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Bioengineering and Cancer Stem Cell Concept pp 57–70Cite as

Cancer Stem Cell Markers: Classification and Their Significance in Cancer Stem Cells

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Abstract

This chapter is dealing with identification of cancer stem cell markers, their latest classification, function in normal and cancer stem cells (CSCs), and their use in development of novel targeted antitumor therapy. It was difficult to prove the CSCs existence, unless the in vivo and in vitro experiments have been done supporting the theory that they have common clonogenic origin and perpetuate always the same phenotypic marker(s) on their surface, being also able to induce production of original tumor in transplanted NOD/SCID mice. The cancer stem cells so far have been found in most of human tissues and checked as well, in agar, for anchorage growth. Today they can be isolated using magnetic beads coated with antibodies targeted against specific markers.

Their tumorigenicity is high, while other cancer cells either do not express it or with a very low intensity. That is why idea of targeted antitumor therapy now has as a goal to target CSCs since in that case the cancer would have been removed forever. Reoccurrence is due to omitting the correct target (CSCs) and targeting other tumor cell and normal tissues. The research in this field is very extensive and requires more knowledge on cellular, molecular, and supramolecular levels.

A thinker sees his own actions as experiments and questions—as attempts to find out something. Success and failure are for him answers above all.

Friedrich Nietzsche

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Authors and Affiliations

  1. Department of Computer and Electrical Engineering and Computer Science, Florida Atlantic University, Boca Raton, FL, USA

    Mirjana Pavlovic

  2. Military Medical Academy Institute for Hematology and Transfusiology, Belgrade, Serbia

    Bela Balint

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  1. Mirjana Pavlovic
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  2. Bela Balint
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Pavlovic, M., Balint, B. (2015). Cancer Stem Cell Markers: Classification and Their Significance in Cancer Stem Cells. In: Bioengineering and Cancer Stem Cell Concept. Springer, Cham. https://doi.org/10.1007/978-3-319-25670-2_4

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  • DOI: https://doi.org/10.1007/978-3-319-25670-2_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-25668-9

  • Online ISBN: 978-3-319-25670-2

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