Drug-Induced Pemphigus

  • Sylvia H. KardaunEmail author
  • Laura de Sena Nogueira Maehara


Drug-induced pemphigus can be induced or triggered by drugs, most often penicillamine and other thiol-associated drugs. The time from first intake of the drug to onset of the reaction is often relatively long compared to other cutaneous adverse drug reactions. Clinically, it can present as pemphigus foliaceus (most often), pemphigus erythematosus, pemphigus herpetiformis, or pemphigus vulgaris. Opposing to idiopathic pemphigus, pruritus, a prodromal stage, and absence of mucosal involvement are frequent, while laboratory findings are similar. The pathogenesis is not completely known, but probably includes endogenous and exogenous factors. Withdrawal of the culprit drug is mandatory, although the disease may not subside if caused by nonthiol drugs.


Vesiculobullous disease Autoimmune disease Adverse drug reaction Pemphigus Drug induced Drug triggered Penicillamine Thiol-associated drugs 


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On the Web

  1. Litt’s Drug Eruption & Reaction Database.

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Sylvia H. Kardaun
    • 1
    Email author
  • Laura de Sena Nogueira Maehara
    • 1
    • 2
  1. 1.Department of DermatologyCenter for Blistering Diseases, University Medical Center Groningen, University of GroningenGroningenthe Netherlands
  2. 2.Department of DermatologyPaulista School of Medicine, Federal University of São PauloSão PauloBrazil

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