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Predicting Standard-Dose PET Image from Low-Dose PET and Multimodal MR Images Using Mapping-Based Sparse Representation

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Machine Learning in Medical Imaging (MLMI 2015)

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Abstract

Positron emission tomography (PET) has been widely used in clinical diagnosis of diseases or disorders. To reduce the risk of radiation exposure, we propose a mapping-based sparse representation (m-SR) framework for prediction of standard-dose PET image from its low-dose counterpart and corresponding multimodal magnetic resonance (MR) images. Compared with the conventional patch-based SR, our method uses a mapping strategy to ensure that the sparse coefficients estimated from the low-dose PET and multimodal MR images could be directly applied to the prediction of standard-dose PET images. An incremental refinement framework is also proposed to further improve the performance. Finally, a patch selection based dictionary construction method is used to speed up the prediction process. The proposed method has been validated on a real human brain dataset, showing that our method can work much better than the state-of-the-art method both qualitatively and quantitatively.

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Correspondence to Dinggang Shen .

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© 2015 Springer International Publishing Switzerland

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Wang, Y. et al. (2015). Predicting Standard-Dose PET Image from Low-Dose PET and Multimodal MR Images Using Mapping-Based Sparse Representation. In: Zhou, L., Wang, L., Wang, Q., Shi, Y. (eds) Machine Learning in Medical Imaging. MLMI 2015. Lecture Notes in Computer Science(), vol 9352. Springer, Cham. https://doi.org/10.1007/978-3-319-24888-2_16

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  • DOI: https://doi.org/10.1007/978-3-319-24888-2_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-24887-5

  • Online ISBN: 978-3-319-24888-2

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