald AS. Radionuclide imaging of metastases from renal-cell carcinoma by 131I-labeled antitumor antibody. Radiology. 1978;126:515–7.

    Article  CAS  PubMed  Google Scholar 

  5. Belitsky P, Ghose T, Aquino J, Norvell ST, Blair AH. Radionuclide imaging of primary renal-cell carcinoma by I-131-labeled antitumor antibody. J Nucl Med. 1978;19:427–30.

    CAS  PubMed  Google Scholar 

  6. Goldenberg DM, DeLand F, Kim E, Bennett S, Primus FJ, van Nagell JR, Jr EN, DeSimone P, Rayburn P. Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning. N Engl J Med. 1978;298:1384–6.

    Article  CAS  PubMed  Google Scholar 

  7. Carey LC. Foreward. In: Martin Jr EW, editor. Radioimmunoguided surgery (RIGS) in the detection and treatment of colorectal cancer. 1st ed. Austin: R.G. Landes Company; 1994. p. xiii–xiv.

    Google Scholar 

  8. Aitken DR, Thurston MO, Hinkle Jr GH, Martin DT, Haagensen Jr DE, Houchens D, Tuttle SE, Martin Jr EW. Portable gamma probe for radioimmune localization of experimental colon tumor xenografts. J Surg Res. 1984;36:480–9.

    Article  CAS  PubMed  Google Scholar 

  9. Aitken DR, Hinkle GH, Thurston MO, Tuttle SE, Martin DT, Olsen J, Haagensen Jr DE, Houchens D, Martin Jr EW. A gamma-detecting probe for radioimmune detection of CEA-producing tumors. Successful experimental use and clinical case report. Dis Colon Rectum. 1984;27:279–82.

    Article  CAS  PubMed  Google Scholar 

  10. Martin DT, Hinkle GH, Tuttle S, Olsen J, Nabi H, Houchens D, Thurston M, Martin Jr EW. Intraoperative radioimmunodetection of colorectal tumors with a hand-held radiation detector. Am J Surg. 1985;150:672–5.

    Article  CAS  PubMed  Google Scholar 

  11. Martin Jr EW, Hinkle G, Mojzisik C, Thurston MO. Radioimmunoguided surgery: a new intraoperative approach to the detection of tumor. Cancer Treat Res. 1990;51:387–411.

    Article  PubMed  Google Scholar 

  12. Martin Jr EW, Tuttle SE, Rousseau M, Mojzisik CM, O’Dwyer PJ, Hinkle GH, Miller EA, Goodwin RA, Oredipe OA, Barth RF, Olsen JO, Houchens D, Jewell SD, Bucci DM, Adams D, Steplewski Z, Thurston MO. Radioimmunoguided surgery: intraoperative use of monoclonal antibody 17-1A in colorectal cancer. Hybridoma. 1986;5 Suppl 1:S97–S108.

    Google Scholar 

  13. Hinkle GH, Laven DL. Radionucleotides. In: Martin Jr EW, editor. Radioimmunoguided surgery (RIGS) in the detection and treatment of colorectal cancer. 1st ed. Austin: R.G. Landes Company; 1994. p. 29–39.

    Google Scholar 

  14. Hinkle G, Houchens D, Miller E, Nines R, Nabi H, Thurston M, Tuttle S, Mojzisik C, Martin EW Jr. Preferential localization of antibody combinations in tumor xenografts in nude mice. In: Rygaard J, Brϋnner N, Graem N, Spang-Thomsen M, editors. Immune-deficient animals in biomedical research. Copenhagen: 5th Int. Workshop on Immune-Deficient Animals; 1987. p. 248–50.

    Google Scholar 

  15. Thurston MO. Development of the gamma-detecting probe for radioimmunoguided surgery. In: Martin EW, editor. Radioimmunoguided surgery (RIGS) in the detection and treatment of colorectal cancer. 1st ed. Austin: R.G. Landes Company; 1994. p. 41–65.

    Google Scholar 

  16. Berens A, Mosic J. The RIGS patient in the clinical setting. In: Martin EW, editor. Radioimmunoguided surgery (RIGS) in the detection and treatment of colorectal cancer. 1st ed. Austin: R.G. Landes Company; 1994. p. 107–23.

    Google Scholar 

  17. Nieroda CA, Milenic DE, Colcher D, Schlom J. Monoclonal antibodies for use in radioimmunoguided surgery (RIGS). In: Martin Jr EW, editor. Radioimmunoguided surgery (RIGS) in the detection and treatment of colorectal cancer. 1st ed. Austin: R.G. Landes Company; 1994. p. 7–27.

    Google Scholar 

  18. Hinkle GH, Houchens DP, Sampsel J, Schneebaum S. The RIGS system using animal models. In: Martin Jr EW, editor. Radioimmunoguided surgery (RIGS) in the detection and treatment of colorectal cancer. 1st ed. Austin: R.G. Landes Company; 1994. p. 67–80.

    Google Scholar 

  19. Sun D, Bloomston M, Hinkle G, Al-Saif OH, Hall NC, Povoski SP, Arnold MW, Martin EW. Radioimmunoguided surgery (RIGS), PET/CT image-guided surgery, and fluorescence image-guided surgery: past, present, and future. J Surg Oncol. 2007;96:297–308.

    Article  CAS  PubMed  Google Scholar 

  20. Leenaars M, Hendriksen CF. Critical steps in the production of polyclonal and monoclonal antibodies: evaluation and recommendations. ILAR J. 2005;46:269–79.

    Article  CAS  PubMed  Google Scholar 

  21. Schwaber J, Cohen EP. Human x mouse somatic cell hybrid clone secreting immunoglobulins of both parental types. Nature. 1973;244(5416):444–7.

    Article  CAS  PubMed  Google Scholar 

  22. Schwaber J, Cohen EP. Pattern of immunoglobulin synthesis and assembly in a human-mouse somatic cell hybrid clone. Proc Natl Acad Sci U S A. 1974;71:2203–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Köhler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975;256:495–7.

    Article  PubMed  Google Scholar 

  24. Schroff RW, Foon KA, Beatty SM, Oldham RK, Morgan Jr AC. Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy. Cancer Res. 1985;45:879–85.

    CAS  PubMed  Google Scholar 

  25. Morrison SL, Johnson MJ, Herzenberg LA, Oi VT. Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains. Proc Natl Acad Sci U S A. 1984;81:387–411.

    Article  Google Scholar 

  26. Riechmann L, Clark M, Waldmann H, Winter G. Reshaping human antibodies for therapy. Nature. 1988;332(6162):323–7.

    Article  CAS  PubMed  Google Scholar 

  27. Tamura M, Milenic DE, Iwahashi M, Padlan E, Schlom J, Kashmiri SVS. Structural correlates of an anticarcinoma antibody: identification of a specificity-determining residues (SDRs) and development of a minimally immunogenic antibody variant by retention of SDRs only. J Immunol. 2000;164:1432–41.

    Article  CAS  PubMed  Google Scholar 

  28. Bruggeman M, Neuberger MS. Strategies for expressing human antibody repertoires in transgenic mice. Immunol Today. 1996;17:391–7.

    Article  Google Scholar 

  29. Mendez MJ, Green LL, Corvalan JR, Jia XC, Maynard-Currie CE, Yang XD, Gallo ML, Louie DM, Lee DV, Erickson KL, Luna J, Roy CM, Abderrahim H, Kirschenbaum F, Noguchi M, Smith DH, Fukushima A, Hales JF, Klapholz S, Finer MH, Davis CG, Zsebo KM, Jakobovits A. Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice. Nat Genet. 1997;15:146–56.

    Article  CAS  PubMed  Google Scholar 

  30. McCafferty J, Griffiths AD, Winter G, Chiswell DJ. Phage antibodies: filamentous phage displaying antibody variable domains. Nature. 1990;348(6301):552–4.

    Article  CAS  PubMed  Google Scholar 

  31. Winter G, Griffiths AD, Hawkins RE, Hoogenboom HR. Making antibodies by phage display technology. Annu Rev Immunol. 1994;12:433–55.

    Article  CAS  PubMed  Google Scholar 

  32. Burton DR, Barbas III CF. Human antibodies from combinatorial libraries. Adv Immunol. 1994;57:191–280.

    Article  CAS  PubMed  Google Scholar 

  33. Martin Jr EW, Barnes JA, Thurston MO. Introduction: the RIGS concept. In: Martin Jr EW, editor. Radioimmunoguided surgery (RIGS) in the detection and treatment of colorectal cancer. 1st ed. Austin: R.G. Landes Company; 1994. p. 1–6.

    Google Scholar 

  34. Martin Jr EW, Thurston MO. The use of monoclonal antibodies (MAbs) and the development of an intraoperative hand-held probe for cancer detection. Cancer Invest. 1996;14:560–71.

    Article  PubMed  Google Scholar 

  35. Martin Jr EW, Thurston MO. Intraoperative radioimmunodetection. Semin Surg Oncol. 1998;15:205–8.

    Article  PubMed  Google Scholar 

  36. Paganelli G, Magnani P, Fazio F. Pretargeting of carcinomas with the avidin-biotin system. Int J Biol Markers. 1993;8:155–9.

    CAS  PubMed  Google Scholar 

  37. Boerman OC, van Schaijk FG, Oyen WJ, Corstens FH. Pretargeted radioimmunotherapy of cancer: progress step by step. J Nucl Med. 2003;44:400–11.

    PubMed  Google Scholar 

  38. Gruaz-Guyon A, Janevik-Ivanovska E, Raguin O, De Labriolle-Vaylet C, Barbet J. Radiolabeled bivalent haptens for tumor immunodetection and radioimmunotherapy. Q J Nucl Med. 2001;45:201–6.

    CAS  PubMed  Google Scholar 

  39. Goldenberg DM, Rossi EA, Sharkey RM, McBride WJ, Chang CH. Multifunctional antibodies by the dock-and-lock method for improved cancer imaging and therapy by pretargeting. J Nucl Med. 2008;49:158–63.

    Article  CAS  PubMed  Google Scholar 

  40. Johnson VG, Schlom J, Paterson AJ, Bennett J, Magnani JL, Colcher D. Analysis of a human tumor-associated glycoprotein (TAG-72) identified by monoclonal antibody B72.3. Cancer Res. 1986;46:850–7.

    CAS  PubMed  Google Scholar 

  41. Sheer DG, Schlom J, Cooper HL. Purification and composition of the human tumor-associated glycoprotein (TAG-72) defined by monoclonal antibodies CC49 and B72.3. Cancer Res. 1988;48:6811–8.

    CAS  PubMed  Google Scholar 

  42. Loy TS, Nashelsky MB. Reactivity of B72.3 with adenocarcinomas. An immunohistochemical study of 476 cases. Cancer. 1993;72:2495–8.

    Article  CAS  PubMed  Google Scholar 

  43. Colcher D, Milenic D, Roselli M, Raubitschek A, Yarranton G, King D, Adair J, Whittle N, Bodmer M, Schlom J. Characterization and biodistribution of recombinant and recombinant/chimeric constructs of monoclonal antibody B72.3. Cancer Res. 1989;49:1738–45.

    CAS  PubMed  Google Scholar 

  44. Stramignoni D, Bowen R, Atkinson BF, Schlom J. Differential reactivity of monoclonal antibodies with human colon adenocarcinomas and adenomas. Int J Cancer. 1983;31:543–52.

    Article  CAS  PubMed  Google Scholar 

  45. Ohuchi N, Simpson JF, Colcher D, Schlom J. Complementation of anti-CEA and anti-TAG-72 monoclonal antibodies in reactivity to human gastric adenocarcinomas. Int J Cancer. 1987;40:726–33.

    Article  CAS  PubMed  Google Scholar 

  46. Thor A, Gorstein F, Ohuchi N, Szpak CA, Johnston WW, Schlom J. Tumor-associated glycoprotein (TAG-72) in ovarian carcinomas defined by monoclonal antibody B72.3. J Natl Cancer Inst. 1986;76:995–1006.

    CAS  PubMed  Google Scholar 

  47. Nuti M, Teramoto YA, Mariani-Costantini R, Hand PH, Colcher D, Schlom J. A monoclonal antibody (B72.3) defines patterns of distribution of a novel tumor-associated antigen in human mammary carcinoma cell populations. Int J Cancer. 1982;29:539–45.

    Article  CAS  PubMed  Google Scholar 

  48. Thor A, Ohuchi N, Szpak CA, Johnston WW, Schlom J. Distribution of oncofetal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody B72.3. Cancer Res. 1986;46:3118–24.

    CAS  PubMed  Google Scholar 

  49. Colcher D, Hand PH, Nuti M, Schlom J. A spectrum of monoclonal antibodies reactive with human mammary tumor cells. Proc Natl Acad Sci U S A. 1981;78:3199–203.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Thor A, Viglione MJ, Muraro R, Ohuchi N, Schlom J, Gorstein F. Monoclonal antibody B72.3 reactivity with human endometrium: a study of normal and malignant tissues. Int J Gynecol Pathol. 1987;6:235–47.

    Article  CAS  PubMed  Google Scholar 

  51. Muraro R, Kuroki M, Wunderlich D, Poole DJ, Colcher D, Thor A, Greiner JW, Simpson JF, Molinolo A, Noguchi P, Schlom J. Generation and characterization of B72.3 second generation monoclonal antibodies reactive with the tumor-associated glycoprotein 72 antigen. Cancer Res. 1988;48:4588–96.

    CAS  PubMed  Google Scholar 

  52. Colcher D, Minelli MF, Roselli M, Muraro R, Simpson-Milenic D, Schlom J. Radioimmunolocalization of human carcinoma xenografts with B72.3 second generation monoclonal antibodies. Cancer Res. 1988;48:4597–603.

    CAS  PubMed  Google Scholar 

  53. Schlom J, Eggensperger D, Colcher D, Molinolo A, Houchens D, Miller LS, Hinkle G, Siler K. Therapeutic advantage of high-affinity anticarcinoma radioimmunoconjugates. Cancer Res. 1992;52:1067–72.

    CAS  PubMed  Google Scholar 

  54. Colcher D, Milenic DE, Ferroni P, Carrasquillo JA, Reynolds JC, Roselli M, Larson M, Schlom J. In vivo fate of monoclonal antibody B72.3 in patients with colorectal cancer. J Nucl Med. 1990;3:1133–42.

    Google Scholar 

  55. Mojzisik CM, Cook CH, Schneebaum S. Safety and performance factors in the development and clinical use of the RIGS system. In: Martin Jr EW, editor. Radioimmunoguided surgery (RIGS) in the detection and treatment of colorectal cancer. 1st ed. Austin: R.G. Landes Company; 1994. p. 81–105.

    Google Scholar 

  56. Frödin JE, Lefvert AK, Mellstedt H. The clinical significance of HAMA in patients treated with mouse monoclonal antibodies. Cell Biophys. 1992;21:153–65.

    Article  PubMed  Google Scholar 

  57. Gruber R, van Haarlem LJ, Warnaar SO, Holz E, Riethmüller G. The human antimouse immunoglobulin response and the anti-idiotypic network have no influence on clinical outcome in patients with minimal residual colorectal cancer treated with monoclonal antibody CO17-1A. Cancer Res. 2000;60:1921–6.

    CAS  PubMed  Google Scholar 

  58. Kashmiri SV, Shu L, Padlan EA, Milenic DE, Schlom J, Hand PH. Generation, characterization, and in vivo studies of humanized anticarcinoma antibody CC49. Hybridoma. 1995;14:461–73.

    Article  CAS  PubMed  Google Scholar 

  59. Xiao J, Horst S, Hinkle G, Cao X, Kocak E, Fang J, Young D, Khazaeli M, Agnese D, Sun D, Martin Jr E. Pharmacokinetics and clinical evaluation of 125I-radiolabeled humanized CC49 monoclonal antibody (HuCC49deltaC(H)2) in recurrent and metastatic colorectal cancer patients. Cancer Biother Radiopharm. 2005;20:16–26.

    Article  CAS  PubMed  Google Scholar 

  60. Slavin-Chiorini DC, Kashmiri SV, Lee HS, Milenic DE, Poole DJ, Bernon E, Schlom J, Hand PH. A CDR-grafted (humanized) domain-deleted antitumor antibody. Cancer Biother Radiopharm. 1997;12:305–16.

    Article  CAS  PubMed  Google Scholar 

  61. Fang L, Holford NH, Hinkle G, Cao X, Xiao JJ, Bloomston M, Gibbs S, Saif OH, Dalton JT, Chan KK, Schlom J, Martin Jr EW, Sun D. Population pharmacokinetics of humanized monoclonal antibody HuCC49deltaCH2 and murine antibody CC49 in colorectal cancer patients. J Clin Pharmacol. 2007;47:227–37.

    Article  CAS  PubMed  Google Scholar 

  62. Yoon SO, Lee TS, Kim SJ, Jang MH, Kang YJ, Park JH, Kim KS, Lee HS, Ryu CJ, Gonzales NR, Kashmiri SV, Lim SM, Choi CW, Hong HJ. Construction, affinity maturation, and biological characterization of an anti-tumor-associated glycoprotein-72 humanized antibody. J Biol Chem. 2006;281:6985–92.

    Article  CAS  PubMed  Google Scholar 

  63. Kim SJ, Hong HJ. Guided selection of human antibody light chains against TAG-72 using a phage display chain shuffling approach. J Microbiol. 2007;45:572–7.

    CAS  PubMed  Google Scholar 

  64. Muraro R, Wunderlich D, Thor A, Lundy J, Noguchi P, Cunningham R, Schlom J. Definition by monoclonal antibodies of a repertoire of epitopes on carcinoembryonic antigen differentially expressed in human colon carcinomas versus normal adult tissues. Cancer Res. 1985;45:5769–80.

    CAS  PubMed  Google Scholar 

  65. Hammarström S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol. 1999;9:67–81.

    Article  PubMed  Google Scholar 

  66. Goldenberg DM, Kim EE, DeLand FH, Bennett S, Primus FJ. Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen. Cancer Res. 1980;40:2984–92.

    CAS  PubMed  Google Scholar 

  67. Nap M, Hammarstrom M-L, Borer O, Hammarstrom S, Wagner C, Handt S, Schreyer M, Mach JP, Buchegget F, von Kleist S, Grunert F, Seguin P, Fuks A, Holm R, Lamerz R. Specificity and affinity of monoclonal antibodies against carcinoembryonic antigen. Cancer Res. 1992;52:2329–39.

    CAS  PubMed  Google Scholar 

  68. Shi ZR, Tacha D, Itzkowitz SH. Monoclonal antibody COL-1 reacts with restricted epitopes on carcinoembryonic antigen: an immunohistochemical study. J Histochem Cytochem. 1994;42:1215–9.

    Article  CAS  PubMed  Google Scholar 

  69. Dawson PM, Blair SD, Begent RH, Kelly AM, Boxer GM, Theodorou NA. The value of radioimmunoguided surgery in first and second look laparotomy for colorectal cancer. Dis Colon Rectum. 1991;34:217–22.

    Article  CAS  PubMed  Google Scholar 

  70. Gu J, Zhao J, Li Z, Yang Z, Zhang J, Gao Z, Wang Y, Xu G. Clinical application of radioimmunoguided surgery in colorectal cancer using 125I-labeled carcinoembryonic antigen-specific monoclonal antibody submucosally. Dis Colon Rectum. 2003;46:1659–66.

    Article  PubMed  Google Scholar 

  71. Goldenberg DM, Goldenberg H, Sharkey RM, Lee RE, Horowitz JA, Hall TC, Hansen HJ. In-vivo antibody imaging for the detection of human tumors. Cancer Treat Res. 1990;51:273–92.

    Article  CAS  PubMed  Google Scholar 

  72. Goldenberg DM, Goldenberg H, Sharkey RM, Higginbotham-Ford E, Lee RE, Swayne LC, Burger KA, Tsai D, Horowitz JA, Hall TC, Pinsky CM, Hansen HJ. Clinical studies of cancer radioimmunodetection with carcinoembryonic antigen monoclonal antibody fragments labeled with 123I or 99mTc. Cancer Res. 1990;50:909s–21s.

    Google Scholar 

  73. Göttlinger HG, Funke I, Johnson JP, Gokel JM, Riethmüller G. The epithelial cell surface antigen 17-1A, a target for antibody-mediated tumor therapy: its biochemical nature, tissue distribution and recognition by different monoclonal antibodies. Int J Cancer. 1986;38:47–53.

    Article  PubMed  Google Scholar 

  74. Göttlinger H, Johnson J, Riethmüller G. Biochemical and epitope analysis of the 17-1A membrane antigen. Hybridoma. 1986;5 Suppl 1:S29–S37.

    Google Scholar 

  75. Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO. Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. J Cell Biol. 1994;125:437–46.

    Article  CAS  PubMed  Google Scholar 

  76. Leibovitz A, Stinson JC, McCombs 3rd WB, McCoy CE, Mazur KC, Mabry ND. Classification of human colorectal adenocarcinoma cell lines. Cancer Res. 1976;36:4562–9.

    CAS  PubMed  Google Scholar 

  77. Packeisen J, Kaup-Franzen C, Knieriem HJ. Detection of surface antigen 17-1A in breast and colorectal cancer. Hybridoma. 1999;18:37–40.

    Article  CAS  PubMed  Google Scholar 

  78. Herlyn M, Steplewski Z, Herlyn D, Koprowski H. Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies. Proc Natl Acad Sci U S A. 1979;76:1438–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Herlyn DM, Steplewski Z, Herlyn MF, Koprowski H. Inhibition of growth of colorectal carcinoma in nude mice by monoclonal antibody. Cancer Res. 1980;40:717–21.

    CAS  PubMed  Google Scholar 

  80. Opavský R, Pastoreková S, Zelník V, Gibadulinová A, Stanbridge EJ, Závada J, Kettmann R, Pastorek J. Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships. Genomics. 1996;33:480–7.

    Article  PubMed  Google Scholar 

  81. Leibovich BC, Sheinin Y, Lohse CM, Thompson RH, Cheville JC, Zavada J, Kwon ED. Carbonic anhydrase IX is not an independent predictor of outcome for patients with clear cell renal cell carcinoma. J Clin Oncol. 2007;25:4757–64.

    Article  PubMed  Google Scholar 

  82. Oosterwijk E. Carbonic anhydrase IX: historical and future perspectives. BJU Int. 2008;101 Suppl 4:2–7.

    Article  CAS  PubMed  Google Scholar 

  83. Stillebroer AB, Mulders PF, Boerman OC, Oyen WJ, Oosterwijk E. Carbonic anhydrase IX in renal cell carcinoma: implications for prognosis, diagnosis, and therapy. Eur Urol. 2010;58:75–83.

    Article  CAS  PubMed  Google Scholar 

  84. Povoski SP, Hall NC, Murrey Jr DA, Sharp DS, Hitchcock CL, Mojzisik CM, Bahnson EE, Knopp MV, Martin Jr EW, Bahnson RR. Multimodal imaging and detection strategy with 124 I-labeled chimeric monoclonal antibody cG250 for accurate localization and confirmation of extent of disease during laparoscopic and open surgical resection of clear cell renal cell carcinoma. Surg Innov. 2013;20:59–69.

    Article  PubMed  PubMed Central  Google Scholar 

  85. Oosterwijk E, Ruiter DJ, Hoedemaeker PJ, Pauwels EK, Jonas U, Zwartendijk J, Warnaar SO. Monoclonal antibody G 250 recognizes a determinant present in renal-cell carcinoma and absent from normal kidney. Int J Cancer. 1986;38:489–94.

    Article  CAS  PubMed  Google Scholar 

  86. Liao SY, Aurelio ON, Jan K, Zavada J, Stanbridge EJ. Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney. Cancer Res. 1997;57:2827–31.

    CAS  PubMed  Google Scholar 

  87. Grabmaier K, Vissers JL, De Weijert MC, Oosterwijk-Wakka JC, Van Bokhoven A, Brakenhoff RH, Noessner E, Mulders PA, Merkx G, Figdor CG, Adema GJ, Oosterwijk E. Molecular cloning and immunogenicity of renal cell carcinoma-associated antigen G250. Int J Cancer. 2000;85:865–70.

    Article  CAS  PubMed  Google Scholar 

  88. Bismar TA, Bianco FJ, Zhang H, Li X, Sarkar FH, Sakr WA, Grignon DJ, Che M. Quantification of G250 mRNA expression in renal epithelial neoplasms by real-time reverse transcription-PCR of dissected tissue from paraffin sections. Pathology. 2003;35:513–7.

    Article  CAS  PubMed  Google Scholar 

  89. Oosterwijk E, Bander NH, Divgi CR, Welt S, Wakka JC, Finn RD, Carswell EA, Larson SM, Warnaar SO, Fleuren GJ, Oettgen HF, Old LJ. Antibody localization in human renal cell carcinoma: a phase I study of monoclonal antibody G250. J Clin Oncol. 1993;11:738–50.

    CAS  PubMed  Google Scholar 

  90. Oosterwijk E, Debruyne FM. Radiolabeled monoclonal antibody G250 in renal-cell carcinoma. World J Urol. 1995;13:186–90.

    Article  CAS  PubMed  Google Scholar 

  91. Steffens MG, Boerman OC, Oosterwijk-Wakka JC, Oosterhof GO, Witjes JA, Koenders EB, Oyen WJ, Buijs WC, Debruyne FM, Corstens FH, Oosterwijk E. Targeting of renal cell carcinoma with iodine-131-labeled chimeric monoclonal antibody G250. J Clin Oncol. 1997;15(4):1529–37.

    CAS  PubMed  Google Scholar 

  92. Uemura H, Nakagawa Y, Yoshida K, Saga S, Yoshikawa K, Hirao Y, Oosterwijk E. MN/CA IX/G250 as a potential target for immunotherapy of renal cell carcinomas. Br J Cancer. 1999;81:741–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Divgi CR, Pandit-Taskar N, Jungbluth AA, Reuter VE, Gönen M, Ruan S, Pierre C, Nagel A, Pryma DA, Humm J, Larson SM, Old LJ, Russo P. Preoperative characterisation of clear-cell renal carcinoma using iodine-124-labelled antibody chimeric G250 (124I-cG250) and PET in patients with renal masses: a phase I trial. Lancet Oncol. 2007;8:304–10.

    Article  CAS  PubMed  Google Scholar 

  94. O’Dwyer PJ, Mojzisik CM, Hinkle GH, Tuttle SE, Rousseau M, Olsen J, Tuttle SE, Barth RF, Thurston MO, McCabe DP, Farrar WB, Martin EW Jr. Intraoperative probe-directed immunodetection using a monoclonal antibody. Arch Surg 1986, 121:1391–4.

    Google Scholar 

  95. Petty LR, Mojzisik CM, Hinkle GH, Ignaszewski J, Loesch J, Berens A, Thurston MO, Martin Jr EW. Radioimmunoguided surgery: a phase I/II study using iodine-125 labeled to 17-1A IgG2A in patients with colorectal cancer. Antibody Immunoconjugates Radiopharm. 1991;4:603–11.

    Google Scholar 

  96. Colcher D, Keenan AM, Larson SM, Schlom J. Prolonged binding of a radiolabeled monoclonal antibody (B72.3) used for the in situ radioimmunodetection of human colon carcinoma xenografts. Cancer Res. 1984;44:5744–9.

    CAS  PubMed  Google Scholar 

  97. Sickle-Santanello BJ, O’Dwyer PJ, Mojzisik C, Tuttle SE, Hinkle GH, Rousseau M, Schlom J, Colcher D, Thurston MO, Nieroda C, Sardi A, Farrar WB, Minton JP, Martin Jr EW. Radioimmunoguided surgery using the monoclonal antibody B72.3 in colorectal tumors. Dis Colon Rectum. 1987;30:761–4.

    Article  CAS  PubMed  Google Scholar 

  98. Martin Jr EW, Mojzisik CM, Hinkle GH, Sampsel J, Siddiqi M, Tuttle SE, Sickle-Santanello B, Colcher D, Thurston MO, Bell J, Farrar WB, Schlom J. Radioimmunoguided surgery using monoclonal antibody. Am J Surg. 1988;156:386–92.

    Article  PubMed  Google Scholar 

  99. Tuttle SE, Jewell SD, Mojzisik CM, Hinkle GH, Colcher D, Schlom J, Martin EW. Intraoperative radioimmunolocalization of colorectal carcinoma with a hand-held gamma probe and MAb B72.3: comparison of in vivo gamma probe counts with in vitro MAb radiolocalization. Int J Cancer. 1988;42:352–8.

    Article  CAS  PubMed  Google Scholar 

  100. Nieroda CA, Mojzisik C, Sardi A, Ferrara P, Hinkle G, Thurston MO, Martin Jr EW. Radioimmunoguided surgery in primary colon cancer. Cancer Detect Prev. 1990;14:651–6.

    CAS  PubMed  Google Scholar 

  101. Martin Jr EW, Carey LC. Second-look surgery for colorectal cancer. Ann Surg. 1991;214:321–5; discussion 326–7.

    Article  PubMed  PubMed Central  Google Scholar 

  102. Cohen AM, Martin Jr EW, Lavery I, Daly J, Sardi A, Aitken D, Bland K, Mojzisik C, Hinkle G. Radioimmunoguided surgery using iodine 125 B72.3 in patients with colorectal cancer. Arch Surg. 1991;126:349–52.

    Article  CAS  PubMed  Google Scholar 

  103. Di Carlo V, Stella M, De Nardi P, Baratti D, Sassi I, Mangili F, Zito M, Badellino F, Dionigi R, Fazio F. The role of B72.3 125-I monoclonal antibody in the radioimmunoguided surgery of colorectal neoplasms. Ann Ital Chir. 1991;62:245–9.

    PubMed  Google Scholar 

  104. Stella M, De Nardi P, Paganelli G, Sassi I, Zito M, Magnani P, Baratti D, Mangili F, Spagnolo W, Siccardi AG, Fazio F, Di Carlo V. Surgery for colorectal cancer guided by radiodetecting probe. Clinical evaluation using monoclonal antibody B72.3. Eur J Surg. 1991;157:485–8.

    CAS  PubMed  Google Scholar 

  105. Di Carlo V, Badellino F, Stella M, De Nardi P, Fazio F, Percivale P, Bertoglio S, Schenone F, Benevento A, Carcano G, Dominioni L, Dionigi R. Role of B72.3 iodine 125-labeled monoclonal antibody in colorectal cancer detection by radioimmunoguided surgery. Surgery. 1994;115:190–8.

    PubMed  Google Scholar 

  106. Stella M, De Nardi P, Paganelli G, Magnani P, Mangili F, Sassi I, Baratti D, Gini P, Zito F, Cristallo M, Fazio F, Di Carlo V. Avidin-biotin system in radioimmunoguided surgery for colorectal cancer. Advantages and limits. Dis Colon Rectum. 1994;37:335–43.

    Article  CAS  PubMed  Google Scholar 

  107. Paganelli G, Stella M, Zito F, Magnani P, De Nardi P, Mangili F, Baratti D, Veglia F, Di Carlo V, Siccardi AG, Fazio F. Radioimmunoguided surgery using iodine-125-labeled biotinylated monoclonal antibodies and cold avidin. J Nucl Med. 1994;35:1970–5.

    CAS  PubMed  Google Scholar 

  108. Di Carlo V, Stella M, De Nardi P, Fazio F. Radioimmunoguided surgery: clinical experience with different monoclonal antibodies and methods. Tumori. 1995;81(3 Suppl):98–102.

    PubMed  Google Scholar 

  109. Bertoglio S, Benevento A, Percivale P, Cafiero F, Moresco L, Peressini A, Dionigi R, Badellino F. Radioimmunoguided surgery benefits in carcinoembryonic antigen-directed second-look surgery in the asymptomatic patient after curative resection of colorectal cancer. Semin Surg Oncol. 1998;15:263–7.

    Article  CAS  PubMed  Google Scholar 

  110. Bertoglio S, Percivale P, Schenone F, Peressini A, Murolo C, Badellino F. Role of tumor-associated antigen expression in radioimmunoguided surgery for colorectal and breast cancer. Semin Surg Oncol. 1998;15:249–53.

    Article  CAS  PubMed  Google Scholar 

  111. Percivale P, Bertoglio S, Meszaros P, Schenone F, Gipponi M, Moresco L, Cosso M, Badellino F. Radioimmunoguided surgery with different iodine-125 radiolabeled monoclonal antibodies in recurrent colorectal cancer. Semin Surg Oncol. 1998;15:231–4.

    Article  CAS  PubMed  Google Scholar 

  112. Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W. Radioimmunoguided surgery in colorectal cancer: a 6-year experience with four different technical solutions. Semin Surg Oncol. 1998;15:226–30.

    Article  CAS  PubMed  Google Scholar 

  113. Veroux G, Nicosia A, Veroux P, Cardillo P, Veroux M, Amodeo C. Radioimmunoguided surgery. Hepatogastroenterology. 1999;30:3099–108.

    Google Scholar 

  114. Krag DN, Haseman MK, Ford P, Smith L, Taylor MH, Schneider P, Goodnight JE. Gamma probe location of 111indium-labeled B72.3: an extension of immunoscintigraphy. J Surg Oncol. 1992;51:226–30.

    Article  CAS  PubMed  Google Scholar 

  115. Muxi A, Pons F, Vidal-Sicart S, Setoain FJ, Herranz R, Novell F, Fernandez RM, Trias M, Setoain J. Radioimmunoguided surgery of colorectal carcinoma with an 111In-labelled anti-TAG72 monoclonal antibody. Nucl Med Commun. 1999;20:123–30.

    Article  CAS  PubMed  Google Scholar 

  116. Hladik P, Vizda J, Bedrna J, Simkovic D, Strnad L, Smejkal K, Voboril Z. Immunoscintigraphy and intra-operative radioimmunodetection in the treatment of colorectal carcinoma. Colorectal Dis. 2001;3:380–6.

    Article  CAS  PubMed  Google Scholar 

  117. Collier BD, Abdel-Nabi H, Doerr RJ, Harwood SJ, Olsen J, Kaplan EH, Winzelberg GG, Grossman SJ, Krag DN, Mitchell EP. Immunoscintigraphy performed with In-111-labeled CYT-103 in the management of colorectal cancer: comparison with CT. Radiology. 1992;185:179–86.

    Article  CAS  PubMed  Google Scholar 

  118. Arnold MW, Schneebaum S, Berens A, Petty L, Mojzisik C, Hinkle G, Martin Jr EW. Intraoperative detection of colorectal cancer with radioimmunoguided surgery and CC49, a second-generation monoclonal antibody. Ann Surg. 1992;216:627–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  119. Arnold MW, Schneebaum S, Berens A, Mojzisik C, Hinkle G, Martin Jr EW. Radioimmunoguided surgery challenges traditional decision making in patients with primary colorectal cancer. Surgery. 1992;112:624–9; discussion 629–30.

    CAS  PubMed  Google Scholar 

  120. Arnold MW, Young DC, Hitchcock CL, Schneebaum S, Martin Jr EW. Radioimmunoguided surgery in primary colorectal carcinoma: an intraoperative prognostic tool and adjuvant to traditional staging. Am J Surg. 1995;170:315–8.

    Article  CAS  PubMed  Google Scholar 

  121. Bertsch DJ, Burak WE, Young DC, Arnold MW, Martin Jr EW. Radioimmunoguided surgery system improves survival for patients recurrent colorectal cancer. Surgery. 1995;118:634–8.

    Article  CAS  PubMed  Google Scholar 

  122. Arnold MW, Hitchcock CL, Young DC, Burak Jr WE, Bertsch DJ, Martin Jr EW. Intra-abdominal patterns of disease dissemination in colorectal cancer identified using radioimmunoguided surgery. Dis Colon Rectum. 1996;39:509–13.

    Article  CAS  PubMed  Google Scholar 

  123. Bertsch DJ, Burak Jr WE, Young DC, Arnold MW, Martin Jr EW. Radioimmunoguided surgery for colorectal cancer. Ann Surg Oncol. 1996;3:310–6.

    Article  CAS  PubMed  Google Scholar 

  124. Arnold MW, Young DC, Hitchcock CL, Barberá-Guillem E, Nieroda C, Martin Jr EW. Staging of colorectal cancer: biology vs. morphology. Dis Colon Rectum. 1998;41:1–6.

    Article  Google Scholar 

  125. Manayan RC, Hart MJ, Friend WG. Radioimmunoguided surgery for colorectal cancer. Am J Surg. 1997;173:386–9.

    Article  CAS  PubMed  Google Scholar 

  126. Schneebaum S, Papo J, Graif M, Baratz M, Baron J, Skornik Y. Radioimmunoguided surgery benefits for recurrent colorectal cancer. Ann Surg Oncol. 1997;4:371–6.

    Article  CAS  PubMed  Google Scholar 

  127. Avital S, Haddad R, Troitsa A, Kashtan H, Brazovsky E, Gitstein G, Skornick Y, Schneebaum S. Radioimmunoguided surgery for recurrent colorectal cancer manifested by isolated CEA elevation. Cancer. 2000;89:1692–8.

    Article  CAS  PubMed  Google Scholar 

  128. Schneebaum S, Troitsa A, Avital S, Haddad R, Kashtan H, Gitstein G, Baratz M, Brazovsky E, Papo J, Skornick Y. Identification of lymph node metastases in recurrent colorectal cancer. Recent Results Cancer Res. 2000;157:281–92.

    Article  CAS  PubMed  Google Scholar 

  129. Haddad R, Avital S, Troitsa A, Chen J, Baratz M, Brazovsky E, Gitstein G, Kashtan H, Skornick Y, Schneebaum S. Benefits of radioimmunoguided surgery for pelvic recurrence. Eur J Surg Oncol. 2001;27:298–301.

    Article  CAS  PubMed  Google Scholar 

  130. Schneebaum S, Troitsa A, Haddad R, Avital S, Kashtan H, Baratz M, Brazovsky E, Papo J, Skornick Y. Immunoguided lymph node dissection in colorectal cancer: a new challenge? World J Surg. 2001;25:1495–8; discussion 1499.

    Article  CAS  PubMed  Google Scholar 

  131. Quinlan D, Davidson A, Gamponia E, Lindley J, Doshi H. Detection of tumor-associated glycoprotein-72 (TAG-72) in short-term and long-term surviving colon cancer patients using a first- and second-generation monoclonal antibody. Proc Am Assoc Cancer Res. 1991;32:271.

    Google Scholar 

  132. Burak Jr WE, Schneebaum S, Kim JA, Arnold MW, Hinkle G, Berens A, Mojzisik C, Martin Jr EW. Pilot study evaluating the intraoperative localization of radiolabeled monoclonal antibody CC83 in patients with metastatic colorectal carcinoma. Surgery. 1995;118:103–8.

    Article  PubMed  Google Scholar 

  133. Povoski SP, Hatzaras IS, Mojzisik CM, Arnold MW, Hinkle GH, Hitchcock CL, Young DC, Martin Jr EW. Antigen-directed cancer surgery for primary colorectal cancer: 15-year survival analysis. Ann Surg Oncol. 2012;19:131–8.

    Article  PubMed  Google Scholar 

  134. Agnese DM, Abdessalam SF, Burak WE, Arnold MW, Soble D, Hinkle GH, Young D, Kazaeli MB, Martin Jr EW. Pilot study using a humanized CC49 monoclonal antibody (HuCC49∆CH2) to localize recurrent colorectal carcinoma. J Surg Oncol. 2004;11:197–202.

    Article  Google Scholar 

  135. Curtet C, Vuillez JP, Daniel G, Aillet G, Chetanneau A, Visset J, Kremer M, Thédrez P, Chatal JF. Feasibility study of radioimmunoguided surgery of colorectal carcinomas using indium-111 CEA-specific monoclonal antibody. Eur J Nucl Med. 1990;17:299–304.

    Article  CAS  PubMed  Google Scholar 

  136. Lechner P, Lind P, Binter G. Tc-99m-labeled anti-CEA antibodies in intraoperative diagnosis of colorectal cancer. Nuklearmedizin. 1995;34:8–14. [German].

    CAS  PubMed  Google Scholar 

  137. Lechner P. Probe-guided surgery of colorectal carcinoma. Acta Med Austriaca. 1997;24:68–72. [German].

    CAS  PubMed  Google Scholar 

  138. Lechner P, Lind P, Snyder M, Haushofer H. Probe-guided surgery for colorectal cancer. Recent Results Cancer Res. 2000;157:273–80.

    Article  CAS  PubMed  Google Scholar 

  139. Mayer A, Tsiompanou E, O’Malley D, Boxer GM, Bhatia J, Flynn AA, Chester KA, Davidson BR, Lewis AA, Winslet MC, Dhillon AP, Hilson AJ, Begent RH. Radioimmunoguided surgery in colorectal cancer using a genetically engineered anti-CEA single-chain Fv antibody. Clin Cancer Res. 2000;6:1711–9.

    CAS  PubMed  Google Scholar 

  140. Gioffrè Florio MA, Baldari S, Famà F, Giacobbe G, Pollicino A. Radioimmunoguided surgery (R.I.G.S.) in colorectal cancer. Preliminary results. Chir Ital. 2002;54:323–9. [Italian].

    PubMed  Google Scholar 

  141. Gioffrè Florio MA, Famà F, Gullo G, Mazzei S, Pollicino A, Scarfò P, Vindigni A. Personal experience using radioimmunoguided surgery (RIGS). Ann Ital Chir. 2007;78:433–7. [Italian].

    PubMed  Google Scholar 

  142. Strong VE, Humm J, Russo P, Jungbluth A, Wong WD, Daghighian F, Old L, Fong Y, Larson SM. A novel method to localize antibody-targeted cancer deposits intraoperatively using handheld PET beta and gamma probes. Surg Endosc. 2008;22:386–91.

    Article  PubMed  Google Scholar 

  143. de Nardi P, Stella M, Magnani P, Paganelli G, Mangili F, Fazio F, di Carlo V. Combination of monoclonal antibodies for radioimmunoguided surgery. Int J Colorectal Dis. 1997;12:24–8.

    Article  PubMed  Google Scholar 

  144. Xu G, Zhang M, Liu B, Li Z, Lin B, Xu X, Jin M, Li J, Wu J, Dong Z. Radioimmunoguided surgery in gastric cancer using 131-I labeled monoclonal antibody 3H11. Semin Surg Oncol. 1994;10:88–94.

    Article  CAS  PubMed  Google Scholar 

  145. Liu BG, Xu GW, Zhang MY. A clinical trial of radioimmunoguided surgery for gastric cancer. Zhonghua Zhong Liu Za Zhi. 1994;16:284–7. [Chinese].

    CAS  PubMed  Google Scholar 

  146. Lucisano E, Bertoglio S. Role of radioimmunoguided surgery using iodine-125-labeled B72.3 monoclonal antibody in gastric cancer surgery. Semin Surg Oncol. 1998;15:212–4.

    Article  CAS  PubMed  Google Scholar 

  147. Mussa A, Sandrucci S, Mobiglia A, Baccega M, Mussa B, De Filippi PG. Role of radioimmunolocalization in the staging of gastric carcinoma. Semin Surg Oncol. 1998;15:209–11.

    Article  CAS  PubMed  Google Scholar 

  148. Wang C, Wang Y, Su X, Lin B, Xu X, Zhang M, Li J, Xu G. Iodine-125 labeled monoclonal antibody 3H11: in radioimmunoguided surgery for primary gastric cancer. Zhonghua Wai Ke Za Zhi. 2000;38:507–9. [Chinese].

    CAS  PubMed  Google Scholar 

  149. LaValle GJ, Martinez DA, Sobel D, DeYoung B, Martin Jr EW. Assessment of disseminated pancreatic cancer: a comparison of traditional exploratory laparotomy and radioimmunoguided surgery. Surgery. 1997;122:867–71; discussion 871–3.

    Article  CAS  PubMed  Google Scholar 

  150. Nieroda CA, Mojzisik C, Sardi A, Farrar WB, Hinkle G, Siddiqi MA, Ferrara PJ, James A, Schlom J, Thurston MO, Martin Jr EW. Staging of carcinoma of the breast using a hand-held gamma detecting probe and monoclonal antibody B72.3. Surg Gynecol Obstet. 1989;169:35–40.

    CAS  PubMed  Google Scholar 

  151. Percivale P, Bertoglio S, Meszaros P, Canavese G, Cafiero F, Gipponi M, Campora E, Gasco M, Badellino F. Radioimmunoguided surgery after primary treatment of locally advanced breast cancer. J Clin Oncol. 1996;14:1599–603.

    CAS  PubMed  Google Scholar 

  152. Badellino F, Bertoglio S, Mariani G, Meszaros P, Canavese G, Percivale P. Use of radioimmunoguided surgery after induction chemotherapy in locally advanced breast cancer. Semin Surg Oncol. 1998;15:245–8.

    Article  CAS  PubMed  Google Scholar 

  153. Burak Jr WE, DePalatis L, Mosic JL, Soble D, Hinkle G, Hitchcock CL. Radioimmunoguided breast surgery using radiolabeled antibody NR-LU-10 FAB: a pilot study. Tumori. 2001;87:142–6.

    PubMed  Google Scholar 

  154. Gitsch E, Pateisky N, Schatten C. Diagnostic and intraoperative immunoscintigraphy in ovarian cancer. Eur J Obstet Gynecol Reprod Biol. 1989;32:33–7.

    Article  CAS  PubMed  Google Scholar 

  155. Gitsch E, Pateisky N. Radio-immunoscintigraphy and intraoperative tumour detection by means of anti-tumour antibodies in patients with ovarian cancer. Baillieres Clin Obstet Gynaecol. 1989;3:31–6.

    Article  CAS  PubMed  Google Scholar 

  156. Pateisky N, Gitsch E. Immunoscintigraphy and intraoperative tumor search in ovarian cancer. Arch Gynecol Obstet. 1989;245:606–9. [German].

    Article  CAS  PubMed  Google Scholar 

  157. Bell J, Mojzisik C, Hinkle Jr G, Derman H, Schlom J, Martin E. Intraoperative radioimmunodetection of ovarian cancer using monoclonal antibody B72.3 and a portable gamma-detecting probe. Obstet Gynecol. 1990;76:607–11.

    CAS  PubMed  Google Scholar 

  158. Jäger W, Feistel H, Paterok EM, Ronay G, Tulusan AH, Wolf F, Lang N. Resection guided by antibodies (REGAJ): a diagnostic procedure during second-look operation in ovarian cancer patients. Br J Cancer Suppl. 1990;10:18–20.

    PubMed  Google Scholar 

  159. Ind TE, Granowska M, Britton KE, Morris G, Lowe DG, Hudson CN, Shepherd JH. Peroperative radioimmunodetection of ovarian carcinoma using a hand-held gamma detection probe. Br J Cancer. 1994;70:1263–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  160. McIntosh DG, Colcher D, Seemayer T, Smith ML. The intraoperative detection of ovarian adenocarcinoma using radiolabeled CC49 monoclonal antibody and a hand-held gamma-detecting probe. Cancer Biother Radiopharm. 1997;12:287–94.

    CAS  PubMed  Google Scholar 

  161. Badalament RA, Burgers JK, Petty LR, Mojzisik CM, Berens A, Marsh W, Hinkle GH, Martin Jr EW. Radioimmunoguided radical prostatectomy and lymphadenectomy. Cancer. 1993;71:2268–75.

    Article  CAS  PubMed  Google Scholar 

  162. Anderson RS, Eifert B, Tartt S, King P. Radioimmunoguided surgery using indium-111 capromab pendetide (PROSTASCINT) to diagnose supraclavicular metastasis from prostate cancer. Urology. 2000;56:669xii–v.

    Article  Google Scholar 

  163. Grazia M, Bini A, Stella F, Pagani D, Bazzocchi R. Radioimmunoguided surgery and intraoperative lung cancer staging. Semin Surg Oncol. 1998;15:215–9.

    Article  CAS  PubMed  Google Scholar 

  164. Mansi L, Di Lieto E, Rambaldi PF, Bergaminelli C, Fallanca F, Vicidomini G, Cuccurullo V, Mancusi R. Preliminary experience with radioimmuno-guided surgery of primary neoplasms of the lung. Minerva Chir. 1998;53:369–72. [Italian].

    CAS  PubMed  Google Scholar 

  165. Argenzio V, Rambaldi PF, Iorio G, Cuccurullo V, Cascini G, Argenzio G, Mansi L. Radioimmunoguided surgery in squamous cell carcinoma. J Am Soc Plast Surg. 1999;103:749–51.

    CAS  Google Scholar 

  166. Peltier P, Curtet C, Chatal JF, Le Doussal JM, Daniel G, Aillet G, Gruaz-Guyon A, Barbet J, Delaage M. Radioimmunodetection of medullary thyroid cancer using a bispecific anti-CEA/anti-indium-DTPA antibody and an indium-111-labeled DTPA dimer. J Nucl Med. 1993;34:1267–73.

    CAS  PubMed  Google Scholar 

  167. Barbet J, Peltier P, Bardet S, Vuillez JP, Bachelot I, Denet S, Olivier P, Leccia F, Corcuff B, Huglo D, Proye C, Rouvier E, Meyer P, Chatal JF. Radioimmunodetection of medullary thyroid carcinoma using indium-111 bivalent hapten and anti-CEA x anti-DTPA-indium bispecific antibody. J Nucl Med. 1998;39:1172–8.

    CAS  PubMed  Google Scholar 

  168. de Labriolle-Vaylet C, Cattan P, Sarfati E, Wioland M, Billotey C, Brochériou C, Rouvier E, de Roquancourt A, Rostène W, Askienazy S, Barbet J, Milhaud G, Gruaz-Guyon A. Successful surgical removal of occult metastases of medullary thyroid carcinoma recurrences with the help of immunoscintigraphy and radioimmunoguided surgery. Clin Cancer Res. 2000;6:363–71.

    PubMed  Google Scholar 

  169. Houchens D, Cote R, Saad A, Nines R, Berens A, Sampsel J, Crockford D, Schneebaum S, Arnold M, Martin Jr E. Presence of occult tumor detected by 125I-labeled monoclonal antibody CC49. Proc AACR. 1992;33:317.

    Google Scholar 

  170. Houchens D, Cote R, Saad A, Nines R, Berens A, Crockford D, Rojas-Corona R. Schneebaum S, Arnold M, Martin E, Jr. Radioimmunoguided surgery in colorectal cancer: histologic and immunohistochemical analysis of lymph nodes from patients injected with 125I-labeled monoclonal antibody CC49. Presented at the Seventh International Conference on Monoclonal Antibody Immunoconjugates for Cancer, San Diego; 5–7 Mar 1992.

    Google Scholar 

  171. Stephens AD, Punja U, Sugarbaker PH. False-positive lymph nodes by radioimmunoguided surgery: report of a patient and analysis of the problem. J Nucl Med. 1993;34:804–8.

    CAS  PubMed  Google Scholar 

  172. Greenson JK, Isenhart CE, Rice R, Mojzisik C, Houchens D, Martin Jr EW. Identification of occult micrometastases in pericolic lymph nodes of Duke’s B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49. Correlation with long-term survival. Cancer. 1994;73:563–9.

    Article  CAS  PubMed  Google Scholar 

  173. Hitchcock CL, Greenson JK, Sampsel JW, Houchens DP, Saad AD, Isenhart CE Schneebaum S, Seethi S, Cote RJ. RIGS pathology and the biologic staging of colorectal cancer. In: Martin EW, editor. Radioimmunoguided surgery (RIGS) in the detection and treatment of colorectal cancer. 1st ed. Austin: R.G. Landes Company; 1994. p. 147–60.

    Google Scholar 

  174. Schneebaum S, Arnold MW, Houchens DP, Greenson JK, Cote RJ, Hitchcock CL, Young DC, Mojzisik CM, Martin Jr EW. The significance of intraoperative periportal lymph node metastasis identification in patients with colorectal carcinoma. Cancer. 1995;75:2809–17.

    Article  CAS  PubMed  Google Scholar 

  175. Hitchcock CL, Arnold MW, Young DC, Schneebaum S, Martin Jr EW. TAG-72 expression in lymph nodes and RIGS. Dis Colon Rectum. 1996;39:473–5.

    Article  CAS  PubMed  Google Scholar 

  176. Cote RJ, Houchens DP, Hitchcock CL, Saad AD, Nines RG, Greenson JK, Schneebaum S, Arnold MW, Martin Jr EW. Intraoperative detection of occult colon cancer micrometastases using 125 I-radiolabled monoclonal antibody CC49. Cancer. 1996;77:613–20.

    Article  CAS  PubMed  Google Scholar 

  177. Barbera-Guillem E, Arnold MW, Nelson MB, Martin Jr EW. First results for resetting the antitumor immune response by immune corrective surgery in colon cancer. Am J Surg. 1998;176:339–43.

    Article  CAS  PubMed  Google Scholar 

  178. Abdel Nabi H, Doerr RJ, Balu D, Rogan L, Farrell EL, Evans NH. Gamma probe assisted ex vivo detection of small lymph node metastases following the administration of indium-111-labeled monoclonal antibodies to colorectal cancers. J Nucl Med. 1993;34:1818–22.

    CAS  PubMed  Google Scholar 

  179. Sézeur A, Châtelet FP, Cywiner C, de Labriolle-Vaylet C, Chastang C, Billotey C, Malafosse M, Gallot D, Betton P, Montravers F, Carvajal-Gonzalez S, Askienazy S, Talbot JN, Rain JD, Milhaud G, Saumon G, Barbet J, Gruaz-Guyon A. Pathology underrates colon cancer extranodal and nodal metastases; ex vivo radioimmunodetection helps staging. Clin Cancer Res. 2007;13(18 Pt 2):5592s–7.

    Article  PubMed  CAS  Google Scholar 

  180. Povoski SP, Hatzaras IS, Mojzisik CM, Martin Jr EW. Oncologic theranostics: recognition of this concept in antigen-directed cancer therapy for colorectal cancer with anti-TAG-72 monoclonal antibodies. Expert Rev Mol Diagn. 2011;11:667–70.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA

    Stephen P. Povoski MD & Cathy M. Mojzisik RN, BSN, MS

  2. Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, 43210, USA

    Brandon J. Sullivan PhD

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  1. Stephen P. Povoski MD
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  1. Universitätsklinikum Würzburg, Department of Nuclear Medicine, Würzburg, Germany

    Ken Herrmann

  2. The University of Sydney, Melanoma Institute Australia, North Sydney, New South Wales, Australia

    Omgo E. Nieweg

  3. Arthur G. James Canc Hosp Richard J. Sol, The Ohio State Univ Comp Canc CTR, Columbus, Ohio, USA

    Stephen P. Povoski

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Povoski, S.P., Mojzisik, C.M., Sullivan, B.J. (2016). Radioimmunoguided Surgery: Intraoperative Radioimmunodetection for the Radioguided Localization and Resection of Tumors. In: Herrmann, K., Nieweg, O., Povoski, S. (eds) Radioguided Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-26051-8_24

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