Reconsolidation and the Dynamic Nature of Memory
Research on the reconsolidation effect was greatly revitalized by the highly analytic demonstration of memory reconsolidation (Nader et al. 2000) in a well-defined behavioral protocol (auditory fear conditioning in the rat). Since this study, reconsolidation has been demonstrated in hundreds of studies over a range of species, tasks, and amnesic agents. Evidence for reconsolidation does not come solely from the behavioral level of analysis. Cellular and molecular correlates of reconsolidation have also been found. In this review I will first define the evidence on which reconsolidation is concluded to exist. I will then discuss some of the conceptual issues facing the field in determining when reconsolidation does and does not occur. Lastly I will explain the clinical implications of this effect.
KeywordsMemory stabilization Memory destabilization Memory re-stabilization Memory maintenance
K.N. was supported by the Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, Canadian Foundation for Innovation, The Volkswagen, Alfred P. Sloan and EJL Karim Nader is a James McGill Chair.
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