Mechanisms of Arterial Stiffness

  • Bradley S. Fleenor
  • Adam J. Berrones
Part of the SpringerBriefs in Physiology book series (BRIEFSPHYSIOL)


Current understanding for the mechanisms contributing to arterial stiffness is limited. The field is rapidly growing, however, and the complex process of functional, structural and signaling pathways working together to stiffen arteries is becoming increasingly clear. As such, arterial dilation and constriction, extracellular matrix accumulation and stiffening of individual cells via specific signal transduction pathways inter-connect providing numerous targets for potential therapeutic intervention. Herein we highlight the mechanisms that are largely implicated in arterial stiffness, and those that may be emerging as important targets.


Artery function Smooth muscle Adventitia Endothelium Collagen Elastin Advanced glycation end-products 


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Bradley S. Fleenor
    • 1
  • Adam J. Berrones
    • 1
  1. 1.Department of Kinesiology and Health PromotionUniversity of KentuckyLexingtonUSA

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