Abstract
Long-term depression (LTD) at parallel fiber (PF) -Purkinje cell (PC) synapses is thought to play an important role in cerebellar motor learning. LTD is mediated by postsynaptic AMPA receptor endocytosis. Concurrent activation of PF and climbing fibers generates specific temporal and spatial Ca2+ dynamics in PC dendritic spines leading to activation of signaling cascade required for LTD.
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Acknowledgements
This work was supported by the Grant-in-Aid from the MEXT of Japan (15H05772, 23240053) and the CREST from the JST.
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Kohda, K., Kakegawa, W., Yuzaki, M. (2016). Long-Term Depression at Parallel Fiber-Purkinje Cell Synapses. In: Gruol, D., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-24551-5_45
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DOI: https://doi.org/10.1007/978-3-319-24551-5_45
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