Abstract
Contrast-enhanced ultrasound (CEUS) is a harmonic imaging technique that permits to study tissue perfusion and vascularization using a purely intravascular ultrasound contrast agent (UCA). CEUS is a real-time, dynamic, continuous, and repeatable modality, applicable in neurosurgery for tumors and vessels study. In oncological surgery, CEUS permits to highlight and characterize the lesion through the study of its micro- and macro-circulation. Moreover, it allows to assess the degree of tumor removal and to plan the surgical strategy, highlighting the lesion feeders, drainage vessels, and neighboring vital vascular structures. In vascular surgery, CEUS permits to study the entire vascular tree from arteries, through capillaries, to veins simultaneously without the need to set multiple parameters. It also allows to assess vessel location, dimension, and flow entity and direction without the need of vessel direct exposure, being CEUS a tomographic representation. This leads to protect vital structures preservation and also to evaluate the effect of a procedure on the blood circulation.
A previous version of this chapter represented incorrect order of the authors.
For this reason an erratum has been published, correcting the mistake in the previous version and showing the correct order of the authors (see DOI 10.1007/978-3-319-25268-1_15)
An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-25268-1_15
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Piscaglia F, Nolsoe C, Dietrich CF, Cosgrove DO, Gilja OH, Bachmann Nielsen M, Albrecht T, Barozzi L, Bertolotto M, Catalano O, Claudon M, Clevert DA, Correas JM, D’Onofrio M, Drudi FM, Eyding J, Giovannini M, Hocke M, Ignee A, Jung EM, Klauser AS, Lassau N, Leen E, Mathis G, Saftoiu A, Seidel G, Sidhu PS, ter Haar G, Timmerman D, Weskott HP (2012) The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): update 2011 on non-hepatic applications. Ultraschall Med (Stuttgart, Germany: 1980) 33(1):33–59. doi:10.1055/s-0031-1281676
Prada F, Del Bene M, Moiraghi A, Casali C, Legnani FG, Saladino A, Perin A, Vetrano IG, Mattei L, Richetta C, Saini M, DiMeco F (2015) From grey scale B-mode to elastosonography: multimodal ultrasound imaging in meningioma surgery—pictorial essay and literature review. BioMed Res Int 2015:13. doi:10.1155/2015/925729
Prada F, Perin A, Martegani A, Aiani L, Solbiati L, Lamperti M, Casali C, Legnani F, Mattei L, Saladino A, Saini M, DiMeco F (2014) Intraoperative contrast-enhanced ultrasound for brain tumor surgery. Neurosurgery 74(5):542–552. doi:10.1227/neu.0000000000000301; discussion 552
Smirniotopoulos JG, Murphy FM, Rushing EJ, Rees JH, Schroeder JW (2007) Patterns of contrast enhancement in the brain and meninges. RadioGraphics 27(2):525–551. doi:10.1148/rg.272065155
EMA (2014) SonoVue -EMEA/H/C/000303 -II/0025. http://www.ema.europa.eu/ema/index.jsp?
Claudon M, Dietrich CF, Choi BI, Cosgrove DO, Kudo M, Nolsoe CP, Piscaglia F, Wilson SR, Barr RG, Chammas MC, Chaubal NG, Chen MH, Clevert DA, Correas JM, Ding H, Forsberg F, Fowlkes JB, Gibson RN, Goldberg BB, Lassau N, Leen EL, Mattrey RF, Moriyasu F, Solbiati L, Weskott HP, Xu HX (2013) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver – update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultraschall Med (Stuttgart, Germany: 1980) 34(1):11–29. doi:10.1055/s-0032-1325499
Prada F, Del Bene M, Saini M, Ferroli P, DiMeco F (2015) Intraoperative cerebral angiosonography with ultrasound contrast agents: how I do it. Acta Neurochir 157(6):1025–1029. doi:10.1007/s00701-015-2412-x
Prada F, Mattei L, Del Bene M, Aiani L, Saini M, Casali C, Filippini A, Legnani FG, Perin A, Saladino A, Vetrano IG, Solbiati L, Martegani A, DiMeco F (2014) Intraoperative cerebral glioma characterization with contrast enhanced ultrasound. BioMed Res Int 2014:9. doi:10.1155/2014/484261
van Leyen K, Klotzsch C, Harrer JU (2011) Brain tumor imaging with transcranial sonography: state of the art and review of the literature. Ultraschall Med (Stuttgart, Germany: 1980) 32(6):572–581. doi:10.1055/s-0031-1273443
Prada F, Del Bene M, Mattei L, Lodigiani L, DeBeni S, Kolev V, Vetrano I, Solbiati L, Sakas G, DiMeco F (2014) Preoperative magnetic resonance and intraoperative ultrasound fusion imaging for real-time neuronavigation in brain tumor surgery. Ultraschall Med (Stuttgart, Germany: 1980). doi:10.1055/s-0034-1385347
Piscaglia F, Bolondi L (2006) The safety of Sonovue in abdominal applications: retrospective analysis of 23188 investigations. Ultrasound Med Biol 32(9):1369–1375. doi:10.1016/j.ultrasmedbio.2006.05.031
Gibbs V, Cole D, Sassano A (2009) Ultrasound physics and technology. Elsevier, Churchill Livingstone
Quaia E (2011) Assessment of tissue perfusion by contrast-enhanced ultrasound. Eur Radiol 21(3):604–615. doi:10.1007/s00330-010-1965-6
Engelhardt M, Hansen C, Eyding J, Wilkening W, Brenke C, Krogias C, Scholz M, Harders A, Ermert H, Schmieder K (2007) Feasibility of contrast-enhanced sonography during resection of cerebral tumours: initial results of a prospective study. Ultrasound Med Biol 33(4):571–575. doi:10.1016/j.ultrasmedbio.2006.10.007
He W, Jiang XQ, Wang S, Zhang MZ, Zhao JZ, Liu HZ, Ma J, Xiang DY, Wang LS (2008) Intraoperative contrast-enhanced ultrasound for brain tumors. Clin Imaging 32(6):419–424. doi:10.1016/j.clinimag.2008.05.006
Holscher T, Ozgur B, Singel S, Wilkening WG, Mattrey RF, Sang H (2007) Intraoperative ultrasound using phase inversion harmonic imaging: first experiences. Neurosurgery 60(4 Suppl 2):382–386. doi:10.1227/01.neu.0000255379.87840.6e; discussion 386–387
Kanno H, Ozawa Y, Sakata K, Sato H, Tanabe Y, Shimizu N, Yamamoto I (2005) Intraoperative power Doppler ultrasonography with a contrast-enhancing agent for intracranial tumors. J Neurosurg 102(2):295–301. doi:10.3171/jns.2005.102.2.0295
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Prada, F., Del Bene, M., DiMeco, F. (2016). Contrast-Enhanced Ultrasound (CEUS) in Neurosurgery. In: Prada, F., Solbiati, L., Martegani, A., DiMeco, F. (eds) Intraoperative Ultrasound (IOUS) in Neurosurgery. Springer, Cham. https://doi.org/10.1007/978-3-319-25268-1_13
Download citation
DOI: https://doi.org/10.1007/978-3-319-25268-1_13
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-25266-7
Online ISBN: 978-3-319-25268-1
eBook Packages: MedicineMedicine (R0)