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International Workshop on Machine Learning in Medical Imaging

MLMI 2015: Machine Learning in Medical Imaging pp 178–185Cite as

Group-Constrained Laplacian Eigenmaps: Longitudinal AD Biomarker Learning

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Part of the Lecture Notes in Computer Science book series (LNIP,volume 9352)

Abstract

Longitudinal modeling of biomarkers to assess a subject’s risk of developing Alzheimers disease (AD) or determine the current state in the disease trajectory has recently received increased attention.Here, a new method to estimate the time-to-conversion (TTC) of mild cognitive impaired (MCI) subjects to AD from a low-dimensional representation of the data is proposed. This is achieved via a combination of multilevel feature selection followed by a novel formulation of the Laplacian Eigenmaps manifold learning algorithm that allows the incorporation of group constraints.Feature selection is performed using Magnetic Resonance (MR) images that have been aligned at different detail levels to a template. The suggested group constraints are added to the construction of the neighborhood matrix which is used to calculate the graph Laplacian in the Laplacian Eigenmaps algorithm.The proposed formulation yields relevant improvements for the prediction of the TTC and for the three-way classification (control/MCI/AD) on the ADNI database.

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Authors and Affiliations

  1. Biomedical Image Analysis Group, Imperial College London, London, UK

    R. Guerrero, C. Ledig, A. Schmidt-Richberg & D. Rueckert

Authors
  1. R. Guerrero
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  2. C. Ledig
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  3. A. Schmidt-Richberg
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  4. D. Rueckert
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Corresponding author

Correspondence to R. Guerrero .

Editor information

Editors and Affiliations

  1. School of Computing and Information Technology, University of Wollongong, Wollongong, NSW, Australia

    Luping Zhou

  2. Radiology and BRIC, University of North Carolina, Chapel Hill, NC, USA

    Li Wang

  3. Biomedical Engineering, Shanghai Jiaotong University, Shanghai, China

    Dr. Qian Wang

  4. Computer Science, Nanjing University, Nanjing, China

    Prof. Yinghuan Shi

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Guerrero, R., Ledig, C., Schmidt-Richberg, A., Rueckert, D. (2015). Group-Constrained Laplacian Eigenmaps: Longitudinal AD Biomarker Learning. In: Zhou, L., Wang, L., Wang, Q., Shi, Y. (eds) Machine Learning in Medical Imaging. MLMI 2015. Lecture Notes in Computer Science(), vol 9352. Springer, Cham. https://doi.org/10.1007/978-3-319-24888-2_22

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  • DOI: https://doi.org/10.1007/978-3-319-24888-2_22

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-24887-5

  • Online ISBN: 978-3-319-24888-2

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