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A Risk-Adapted Approach to Breast Radiation Using Targeted Intraoperative Radiotherapy (TARGIT)

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Short Course Breast Radiotherapy

Abstract

Whole-organ detailed three-dimensional pathological analysis of mastectomy specimens vis-à-vis the results of breast-conserving surgery trials demonstrates a remarkable phenomenon: in addition to the main tumor, the mastectomy specimen reveals often multiple foci of cancer distributed widely in the breast volume. This is in contrast with the location of a local recurrence, which mostly occurs in the area around the original tumor – thus, it makes sense to focus radiation only around the original tumor. Based on this insight, the targeted intraoperative radiotherapy technique and the device to deliver it were developed in the late 1990s, the first case treated at the Middlesex Hospital, University College London, UK, on 2 July 1998. Pilot studies confirmed feasibility and safety, and in March 2000, the TARGIT-A randomized trial was launched.

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Correspondence to Jayant S. Vaidya MBBS MS DNB FRCS PhD .

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Vaidya, J.S. et al. (2016). A Risk-Adapted Approach to Breast Radiation Using Targeted Intraoperative Radiotherapy (TARGIT). In: Arthur, D., Vicini, F., Wazer, D., Khan, A. (eds) Short Course Breast Radiotherapy. Springer, Cham. https://doi.org/10.1007/978-3-319-24388-7_21

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  • DOI: https://doi.org/10.1007/978-3-319-24388-7_21

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