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Radioguided Sentinel Lymph Node Mapping and Biopsy in Non-small Cell Lung Cancer (NSCLC)

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Radioguided Surgery

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Abstract

Mediastinal lymph node dissection is an integral part of non-small cell lung cancer (NSCLC) surgical treatment. However, mediastinal lymph nodes are involved in less than 30 % of clinically stage I patients. Sentinel lymph node (SLN) mapping and biopsy has been proposed as an alternative to mediastinal lymph node dissection in NSCLC since 1999. Most studies thus far have used radiotracers for lymphatic mapping in NSCLC. Successful SLN mapping and biopsy needs careful selection of patients (only cN0 patients without history of chemotherapy) and proper administration route of the radiotracer (peri-tumoral is preferred over intra-tumoral injections). Alternative methods such as magnetic particles and fluorescent dyes seem to be very promising and need further validation studies in the future.

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Authors and Affiliations

  1. Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Leili Zarifmahmoudi PhD, Ramin Sadeghi MD & Susan Shafiee MD

  2. Division of Surgical Oncology, Department of Surgery, College of Medicine, University of Vermont Given Building, Rm E309, 89 Beaumont Ave, Burlington, VT, 05405, USA

    David N. Krag MD

  3. Endoscopic & Minimal Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Reza Bagheri MD

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  1. Leili Zarifmahmoudi PhD
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Correspondence to David N. Krag MD .

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  1. Universitätsklinikum Würzburg, Department of Nuclear Medicine, Würzburg, Germany

    Ken Herrmann

  2. The University of Sydney, Melanoma Institute Australia, North Sydney, New South Wales, Australia

    Omgo E. Nieweg

  3. Arthur G. James Canc Hosp Richard J. Sol, The Ohio State Univ Comp Canc CTR, Columbus, Ohio, USA

    Stephen P. Povoski

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Zarifmahmoudi, L., Krag, D.N., Sadeghi, R., Bagheri, R., Shafiee, S. (2016). Radioguided Sentinel Lymph Node Mapping and Biopsy in Non-small Cell Lung Cancer (NSCLC). In: Herrmann, K., Nieweg, O., Povoski, S. (eds) Radioguided Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-26051-8_20

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