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Endothelial Keratoplasty

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Corneal Transplantation

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Abstract

Full-thickness corneal transplant was for many years the only surgical option for corneal endothelial diseases. With the advantages of better visual potential, shorter recovery times, and lower rejection risk, endothelial keratoplasty (EK) has now superseded penetrating keratoplasty (PK) for these conditions. This revolutionary change was initiated by the insight of Gerrit Melles that partial-thickness grafts could stick to the back of the cornea without sutures. Progressive surgical refinement and advances in instrumentation by many surgeons have led to widespread adoption. Currently, Descemet’s stripping endothelial keratoplasty (DSEK/DSAEK) is the most popular surgical procedure for corneal endothelial dysfunction. Descemet’s membrane endothelial keratoplasty (DMEK) has emerged as an alternative to DSEK offering improved vision, shorter recovery time, and reduced rates of immunologic graft rejections. Compared to DSEK, DMEK selectively replaces bare endothelium and Descemet’s membrane without a stromal scaffold. This chapter focuses on the evolution of EK, techniques, outcomes, and complications.

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Authors and Affiliations

  1. Price Vision Group, Indianapolis, IN, USA

    Ovette F. Villavicencio MD, PhD & Francis W. Price Jr. MD

  2. Cornea Research Foundation of America, Indianapolis, IN, USA

    Marianne O. Price PhD

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  1. Ovette F. Villavicencio MD, PhD
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  2. Marianne O. Price PhD
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  3. Francis W. Price Jr. MD
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Correspondence to Marianne O. Price PhD .

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  1. Aarhus, Denmark

    Jesper Hjortdal

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Villavicencio, O.F., Price, M.O., Price, F.W. (2016). Endothelial Keratoplasty. In: Hjortdal, J. (eds) Corneal Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-24052-7_4

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