Abstract
Although the cerebellum participates in many different functions, its coordinating role in learning and execution of movements remains its most visible aspect to our behavior. Multiple pathways convey information from the body to the cerebellum. These spinal pathways can be divided in systems that, either directly or indirectly, enter the cerebellar cortex to terminate as mossy fibers and in pathways that reach the cerebellum by way of the inferior olive and as a consequence will terminate as climbing fibers. Cerebellar processing is also mediated to the spinal cord by a multitude of routes. Corticospinal, rubrospinal, tectospinal, vestibulospinal and reticulospinal tracts may all, at least to some extent, be controlled by cerebellar output.
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References
Apps R, Hawkes R (2009) Cerebellar cortical organization: a one-map hypothesis. Nat Rev Neurosci 10(9):670–681
Arshavsky YI, Gelfand IM, Orlovsky GN (1986) Cerebellum and rhythmical movements, vol 13, Studies of brain function. Springer, Berlin
Azim E, Jiang J, Alstermark B, Jessell TM (2014) Skilled reaching relies on a V2a propriospinal internal copy circuit. Nature 508(7496):357–363. doi:10.1038/nature13021
Bagnall MW, Zingg B, Sakatos A, Moghadam SH, Zeilhofer HU, du Lac S (2009) Glycinergic projection neurons of the cerebellum. J Neurosci 29(32):10104–10110
Barmack NH (2003) Central vestibular system: vestibular nuclei and posterior cerebellum. Brain Res Bull 60(5-6):511–541
Cicirata F, Angaut P, Serapide MF, Panto MR, Nicotra G (1992) Multiple representation in the nucleus lateralis of the cerebellum: an electrophysiologic study in the rat. Exp Brain Res Exp Hirnforsch Exp Cereb 89(2):352–362
Esposito MS, Capelli P, Arber S (2014) Brainstem nucleus MdV mediates skilled forelimb motor tasks. Nature 508(7496):351–356. doi:10.1038/nature13023
Fields H (2004) State-dependent opioid control of pain. Nat Rev 5(7):565–575
Flavell CR, Cerminara NL, Apps R, Lumb BM (2014) Spino-olivary projections in the rat are anatomically separate from postsynaptic dorsal column projections. J Comp Neurol 522(9):2179–2190. doi:10.1002/cne.23527
Fukushima K, van der Hoeff-van Halen R, Peterson BW (1978) Direct excitation of neck motoneurons by interstitiospinal fibers. Exp Brain Res 33(3-4):565–581
Holstege G, Cowie RJ (1989) Projections from the rostral mesencephalic reticular formation to the spinal cord. An HRP and autoradiographical tracing study in the cat. Exp Brain Res 75(2):265–279
Kitamura T, Yamada J (1989) Spinocerebellar tract neurons with axons passing through the inferior or superior cerebellar peduncles. A retrograde horseradish peroxidase study in rats. Brain Behav Evol 34(3):133–142
Lawrence DG, Kuypers HG (1968) The functional organization of the motor system in the monkey. II. The effects of lesions of the descending brain-stem pathways. Brain 91(1):15–36
Matsushita M, Yaginuma H (1989) Spinocerebellar projections from spinal border cells in the cat as studied by anterograde transport of wheat germ agglutinin-horseradish peroxidase. J Comp Neurol 288(1):19–38. doi:10.1002/cne.902880103
Matsushita M, Gao X, Yaginuma H (1995) Spinovestibular projections in the rat, with particular reference to projections from the central cervical nucleus to the lateral vestibular nucleus. J Comp Neurol 361(2):334–334. doi:10.1002/cne.903610210
Nisimaru N (2004) Cardiovascular modules in the cerebellum. Jpn J Physiol 54(5):431–448
Onodera S, Hicks TP (2009) A comparative neuroanatomical study of the red nucleus of the cat, macaque and human. PLoS One 4(8):e6623
Oscarsson O, Sjolund B (1977) The ventral spino-olivocerebellar system in the cat. I. Identification of five paths and their termination in the cerebellar anterior lobe. Exp Brain Res 28(5):469–486
Pivetta C, Esposito MS, Sigrist M, Arber S (2014) Motor-circuit communication matrix from spinal cord to brainstem neurons revealed by developmental origin. Cell 156(3):537–548. doi:10.1016/j.cell.2013.12.014
Proville RD, Spolidoro M, Guyon N, Dugue GP, Selimi F, Isope P, Popa D, Lena C (2014) Cerebellum involvement in cortical sensorimotor circuits for the control of voluntary movements. Nat Neurosci 17(9):1233–1239. doi:10.1038/nn.3773
Quy PN, Fujita H, Sakamoto Y, Na J, Sugihara I (2011) Projection patterns of single mossy fiber axons originating from the dorsal column nuclei mapped on the aldolase C compartments in the rat cerebellar cortex. J Comp Neurol 519(5):874–899
Ruigrok TJ (2011) Ins and outs of cerebellar modules. Cerebellum (Lond Engl) 10(3):464–474
Ruigrok TJH (2013) Cerebellar influences on descending spinal motor systems. In: Manto M, Gruol JD, Schmahmann N, Koibuchi N, Rossi F (eds) Handbook of the cerebellum and cerebellum disorders. Springer, Dordrecht, pp 497–528
Ruigrok TJ, Pijpers A, Goedknegt-Sabel E, Coulon P (2008) Multiple cerebellar zones are involved in the control of individual muscles: a retrograde transneuronal tracing study with rabies virus in the rat. Eur J Neurosci 28(1):181–200
Tolbert DL, Bantli H, Hames EG, Ebner TJ, McMullen TA, Bloedel JR (1980) A demonstration of the dentato-reticulospinal projection in the cat. Neuroscience 5(8):1479–1488
Udo M, Oda Y, Tanaka K, Horikawa J (1976) Cerebellar control of locomotion investigated in cats: discharges from Deiters’ neurones, EMG and limb movements during local cooling of the cerebellar cortex. Prog Brain Res 44:445–459. doi:10.1016/S0079-6123(08)60751-7
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Ruigrok, T.J.H. (2016). Spinocerebellar and Cerebellospinal Pathways. In: Gruol, D., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-24551-5_9
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