Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis and Erythema Exsudativum Multiforme
In the past, definitions and even the name giving of erythema exsudativum multiforme, Stevens–Johnson syndrome and toxic epidermal necrolysis have been confusing. However, after a consensus classification, which separates erythema exsudativum multiforme from Stevens–Johnson syndrome and toxic epidermal necrolysis, it is now generally accepted that Stevens–Johnson syndrome and toxic epidermal necrolysis are variants within a continuous spectrum of severe, potentially fatal, mucocutaneous adverse drug reactions, whereas erythema exsudativum multiforme is a distinct, generally more mild entity with different clinical signs, mainly precipitated by infections, e.g. herpes simplex virus.
KeywordsKeratinocyte Epidermis Skin Mucosae Apoptosis Epidermal necrosis Adverse drug reactions Stevens–Johnson syndrome Toxic epidermal necrolysis Erythema exsudativum multiforme
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