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AMP-Activated Protein Kinase and l-Arginine

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L-Arginine in Clinical Nutrition

Part of the book series: Nutrition and Health ((NH))

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Abstract

l-Arginine (ARG) is a cationic, conditionally essential amino acid that is involved in numerous physiological processes [Durante et al. (Clin Exp Pharmacol Physiol 34:906–911, 2007)]. It plays an important role not only in removing ammonia from the body but also in cell division, wound healing, immune function, and hormone release. l-Arginine also serves as the precursor for the synthesis of l-Ornithine, l-Proline, polyamines, agmantine, creatine, and protein [Barbul (JPEN J Parenter Enteral Nutr 10:227–238, 1986); Wu and Morris (Biochem J 336:1–17, 1998)] (Fig. 3.1). But more significantly, ARG is known to be the exclusive substrate for nitric oxide synthase (NOS), which utilizes ARG to generate the signaling molecule, nitric oxide (NO) [Palmer et al. (Nature 333:664–666, 1988)].

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Authors and Affiliations

  1. University of New England, 716 Stevens Avenue, Portland, ME, 04103, USA

    Srinidi Mohan PhD

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  1. Srinidi Mohan PhD
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Correspondence to Srinidi Mohan PhD .

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  1. Faculty of Science & Technology Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

  2. Department Nutrition and Dietetics Nutritional Sciences Division School of Biomedical & Health Sciences, King’s College London, London, United Kingdom

    Victor R. Preedy

  3. Nutritional Sciences Research Division Faculty of Life Science and Medicine, King’s College London, London, United Kingdom

    Rajkumar Rajendram

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Mohan, S. (2017). AMP-Activated Protein Kinase and l-Arginine. In: Patel, V., Preedy, V., Rajendram, R. (eds) L-Arginine in Clinical Nutrition. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-319-26009-9_3

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  • DOI: https://doi.org/10.1007/978-3-319-26009-9_3

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