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Post-transcriptional Regulation of Cytokine Signaling During Inflammatory Responses

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Post-transcriptional Mechanisms in Endocrine Regulation

Abstract

Cytokines serve essential roles in cell to cell communication during development, maintenance of homeostasis, and responses to external stimuli. The expression of cytokines and the signals transmitted by cytokines to target cells need to be tightly regulated at several levels, including transcriptional and post-transcriptional levels. We briefly summarize the role of post-transcriptional mechanisms in coordinating the regulation of cytokine signaling during inflammatory responses, with an emphasis on AU-rich elements (AREs) and GU-rich elements (GREs). AREs and GREs work in concert to coordinate networks of cytokine signaling. The precise regulation of cytokine signaling is particularly important because its dysregulation can be a contributing factor for human diseases, including autoimmune diseases and cancer.

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  • 29 October 2020

    The original online version of this chapter was inadvertently published with part of last name of the author “Irina Vlasova-St. Louis” included along with the first name. The correct first and last name of this author is given below:

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Acknowledgments

This work was supported by National Institutes of Health grants AI057484 and AI072068 to P.R.B. We would like to thank Eric Collins, for critical reading and scientific editing of the manuscript. Our acknowledgements to University of Minnesota Supercomputing Institute for providing the access to Ingenuity Pathway Assistant.

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Authors and Affiliations

  1. Department of Medicine, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota, McGuire Translational Research Facility, 2001 6th Street SE, Office 3-500B, Minneapolis, MN, 55455, USA

    Irina Vlasova-St. Louis MD, PhD & Paul R. Bohjanen MD, PhD

  2. Department of Microbiology, University of Minnesota, Minneapolis, MN, 55455, USA

    Paul R. Bohjanen MD, PhD

Authors
  1. Irina Vlasova-St. Louis MD, PhD
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  2. Paul R. Bohjanen MD, PhD
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Correspondence to Irina Vlasova-St. Louis MD, PhD .

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Editors and Affiliations

  1. Departments of Biological Chemistry & Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI, USA

    K.M.J. Menon, PhD

  2. Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI, USA

    Aaron Goldstrohm, PhD

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Vlasova-St. Louis, I., Bohjanen, P.R. (2016). Post-transcriptional Regulation of Cytokine Signaling During Inflammatory Responses. In: Menon, PhD, K., Goldstrohm, PhD, A. (eds) Post-transcriptional Mechanisms in Endocrine Regulation. Springer, Cham. https://doi.org/10.1007/978-3-319-25124-0_3

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