CREB-Mediated Memory Enhancement

  • Anne TanenhausEmail author
  • Jiabin Zhang
  • Jerry C. P. Yin


CREB-responsive transcription is a conserved, important mechanism employed during memory formation. In both Drosophila and mice, overexpression of the activator isoform can enhance this process. However, in both systems, some conflicting data exists, providing a lingering doubt about its universality. In this review, we consider how molecular, cellular and systems parameters affect the fly dCREB2 gene during memory formation. This multi-level analysis provides plausible explanations for some of the discrepant data that exists in the fly system, and perhaps can inform mouse behavioral analysis as well.


CREB Long-term memory Memory enhancement Intrinsic excitability Synaptic plasticity Drosophila cAMP signaling Transcription Systems neuroscience 


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Anne Tanenhaus
    • 1
    Email author
  • Jiabin Zhang
    • 2
  • Jerry C. P. Yin
    • 3
  1. 1.Department of EmbryologyCarnegie Institution for ScienceBaltimoreUSA
  2. 2.Department of Molecular Pharmacology and Experimental TherapeuticsMayo ClinicRochesterUSA
  3. 3.Laboratory of GeneticsUniversity of Wisconsin, MadisonMadisonUSA

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