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Regulation of Membrane Na+-K+ ATPase pp 323–338Cite as

Redox Regulation of the Na+-K+ ATPase in the Cardiovascular System

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Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 15))

Abstract

The Na+-K+ ATPase is called “the oldest pump” as it has been the first of P-Type ATPases family to be discovered. This α/β heterodimeric molecule has an essential role in membrane transport of ions and organic molecules, and in cardiac myocytes, plays a key role in excitation–contraction coupling. Due to dynamic changes in the complex in vivo milieu, the pump function is tightly regulated in order to adapt to changing needs. Accumulating evidence has formed a consensus view that pump regulation is mediated by changes in phosphorylation of the FXYD1 protein that associates with the pump. However, this view is challenged by the lack of putative phosphorylation sites on the whole family of FXYD proteins that are expressed in tissue-specific manner. Moreover, the proposed functional effects of the phosphorylation, e.g. via β adrenergic signalling, are at odds with the role of the pump in clinical conditions like heart failure, and the clinical efficacy of drugs that block β1 adrenergic signalling. Regulation of the pump function via oxidative post-translational modification has emerged as an alternative with glutathionylation of β1 pump subunit and FXYD1 playing a dynamic regulatory role via receptor-coupled signalling in a variety of clinical conditions. In this chapter we briefly review structure and function of the Na+-K+ pump, and discuss in detail its regulation by redox pathways in the heart and critical regulatory role of FXYD1 proteins. We present the emerging role of redox regulation in the vasculature, where such signalling can have broad effects on cellular processes including vascular proliferation.

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Authors and Affiliations

  1. Oxidative Signalling Group, Kolling Institute, University of Sydney, St Leonards, NSW, 2065, Australia

    Keyvan Karimi Galougahi & Gemma A. Figtree

  2. Department of Cardiology, Royal North Shore Hospital, Sydney, NSW, Australia

    Keyvan Karimi Galougahi & Gemma A. Figtree

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  1. Keyvan Karimi Galougahi
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  2. Gemma A. Figtree
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Correspondence to Gemma A. Figtree .

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Editors and Affiliations

  1. Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. University of Manitoba, Institute of Cardiovascular Science St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Naranjan S Dhalla

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Karimi Galougahi, K., Figtree, G.A. (2016). Redox Regulation of the Na+-K+ ATPase in the Cardiovascular System. In: Chakraborti, S., Dhalla, N. (eds) Regulation of Membrane Na+-K+ ATPase. Advances in Biochemistry in Health and Disease, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-319-24750-2_19

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