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Bullous Systemic Lupus Erythematosus

  • Marcel F. JonkmanEmail author
Chapter

Abstract

Bullous systemic lupus erythematosus (BSLE) is a confusing concept. With BSLE type I, an autoimmune response to type VII collagen is mend, leading to epidermolysis bullosa acquisita in patients with systemic lupus erythematosus (SLE). If no autoimmune reaction to type VII collagen is demonstrable, BSLE type II is mend, which consists of an acute generalized hemorrhagic vesiculobullous eruption in SLE. Vesicular eruptions may also occur rarely in subacute cutaneous lupus erythematosus due to severe inflammatory reaction with subepidermal clefting, which in extreme cases may resemble erythema multiforme (Rowell syndrome) or toxic epidermal necrolysis.

Keywords

Lupus erythematosus Epidermolysis bullosa acquisita Type VII collagen 

References

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Additional Reading

  1. Vassileva S. Bullous systemic lupus erythematosus. Clin Dermatol. 2004;22:129–38.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of DermatologyCenter for Blistering Diseases, University Medical Center Groningen, University of GroningenGroningenthe Netherlands

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