Abstract
Infertility is a worldwide growing issue, and female factors account for about 30 % of the total cases of infertility. The majority of couples affected by infertility undergo in vitro fertilization (IVF) protocols following women hormonal hyperstimulation cycles to obtain mature oocytes to fertilize in vitro. Nowadays, the oocyte/embryo quality is mainly assessed by morphokinetic parameters even if these approaches have low objective prediction value. The rate of live newborns after IVF is relatively low, ranging from about 30 % in younger women to 10 % in the older ones. Aging, in fact, is a well-known critical factor for the success of IVF protocols. As a consequence, a primary goal in older women is to increase the pregnancy rate, with a crucial point represented by the selection of the oocytes to fertilize in vitro and transfer in women.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Johnson MH (2007) Ovarian function in the adult. In: Johson MH, Everitt BJ (eds) Essential reproduction, 6th edn. Blackwell Scientific Ltd, Oxford, pp 82–91
Albertini DF, Combelles CM, Benecchi E, Carabatsos MJ (2001) Cellular basis for paracrine regulation of ovarian follicle development. Reproduction 121:647–653
Eppig JJ, Pendola FL, Wigglesworth K, Pendola JK (2005) Mouse oocytes regulate metabolic cooperativity between garnulosa cells and oocytes: amino acid transport. Biol Reprod 73:351–357
Gilchrist RB, Lane M, Thompson JG (2008) Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality. Hum Reprod Update 14:159–177
Sanchez F, Smitz J (1822) Molecular control of oogenesis. Biochim Biophys Acta 2012:1896–1912
Fragouli E, Lalioti MD, Wells D (2014) The transcriptome of follicular cells: biological insights and clinical implications for the treatment of infertility. Hum Reprod Update 20:1–11
Chronowska E (2014) High-throughput analysis of ovarian granulosa cell transcriptome. Biomed Res Int 2014:213570
Fragouli E, Wells D, Iager AE, Kayisli UA, Patrizio P (2012) Alteration of gene expression in human cumulus cells as a potential indicator of oocyte aneuploidy. Hum Reprod 27:2559–2568
Feuerstein P, Puard V, Chevalier C, Teusan R, Cadoret V, Guerif F, Houlgatte R, Royere D (2012) Genomic assessment of human cumulus cell marker genes as predictors of oocyte developmental competence: impact of various experimental factors. PLoS One 7:e40449
Gatta V, Tatone C, Ciriminna R, Vento M, Franchi S, d’Aurora M, Sperduti S, Cela V, Borzì P, Palermo R, Stuppia L, Artini PG (2013) Gene expression profiles of cumulus cells obtained from women treated with recombinant human luteinizing hormone + recombinant human follicle-stimulating hormone or highly purified human menopausal gonadotropin versus recombinant human follicle-stimulating hormone alone. Fertil Steril 99:2000–2008
Borgbo T, Povlsen BB, Andersen CY, Borup R, Humaidan P, Grøndahl ML (2013) Comparison of gene expression profiles in granulosa and cumulus cells after ovulation induction with either human chorionic gonadotropin or a gonadotropin-releasing hormone agonist trigger. Fertil Steril 100:994–1001
Haouzi D, Assou S, Monzo C, Vincens C, Dechaud H, Hamamah S (2012) Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome. Hum Reprod 27:89–96
Schmidt J, Weijdegård B, Mikkelsen AL, Lindenberg S, Nilsson L, Brännström M (2014) Differential expression of inflammation-related genes in the ovarian stroma and granulosa cells of PCOS women. Mol Hum Reprod 20:49–58
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 International Society of Gynecological Endocrinology
About this chapter
Cite this chapter
Artini, P.G. (2016). Gene Expression in Cumulus Cells and Oocyte Quality. In: Genazzani, A., Tarlatzis, B. (eds) Frontiers in Gynecological Endocrinology. ISGE Series. Springer, Cham. https://doi.org/10.1007/978-3-319-23865-4_5
Download citation
DOI: https://doi.org/10.1007/978-3-319-23865-4_5
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-23864-7
Online ISBN: 978-3-319-23865-4
eBook Packages: MedicineMedicine (R0)