Abstract
Constipation is a prevalent condition that can have significant effects on quality of life. Initial treatment should include behavioral modification and fiber supplementation or laxatives. In patients that require further intervention, testing modalities are available to aid in differentiating between constipation subtypes. For patients with slow transit constipation, confirmed by transit studies, prescription medications are available which may improve symptoms. Those who do not respond favorably may be candidates for surgical intervention, which is most commonly a total abdominal colectomy. Most importantly, management strategies for constipation must be tailored to the individual patient.
References
Higgins PD, Johanson JF. Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol. 2004;99(4):750–9.
Sonnenberg A, Koch TR. Physician visits in the United States for constipation: 1958 to 1986. Dig Dis Sci. 1989;34(4):606–11.
Ribas Y, et al. Prevalence and pathophysiology of functional constipation among women in Catalonia, Spain. Dis Colon Rectum. 2011;54(12):1560–9.
Knowles CH, et al. Idiopathic slow-transit constipation: an almost exclusively female disorder. Dis Colon Rectum. 2003;46(12):1716–7.
Harari D, Gurwitz JH, Minaker KL. Constipation in the elderly. J Am Geriatr Soc. 1993;41(10):1130–40.
Sandler RS, Jordan MC, Shelton BJ. Demographic and dietary determinants of constipation in the US population. Am J Public Health. 1990;80(2):185–9.
Johanson JF, Sonnenberg A, Koch TR. Clinical epidemiology of chronic constipation. J Clin Gastroenterol. 1989;11(5):525–36.
Talley NJ, et al. Constipation in an elderly community: a study of prevalence and potential risk factors. Am J Gastroenterol. 1996;91(1):19–25.
Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology. 2006;130(5):1377–90.
Longstreth GF, et al. Functional bowel disorders. Gastroenterology. 2006;130(5):1480–91.
Rao SS, et al. Dyssynergic defecation: demographics, symptoms, stool patterns, and quality of life. J Clin Gastroenterol. 2004;38(8):680–5.
Hinton JM, Lennard-Jones JE, Young AC. A ne method for studying gut transit times using radioopaque markers. Gut. 1969;10(10):842–7.
Metcalf AM, et al. Simplified assessment of segmental colonic transit. Gastroenterology. 1987;92(1):40–7.
Cowlam S, et al. Validity of segmental transit studies used in routine clinical practice, to characterize defaecatory disorder in patients with functional constipation. Colorectal Dis. 2008;10(8):818–22.
Nam YS, et al. Reproducibility of colonic transit study in patients with chronic constipation. Dis Colon Rectum. 2001;44(1):86–92.
Eising EG, von der Ohe MR. Differentiation of prolonged colonic transit using scintigraphy with indium-111-labeled polystyrene pellets. J Nucl Med. 1998;39(6):1062–6.
Manabe N, et al. Lower functional gastrointestinal disorders: evidence of abnormal colonic transit in a 287 patient cohort. Neurogastroenterol Motil. 2010;22(3):293–e82.
Rao SS, et al. Investigation of colonic and whole-gut transit with wireless motility capsule and radiopaque markers in constipation. Clin Gastroenterol Hepatol. 2009;7(5):537–44.
Camilleri M, et al. Wireless pH-motility capsule for colonic transit: prospective comparison with radiopaque markers in chronic constipation. Neurogastroenterol Motil. 2010;22(8):874–82. e233.
Tobon F, et al. Nonsurgical test for the diagnosis of Hirschsprung’s disease. N Engl J Med. 1968;278(4):188–93.
Harari D, et al. Bowel habit in relation to age and gender. Findings from the National Health Interview Survey and clinical implications. Arch Intern Med. 1996;156(3):315–20.
Longstreth GF. Bowel patterns and anxiety. Demographic factors. J Clin Gastroenterol. 1993;17(2):128–32.
De Schryver AM, et al. Effects of regular physical activity on defecation pattern in middle-aged patients complaining of chronic constipation. Scand J Gastroenterol. 2005;40(4):422–9.
Rao SS, et al. Effects of acute graded exercise on human colonic motility. Am J Physiol. 1999;276(5 Pt 1):G1221–6.
Tuteja AK, et al. Is constipation associated with decreased physical activity in normally active subjects? Am J Gastroenterol. 2005;100(1):124–9.
Muller-Lissner SA, et al. Myths and misconceptions about chronic constipation. Am J Gastroenterol. 2005;100(1):232–42.
Anti M, et al. Water supplementation enhances the effect of high-fiber diet on stool frequency and laxative consumption in adult patients with functional constipation. Hepatogastroenterology. 1998;45(21):727–32.
Ashraf W, et al. Effects of psyllium therapy on stool characteristics, colon transit and anorectal function in chronic idiopathic constipation. Aliment Pharmacol Ther. 1995;9(6):639–47.
Castle SC, et al. Constipation prevention: empiric use of stool softeners questioned. Geriatrics. 1991;46(11):84–6.
Johanson JF, et al. Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation. Am J Gastroenterol. 2008;103(1):170–7.
Johanson JF, Ueno R. Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safety. Aliment Pharmacol Ther. 2007;25(11):1351–61.
Johnston JM, et al. Pilot study on the effect of linaclotide in patients with chronic constipation. Am J Gastroenterol. 2009;104(1):125–32.
Lembo AJ, et al. Efficacy of linaclotide for patients with chronic constipation. Gastroenterology. 2010;138(3):886–95. e1.
Yuan CS, et al. Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: a double-blind randomized placebo-controlled trial. J Pharmacol Exp Ther. 2002;300(1):118–23.
Thomas J, et al. Methylnaltrexone for opioid-induced constipation in advanced illness. N Engl J Med. 2008;358(22):2332–43.
Webster L, et al. Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain. Pain. 2008;137(2):428–40.
Foxx-Orenstein AE, et al. Does co-administration of a non-selective opiate antagonist enhance acceleration of transit by a 5-HT4 agonist in constipation-predominant irritable bowel syndrome? a randomized controlled trial. Neurogastroenterol Motil. 2007;19(10):821–30.
Sloots CE, et al. Effects of prucalopride on colonic transit, anorectal function and bowel habits in patients with chronic constipation. Aliment Pharmacol Ther. 2002;16(4):759–67.
Emmanuel AV, et al. Prucalopride, a systemic enterokinetic, for the treatment of constipation. Aliment Pharmacol Ther. 2002;16(7):1347–56.
Redmond JM, et al. Physiological tests to predict long-term outcome of total abdominal colectomy for intractable constipation. Am J Gastroenterol. 1995;90(5):748–53.
Ho YH, et al. Laparoscopic-assisted compared with open total colectomy in treating slow transit constipation. Aust N Z J Surg. 1997;67(8):562–5.
Athanasakis H, et al. Laparoscopically assisted subtotal colectomy for slow-transit constipation. Surg Endosc. 2001;15(10):1090–2.
Webster C, Dayton M. Results after colectomy for colonic inertia: a sixteen-year experience. Am J Surg. 2001;182(6):639–44.
Pikarsky AJ, et al. Long-term follow-up of patients undergoing colectomy for colonic inertia. Dis Colon Rectum. 2001;44(2):179–83.
Sarli L, et al. The rationale for cecorectal anastomosis for slow transit constipation. Acta Biomed. 2003;74 Suppl 2:74–9.
Marchesi F, et al. Subtotal colectomy with antiperistaltic cecorectal anastomosis in the treatment of slow-transit constipation: long-term impact on quality of life. World J Surg. 2007;31(8):1658–64.
Feng Y, Jianjiang L. Functional outcomes of two types of subtotal colectomy for slow-transit constipation: ileosigmoidal anastomosis and cecorectal anastomosis. Am J Surg. 2008;195(1):73–7.
Knowles CH, Scott M, Lunniss PJ. Outcome of colectomy for slow transit constipation. Ann Surg. 1999;230(5):627–38.
FitzHarris GP, et al. Quality of life after subtotal colectomy for slow-transit constipation: both quality and quantity count. Dis Colon Rectum. 2003;46(4):433–40.
Thaler K, et al. Quality of life after colectomy for colonic inertia. Tech Coloproctol. 2005;9(2):133–7.
Zutshi M, et al. Surgery for slow transit constipation: are we helping patients? Int J Colorectal Dis. 2007;22(3):265–9.
Bernini A, et al. Should patients with combined colonic inertia and nonrelaxing pelvic floor undergo subtotal colectomy? Dis Colon Rectum. 1998;41(11):1363–6.
Reshef A, et al. Colectomy for slow transit constipation: effective for patients with coexistent obstructed defecation. Int J Colorectal Dis. 2013;28(6):841–7.
Zmora O, et al. Small bowel transit does not correlate with outcome of surgery in patients with colonic inertia. Surg Innov. 2005;12(3):215–8.
Mollen RM, Kuijpers HC, Claassen AT. Colectomy for slow-transit constipation: preoperative functional evaluation is important but not a guarantee for a successful outcome. Dis Colon Rectum. 2001;44(4):577–80.
Glia A, Akerlund JE, Lindberg G. Outcome of colectomy for slow-transit constipation in relation to presence of small-bowel dysmotility. Dis Colon Rectum. 2004;47(1):96–102.
O’Brien S, et al. Sexual abuse: a strong predictor of outcomes after colectomy for slow-transit constipation. Dis Colon Rectum. 2009;52(11):1844–7.
Kamm MA, et al. Left hemicolectomy with rectal excision for severe idiopathic constipation. Int J Colorectal Dis. 1991;6(1):49–51.
de Graaf EJ, Gilberts EC, Schouten WR. Role of segmental colonic transit time studies to select patients with slow transit constipation for partial left-sided or subtotal colectomy. Br J Surg. 1996;83(5):648–51.
You YT, et al. Segmental colectomy in the management of colonic inertia. Am Surg. 1998;64(8):775–7.
Lundin E, et al. Outcome of segmental colonic resection for slow-transit constipation. Br J Surg. 2002;89(10):1270–4.
Ripetti V, et al. Is total colectomy the right choice in intractable slow-transit constipation? Surgery. 2006;140(3):435–40.
Keighley MR, Grobler S, Bain I. An audit of restorative proctocolectomy. Gut. 1993;34(5):680–4.
Kalbassi MR, Winter DC, Deasy JM. Quality-of-life assessment of patients after ileal pouch-anal anastomosis for slow-transit constipation with rectal inertia. Dis Colon Rectum. 2003;46(11):1508–12.
El-Tawil AM. Reasons for creation of permanent ileostomy for the management of idiopathic chronic constipation. J Gastroenterol Hepatol. 2004;19(8):844–6.
Scarpa M, Barollo M, Keighley MR. Ileostomy for constipation: long-term postoperative outcome. Colorectal Dis. 2005;7(3):224–7.
Malone PS, Ransley PG, Kiely EM. Preliminary report: the antegrade continence enema. Lancet. 1990;336(8725):1217–8.
Squire R, et al. The clinical application of the Malone antegrade colonic enema. J Pediatr Surg. 1993;28(8):1012–5.
Kim SM, Han SW, Choi SH. Left colonic antegrade continence enema: experience gained from 19 cases. J Pediatr Surg. 2006;41(10):1750–4.
Patton V, Lubowski DZ. Clinical outcome and efficacy of antegrade colonic enemas administered via an indwelling cecostomy catheter in adults with defecatory disorders. Dis Colon Rectum. 2015;58(4):457–62.
Gerharz EW, et al. The value of the MACE (Malone antegrade colonic enema) procedure in adult patients. J Am Coll Surg. 1997;185(6):544–7.
Rongen MJ, van der Hoop AG, Baeten CG. Cecal access for antegrade colon enemas in medically refractory slow-transit constipation: a prospective study. Dis Colon Rectum. 2001;44(11):1644–9.
Poirier M, Abcarian H, Nelson R. Malone antegrade continent enema: an alternative to resection in severe defecation disorders. Dis Colon Rectum. 2007;50(1):22–8.
Lees NP, et al. Long-term results of the antegrade continent enema procedure for constipation in adults. Colorectal Dis. 2004;6(5):362–8.
Worsoe J, et al. Long-term results of antegrade colonic enema in adult patients: assessment of functional results. Dis Colon Rectum. 2008;51(10):1523–8.
Dinning PG, et al. Sacral nerve stimulation induces pan-colonic propagating pressure waves and increases defecation frequency in patients with slow-transit constipation. Colorectal Dis. 2007;9(2):123–32.
Kenefick NJ, et al. Double-blind placebo-controlled crossover study of sacral nerve stimulation for idiopathic constipation. Br J Surg. 2002;89(12):1570–1.
Dinning PG, et al. Pancolonic motor response to subsensory and suprasensory sacral nerve stimulation in patients with slow-transit constipation. Br J Surg. 2012;99(7):1002–10.
Govaert B, et al. Medium-term outcome of sacral nerve modulation for constipation. Dis Colon Rectum. 2012;55(1):26–31.
Kamm MA, et al. Sacral nerve stimulation for intractable constipation. Gut. 2010;59(3):333–40.
Ortiz H, et al. Functional outcome of sacral nerve stimulation in patients with severe constipation. Dis Colon Rectum. 2012;55(8):876–80.
Graf W, et al. Results after sacral nerve stimulation for chronic constipation. Neurogastroenterol Motil. 2015;27(5):734–9.
Lewis SJ, Heaton KW. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol. 1997;32(9):920–4.
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Kapadia, M.R., Varma, M.K. (2016). Evaluation of Constipation and Treatment of Abdominal Constipation. In: Steele, S.R., Hull, T.L., Read, T.E., Saclarides, T.J., Senagore, A.J., Whitlow, C.B. (eds) The ASCRS Textbook of Colon and Rectal Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-25970-3_58
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