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Lung Cancer in Never Smokers

  • Gabriel Alberto Rivera
  • Heather WakeleeEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 893)

Abstract

Lung cancer is predominantly associated with cigarette smoking; however, a substantial minority of patients with the disease have never smoked. In the US it is estimated there are 17,000–26,000 annual deaths from lung cancer in never smokers, which as a separate entity would be the seventh leading cause of cancer mortality. Controversy surrounds the question of whether or not the incidence of lung cancer in never-smokers is increasing, with more data to support this observation in Asia. There are several factors associated with an increased risk of developing lung cancer in never smokers including second hand smoke, indoor air pollution, occupational exposures, and genetic susceptibility among others. Adenocarcinoma is the most common histology of lung cancer in never smokers and in comparison to lung cancer in smokers appears less complex with a higher likelihood to have targetable driver mutations.

Keywords

Non-smoker lung cancer Lung cancer in nonsmokers 

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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Stanford UniversityStanfordUSA

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