Delivery Modes for Cardiac Stem Cell Therapy

  • Neil Davies
  • Kyle Goetsch
  • Malebogo Ngoepe
  • Thomas Franz
  • Sandrine Lecour
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)


Stem cell delivery has received considerable attention as a potential therapy for myocardial infarction. However, therapeutic efficacy has been variable and modest in the clinical setting. One potential confounding factor is the poor cardiac retention and engraftment of the injected cells. The various delivery routes are considered with particular reference to their influence on engraftment. Further to that the potential of utilising injectable biomaterials as a strategy for optimizing retention is examined.


Delivery Engraftement Biomaterials Intracoronary infusion Stem cell retention 


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Neil Davies
    • 1
  • Kyle Goetsch
    • 1
  • Malebogo Ngoepe
    • 2
  • Thomas Franz
    • 3
  • Sandrine Lecour
    • 4
  1. 1.Cardiovascular Research Unit, Department of Surgery, Faculty of Health SciencesUniversity of Cape TownObservatorySouth Africa
  2. 2.Department of Mechanical EngineeringUniversity of Cape TownRondeboschSouth Africa
  3. 3.Division of Biomedical Engineering, Department of Human Biology, Faculty of Health SciencesUniversity of Cape TownObservatorySouth Africa
  4. 4.Cardioprotection Group, Hatter Institute for Cardiovascular Research in Africa and MRC Inter-University Cape Heart Group, Faculty of Health SciencesUniversity of Cape TownObservatorySouth Africa

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