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Current State of Metal-Based Drugs for the Efficient Therapy of Lung Cancers and Lung Metastases

  • Bernhard BiersackEmail author
  • Rainer Schobert
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 893)

Abstract

Lung cancer is the second most common cancer in both men and women and thus a leading cause of cancer-related deaths worldwide. New efficient treatments especially for its advanced stages and metastases are desperately needed, particularly with regard to overcoming the resistance which thwarts the efficacy of most clinically established drugs such as the platinum complexes. Glimpses of hope are new metal-based drugs that have emerged over the past decade which displayed efficacy in patients with platinum-resistant tumors and metastases. This chapter provides an overview of the latest developments of such metal-based drugs against lung cancer.

Keywords

Platinum complexes Ruthenium complexes Gadolinium Ferrocene derivatives Anticancer agents Lung cancer Lung metastasis Multi-drug resistance Tumor targeting 

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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Organic Chemistry LaboratoryUniversity of BayreuthBayreuthGermany

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