Drug-Induced Pemphigoid and Linear IgA Disease
Drug-induced pemphigoid and drug-induced linear IgA disease can be difficult to differentiate from bullous pemphigoid (BP), mucous membrane pemphigoid (MMP), and linear IgA disease (LAD) because of only minor differences in clinical, histopathologic, and immunopathologic features. However, differentiation can be of major importance because of a different approach, treatment, and outcome. Diagnosis is mainly based on the time relation between start of the suspected drug(s) and onset of the lesions. Drug-induced BP and drug-induced LAD tend to be self-limiting after withdrawal of the culprit drug.
KeywordsAutoimmune disease Vesiculobullous disease Adverse drug reaction Drug induced Drug triggered Bullous pemphigoid Linear IgA disease Diuretics Vancomycin
- 3.Bastuji-Garin S, Joly P, Picard-Dahan C, Bernard P, Vaillant L, Pauwels C, Salagnac V, Lok C, Roujeau JC. Drugs associated with bullous pemphigoid. A case-control study. Arch Dermatol. 1996;132(3):272–6.Google Scholar
- 5.Chanal J, Ingen-Housz-Oro S, Ortonne N, Duong TA, Thomas M, Valeyrie-Allanore L, Lebrun-Vignes B, André C, Roujeau JC, Chosidow O, Wolkenstein P. Linear IgA bullous dermatosis: comparison between the drug-induced and spontaneous forms. Br J Dermatol. 2013;169(5):1041–8.Google Scholar