Skip to main content

Cerebrovascular Complications of Sickle Cell Anemia

  • Chapter
  • First Online:
Medical and Surgical Complications of Sickle Cell Anemia
  • 1280 Accesses

Abstract

A variety of neurological complications occur in patients with sickle cell anemia.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Further Reading

  • Adams R, McKie V, Nichols F, et al. The use of transcranial ultrasonography to predict stroke in sickle cell disease. N Engl J Med. 1992a;326:605–10.

    Article  CAS  PubMed  Google Scholar 

  • Adams RJ, Nichols FT, Figueroa R, et al. Transcranial Doppler correlation with cerebral angiography in sickle cell disease. Stroke. 1992b;23:1073.

    Article  CAS  PubMed  Google Scholar 

  • Adams RJ, McKie VC, Hsu L, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med. 1998;339:5.

    Article  CAS  PubMed  Google Scholar 

  • Aygun B, McMurray MA, Schultz WH, et al. Chronic transfusion practice for children with sickle cell anaemia and stroke. Br J Haematol. 2009;145:524.

    Article  PubMed  Google Scholar 

  • DeBaun MR, Sarnaik SA, Rodeghier MJ, et al. Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure. Blood. 2012;119:3684.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • DeBaun MR, Gordon M, McKinstry RC, et al. Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia. N Engl J Med. 2014;371:699.

    Article  PubMed  PubMed Central  Google Scholar 

  • Helton KJ, Wang WC, Wynn LW, et al. The effect of hydroxyurea on vasculopathy in a child with sickle cell disease. AJNR Am J Neuroradiol. 2002;23:1692–6.

    PubMed  Google Scholar 

  • Jordan LC, Casella JF, DeBaun MR. Prospects for primary stroke prevention in children with sickle cell anaemia. Br J Haematol. 2012;157:14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kwiatkowski JL, Zimmerman RA, Pollock AN, et al. Silent infarcts in young children with sickle cell disease. Br J Haematol. 2009;146:300.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lefèvre N, Dufour D, Gulbis B, et al. Use of hydroxyurea in prevention of stroke in children with sickle cell disease. Blood. 2008;111:963.

    Article  PubMed  Google Scholar 

  • Ohene-Frempong K, Weiner SJ, Sleeper LA, et al. Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood. 1998;91:288.

    CAS  PubMed  Google Scholar 

  • Pegelow CH, Wang W, Granger S, et al. Silent infarcts in children with sickle cell anemia and abnormal cerebral artery velocity. Arch Neurol. 2001;58:2017–21.

    Article  CAS  PubMed  Google Scholar 

  • Powars DR. Management of cerebral vasculopathy in children with sickle cell anaemia. Br J Haematol. 2000;108:666.

    Article  CAS  PubMed  Google Scholar 

  • Quinn CT, McKinstry RC, Dowling MM, et al. Acute silent cerebral ischemic events in children with sickle cell anemia. JAMA Neurol. 2013;70:58.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schatz J, Brown RT, Pascual JM, et al. Poor school and cognitive functioning with silent cerebral infarcts and sickle cell disease. Neurology. 2001;56:1109–11.

    Article  CAS  PubMed  Google Scholar 

  • Scothorn DJ, Price C, Schwartz D, et al. Risk of recurrent stroke in children with sickle cell disease receiving blood transfusion therapy for at least five years after initial stroke. J Pediatr. 2002;140:348–54.

    Article  PubMed  Google Scholar 

  • Verduzco LA, Nathan DG. Sickle cell disease and stroke. Blood. 2009;114:5117.

    Article  CAS  PubMed  Google Scholar 

  • Verlhac S, Bernaudin F, Tortrat D, et al. Detection of cerebrovascular disease in patients with sickle cell disease using transcranial Doppler sonography: correlation with MRI, MRA and conventional angiography. Pediatr Radiol. 1995;25 Suppl 1:S14.

    PubMed  Google Scholar 

  • Walters MC, Storb R, Patience M, et al. Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report. Multicenter investigation of bone marrow transplantation for sickle cell disease. Blood. 2000;95:1918–24.

    CAS  PubMed  Google Scholar 

  • Ware RE, Zimmerman SA, Schultz WH. Hydroxyurea as an alternative to blood transfusion for the prevention of recurrent stroke in children with sickle cell disease. Blood. 1999;94:3022–6.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Al-Salem, A. (2016). Cerebrovascular Complications of Sickle Cell Anemia. In: Medical and Surgical Complications of Sickle Cell Anemia. Springer, Cham. https://doi.org/10.1007/978-3-319-24762-5_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-24762-5_15

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-24760-1

  • Online ISBN: 978-3-319-24762-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics