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The Role of Infectious Agents in the Pathogenesis of Autoimmune Diseases

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Abstract

Ophthalmologists treating patients with ocular inflammatory diseases are faced with a number of disorders of unknown etiology including, Behçet disease, sarcoidosis, Vogt-Koyanagi-Harada disease, HLA-B27-associated anterior uveitis, Fuchs uveitis syndrome, serpiginous and serpiginoid choroiditis, birdshot chorioretinopathy, and white dot syndromes. Recent data have shown various clues to the role of environmental factors, most importantly, bacteria, viruses, and other pathogens as well as vaccines in the pathogenesis of immune-mediated inflammatory disorders in general and immune-mediated uveitis in particular. Therefore, infectious triggers are increasingly recognized in the etiopathogenesis of various uveitis entities in genetically susceptible individuals. In this chapter we review the role of environmental factors, especially microorganisms, in the pathogenesis of different uveitis entities.

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Authors and Affiliations

  1. Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    Merih Oray MD & Ilknur Tugal-Tutkun MD

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  1. Merih Oray MD
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Correspondence to Ilknur Tugal-Tutkun MD .

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  1. Singapore National Eye Center, Singapore, Singapore

    Soon-Phaik Chee

  2. Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, Monastir, Tunisia

    Moncef Khairallah

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Oray, M., Tugal-Tutkun, I. (2017). The Role of Infectious Agents in the Pathogenesis of Autoimmune Diseases. In: Chee, SP., Khairallah, M. (eds) Emerging Infectious Uveitis. Springer, Cham. https://doi.org/10.1007/978-3-319-23416-8_2

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