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The Psychobiology of Attachment and the Aetiology of Disease

  • Tara KiddEmail author
Chapter

Abstract

The purpose of this chapter is to examine whether adult attachment insecurity confers a risk to physical health by examining the physiological components of the stress experience. It will focus primarily on the association between attachment and physiological stress responses as one potential mechanism that may explain “why” individual differences in regulatory strategies may be implicated in aetiology of disease. We begin by providing a brief overview of stress and health, then describe the impact of attachment processes on stress response, integrate these findings into the broader context of the stress literature, and end by mapping out future directions for contributing research.

Keywords

Cortisol Response Allostatic Load Attachment Anxiety Cortisol Awakening Response Cortisol Reactivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Beck LA, Pietromonaco PR, DeBuse CJ, Powers SI, Sayer AG (2013) Spouses’ attachment pairings predict neuroendocrine, behavioral, and psychological responses to marital conflict. J Pers Soc Psychology 105(3):388–424CrossRefGoogle Scholar
  2. Biglioli P, Cannata A, Alamanni F, Naliato M, Porqueddu M, Zanobini M, Parolari A (2003) Biological effects of off-pump vs. on-pump coronary artery surgery: focus on inflammation, hemostasis and oxidative stress. Eur J Cardiothorac Surg 24(2):260–269PubMedCrossRefGoogle Scholar
  3. Bilbo SD, Schwarz JM (2012) The immune system and developmental programming of brain and behavior. Front Neuroendocrinol 33(3):267–286PubMedCentralPubMedCrossRefGoogle Scholar
  4. Blascovich J, Tomaka J (1996) The biopsychosocial model of arousal regulation. Adv Exp Soc Psychol 28:1–51CrossRefGoogle Scholar
  5. Bowlby J (1969) Attachment and loss, vol. I. Attachment. Basic Books, New YorkGoogle Scholar
  6. Bowlby J (2005) A secure base: clinical applications of attachment theory. Taylor & Francis, New YorkGoogle Scholar
  7. Brooks KP, Robles TF, Schetter CD (2011) Adult attachment and cortisol responses to discussions with a romantic partner. Pers Relat 18(2):302–320CrossRefGoogle Scholar
  8. Carpenter EM, Kirkpatrick LA (1996) Attachment style and presence of a romantic partner as moderators of psychophysiological responses to a stressful laboratory situation. Pers Relat 3(4):351–367CrossRefGoogle Scholar
  9. Carpenter LL, Tyrka AR, Ross NS, Khoury L, Anderson GM, Price LH (2009) Effect of childhood emotional abuse and age on cortisol responsivity in adulthood. Biol Psychiatry 66(1):69–75PubMedCentralPubMedCrossRefGoogle Scholar
  10. Chida Y, Hamer M (2008) Chronic psychosocial factors and acute physiological responses to laboratory-induced stress in healthy populations: a quantitative review of 30 years of investigations. Psychol Bull 134(6):829PubMedCrossRefGoogle Scholar
  11. Chorpita BF, Barlow DH (1998) The development of anxiety: the role of control in the early environment. Psychol Bull 124(1):3PubMedCrossRefGoogle Scholar
  12. Christensen A, Heavey CL (1990) Gender and social structure in the demand/withdraw pattern of marital conflict. J Pers Soc Psychol 59(1):73PubMedCrossRefGoogle Scholar
  13. Ciechanowski P, Russo J, Katon W, Von Korff M, Ludman E, Lin E, Bush T (2004) Influence of patient attachment style on self-care and outcomes in diabetes. Psychosom Med 66(5):720–728PubMedCrossRefGoogle Scholar
  14. Cohen S, Janicki-Deverts D, Doyle WJ, Miller GE, Frank E, Rabin BS, Turner RB (2012) Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci 109(16):5995–5999PubMedCentralPubMedCrossRefGoogle Scholar
  15. Damjanovic AK, Yang Y, Glaser R, Kiecolt-Glaser JK, Nguyen H, Laskowski B, Weng NP (2007) Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer’s disease patients. J Immunol 179(6):4249–4254PubMedCentralPubMedCrossRefGoogle Scholar
  16. Davis D, Shaver PR, Vernon ML (2003) Physical, emotional, and behavioral reactions to breaking up: The roles of gender, age, emotional involvement, and attachment style. Pers Soc Psychol Bull 29(7):871–884PubMedCrossRefGoogle Scholar
  17. Denson TF, Spanovic M, Miller N (2009) Cognitive appraisals and emotions predict cortisol and immune responses: a meta-analysis of acute laboratory social stressors and emotion inductions. Psychol Bull 135(6):823PubMedCrossRefGoogle Scholar
  18. Dewitte M, Houwer J, Buysse A, Koster EH (2008) Proximity seeking in adult attachment: examining the role of automatic approach–avoidance tendencies. Br J Soc Psychol 47(4):557–573PubMedCrossRefGoogle Scholar
  19. Dewitte M, De Houwer J, Goubert L, Buysse A (2010) A multi-modal approach to the study of attachment-related distress. Biol Psychol 85(1):149–162PubMedCrossRefGoogle Scholar
  20. Diamond LM (2001) Contributions of psychophysiology to research on adult attachment: review and recommendations. Pers Soc Psychol Rev 5(4):276–295CrossRefGoogle Scholar
  21. Diamond LM, Hicks AM, Otter-Henderson KD (2008) Every time you go away: changes in affect, behavior, and physiology associated with travel-related separations from romantic partners. J Pers Soc Psychol 95(2):385PubMedCrossRefGoogle Scholar
  22. Dickerson SS, Kemeny ME (2004) Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol Bull 130(3):355PubMedCrossRefGoogle Scholar
  23. Ditzen B, Schmidt S, Strauss B, Nater UM, Ehlert U, Heinrichs M (2008) Adult attachment and social support interact to reduce psychological but not cortisol responses to stress. J Psychosom Res 64(5):479–486PubMedCrossRefGoogle Scholar
  24. Emerging Risk Factors Collaboration (2010) C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet 375(9709):132CrossRefGoogle Scholar
  25. Ershler WB, Keller ET (2000) Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med 51(1):245–270PubMedCrossRefGoogle Scholar
  26. Fagundes CP, Jaremka LM, Glaser R, Alfano CM, Povoski SP, Lipari AM, Kiecolt-Glaser JK (2014) Attachment anxiety is related to Epstein–Barr virus latency. Brain Behav Immun 41:232–238PubMedCentralPubMedCrossRefGoogle Scholar
  27. Feeney JA (1995) Adult attachment, coping style and health locus of control as predictors of health behaviour. Aust J Psychol 47(3):171–177CrossRefGoogle Scholar
  28. Felitti MD, Vincent J, Anda MD, Robert F, Nordenberg MD, Williamson MS, James S (1998) Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: the Adverse Childhood Experiences (ACE) Study. Am J Prev Med 14(4):245–258PubMedCrossRefGoogle Scholar
  29. Fraley RC, Shaver PR (1997) Adult attachment and the suppression of unwanted thoughts. J Pers Soc Psychol 73(5):1080PubMedCrossRefGoogle Scholar
  30. Fraley RC, Shaver PR (2000) Adult romantic attachment: theoretical developments, emerging controversies, and unanswered questions. Rev Gen Psychol 4(2):132CrossRefGoogle Scholar
  31. Fraley RC, Davis KE, Shaver PR (1998) Dismissing-avoidance and the defensive organization of emotion, cognition, and behavior. In: Simpson JA, Rholes WS (eds) Attachment theory and close relationships. Guilford, New York, pp 249–279Google Scholar
  32. Fries E, Hesse J, Hellhammer J, Hellhammer DH (2005) A new view on hypocortisolism. Psychoneuroendocrinology 30(10):1010–1016PubMedCrossRefGoogle Scholar
  33. Fries E, Dettenborn L, Kirschbaum C (2009) The cortisol awakening response (CAR): facts and future directions. Int J Psychophysiol 72(1):67–73PubMedCrossRefGoogle Scholar
  34. Gerra G, Zaimovic A, Mascetti GG, Gardini S, Zambelli U, Timpano M, Brambilla F (2001) Neuroendocrine responses to experimentally-induced psychological stress in healthy humans. Psychoneuroendocrinology 26(1):91–107PubMedCrossRefGoogle Scholar
  35. Glaser R, Kiecolt-Glaser JK (2005) Stress-induced immune dysfunction: implications for health. Nat Rev Immunol 5(3):243–251PubMedCrossRefGoogle Scholar
  36. Glaser R, Litsky ML, Padgett DA, Baiocchi RA, Yang EV, Chen M, Williams MV (2006) EBV-encoded dUTPase induces immune dysregulation: implications for the pathophysiology of EBV-associated disease. Virology 346(1):205–218PubMedCrossRefGoogle Scholar
  37. Goldberg S, MacKay-Soroka S, Rochester M (1994) Affect, attachment, and maternal responsiveness. Infant Behav Dev 17(3):335–339CrossRefGoogle Scholar
  38. Gouin JP, Glaser R, Loving TJ, Malarkey WB, Stowell J, Houts C, Kiecolt-Glaser JK (2009) Attachment avoidance predicts inflammatory responses to marital conflict. Brain Behav Immun 23(7):898–904PubMedCentralPubMedCrossRefGoogle Scholar
  39. Gunnar MR (1998) Quality of early care and buffering of neuroendocrine stress reactions: potential effects on the developing human brain. Prev Med 27(2):208–211PubMedCrossRefGoogle Scholar
  40. Gunnar MR, Brodersen L, Nachmias M, Buss K, Rigatuso J (1996) Stress reactivity and attachment security. Dev Psychobiol 29(3):191–204PubMedCrossRefGoogle Scholar
  41. Hamer M, Endrighi R, Venuraju SM, Lahiri A, Steptoe A (2012) Cortisol responses to mental stress and the progression of coronary artery calcification in healthy men and women. PLoS One 7(2), e31356PubMedCentralPubMedCrossRefGoogle Scholar
  42. Harris TB, Ferrucci L, Tracy RP, Corti MC, Wacholder S, Ettinger WH Jr, Wallace R (1999) Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med 106(5):506–512PubMedCrossRefGoogle Scholar
  43. Hazan C, Shaver P (1987) Romantic love conceptualized as an attachment process. J Pers Soc Psychol 52(3):511PubMedCrossRefGoogle Scholar
  44. Heim C, Ehlert U, Hellhammer DH (2000) The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology 25(1):1–35PubMedCrossRefGoogle Scholar
  45. Hicks AM, Diamond LM (2011) Don’t go to bed angry: attachment, conflict, and affective and physiological reactivity. Pers Relat 18(2):266–284CrossRefGoogle Scholar
  46. Irwin MR, Cole SW (2011) Reciprocal regulation of the neural and innate immune systems. Nat Rev Immunol 11(9):625–632PubMedCentralPubMedCrossRefGoogle Scholar
  47. Jaremka LM, Glaser R, Loving TJ, Malarkey WB, Stowell JR, Kiecolt-Glaser JK (2013) Attachment anxiety is linked to alterations in cortisol production and cellular immunity. Psychol Sci 24(3):272–279PubMedCrossRefGoogle Scholar
  48. Juster RP, McEwen BS, Lupien SJ (2010) Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobehav Rev 35(1):2–16PubMedCrossRefGoogle Scholar
  49. Kaptoge S, Seshasai SRK, Gao P, Freitag DF, Butterworth AS, Borglykke A, Danesh J (2013) Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis. Eur Heart J. doi: 10.1093/eurheartj/eht367 PubMedCentralPubMedGoogle Scholar
  50. Kidd T, Sheffield D (2005) Attachment style and symptom reporting: examining the mediating effects of anger and social support. Br J Health Psychol 10(4):531–541PubMedCrossRefGoogle Scholar
  51. Kidd T, Hamer M, Steptoe A (2011) Examining the association between adult attachment style and cortisol responses to acute stress. Psychoneuroendocrinology 36(6):771–779PubMedCentralPubMedCrossRefGoogle Scholar
  52. Kidd T, Hamer M, Steptoe A (2013) Adult attachment style and cortisol responses across the day in older adults. Psychophysiology 50(9):841–847PubMedCentralPubMedCrossRefGoogle Scholar
  53. Kidd T, Carvalho LA, Steptoe A (2014a) The relationship between cortisol responses to laboratory stress and cortisol profiles in daily life. Biol Psychol 99:34–40PubMedCentralPubMedCrossRefGoogle Scholar
  54. Kidd T, Poole L, Leigh E, Ronaldson A, Jahangiri M, Steptoe A (2014b) Attachment anxiety predicts IL-6 and length of hospital stay in coronary artery bypass graft surgery (CABG) patients. J Psychosom Res 77(2):155–157PubMedCentralPubMedCrossRefGoogle Scholar
  55. Kirschbaum C, Klauer T, Filipp SH, Hellhammer DH (1995) Sex-specific effects of social support on cortisol and subjective responses to acute psychological stress. Psychosom Med 57(1):23–31PubMedCrossRefGoogle Scholar
  56. Kumari M, Shipley M, Stafford M, Kivimaki M (2011) Association of diurnal patterns in salivary cortisol with all-cause and cardiovascular mortality: findings from the Whitehall II study. J Clin Endocrinol Metab 96(5):1478–1485PubMedCentralPubMedCrossRefGoogle Scholar
  57. Kunz-Ebrecht SR, Mohamed-Ali V, Feldman PJ, Kirschbaum C, Steptoe A (2003) Cortisol responses to mild psychological stress are inversely associated with proinflammatory cytokines. Brain Behav Immun 17(5):373–383PubMedCrossRefGoogle Scholar
  58. Laurent H, Powers S (2007) Emotion regulation in emerging adult couples: temperament, attachment, and HPA response to conflict. Biol Psychol 76(1):61–71PubMedCentralPubMedCrossRefGoogle Scholar
  59. Lazarus RS, Folkman S (1984) Stress. Appraisal and coping 456Google Scholar
  60. Libby P (2007) Inflammatory mechanisms: the molecular basis of inflammation and disease. Nutr Rev 65(s3):S140–S146PubMedCrossRefGoogle Scholar
  61. Lueken L, Lemery K (2004) Early caregiving and physiological stress response. Clin Psychol Rev 24(2):171–191CrossRefGoogle Scholar
  62. Lupien SJ, McEwen BS (1997) The acute effects of corticosteroids on cognition: integration of animal and human model studies. Brain Res Rev 24(1):1–27PubMedCrossRefGoogle Scholar
  63. Lupien SJ, McEwen BS, Gunnar MR, Heim C (2009) Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci 10(6):434–445PubMedCrossRefGoogle Scholar
  64. Maunder RG, Hunter JJ (2001) Attachment and psychosomatic medicine: developmental contributions to stress and disease. Psychosom Med 63(4):556–567PubMedCrossRefGoogle Scholar
  65. Maunder RG, Lancee WJ, Hunter JJ, Greenberg GR, Steinhart AH (2005) Attachment insecurity moderates the relationship between disease activity and depressive symptoms in ulcerative colitis. Inflamm Bowel Dis 11(10):919–926PubMedCrossRefGoogle Scholar
  66. Maunder RG, Lancee WJ, Nolan RP, Hunter JJ, Tannenbaum DW (2006) The relationship of attachment insecurity to subjective stress and autonomic function during standardized acute stress in healthy adults. J Psychosom Res 60(3):283–290PubMedCrossRefGoogle Scholar
  67. Maunder RG, Peladeau N, Savage D, Lancee WJ (2010) The prevalence of childhood adversity among healthcare workers and its relationship to adult life events, distress and impairment. Child Abuse Negl 34(2):114–123PubMedCrossRefGoogle Scholar
  68. McEwen BS (1998) Stress, adaptation, and disease: allostasis and allostatic load. Ann N Y Acad Sci 840(1):33–44PubMedCrossRefGoogle Scholar
  69. McEwen BS (2000a) Allostasis and allostatic load: implications for neuropsychopharmacology. Neuropsychopharmacology 22(2):108–124PubMedCrossRefGoogle Scholar
  70. McEwen BS (2000b) Effects of adverse experiences for brain structure and function. Biol Psychiatry 48(8):721–731PubMedCrossRefGoogle Scholar
  71. McEwen BS (2007) Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 87(3):873–904PubMedCrossRefGoogle Scholar
  72. McEwen BS (2008) Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol 583(2):174–185PubMedCentralPubMedCrossRefGoogle Scholar
  73. McWilliams LA, Bailey SJ (2010) Associations between adult attachment ratings and health conditions: evidence from the National Comorbidity Survey Replication. Health Psychol 29(4):446PubMedCrossRefGoogle Scholar
  74. Mikulincer M, Florian V (1998) The relationship between adult attachment styles and emotional and cognitive reactions to stressful events. In: Simpson JA, Rholes WS, editors. Attachment Theory and Close Relationships. Guildford Press, New York, pp. 143–165Google Scholar
  75. Mikulincer M, Gillath O, Shaver PR (2002) Activation of the attachment system in adulthood: threat-related primes increase the accessibility of mental representations of attachment figures. J Pers Soc Psychol 83(4):881PubMedCrossRefGoogle Scholar
  76. Mikulincer M, Shaver PR, Pereg D (2003) Attachment theory and affect regulation: the dynamics, development, and cognitive consequences of attachment-related strategies. Motiv Emot 27(2):77–102CrossRefGoogle Scholar
  77. Newell-Price J, Bertagna X, Grossman AB, Nieman LK (2006) Cushing’s syndrome. Lancet 367(9522):1605–1617PubMedCrossRefGoogle Scholar
  78. Nijm J, Jonasson L (2009) Inflammation and cortisol response in coronary artery disease. Ann Med 41(3):224–233PubMedCrossRefGoogle Scholar
  79. O’Donovan G, Blazevich AJ, Boreham C, Cooper AR, Crank H, Ekelund U, Stamatakis E (2010) The ABC of physical activity for health: a consensus statement from the British Association of Sport and Exercise Sciences. J Sports Sci 28(6):573–591PubMedCrossRefGoogle Scholar
  80. Picardi A, Battisti F, Tarsitani L, Baldassari M, Copertaro A, Mocchegiani E, Biondi M (2007) Attachment security and immunity in healthy women. Psychosom Med 69(1):40–46PubMedCrossRefGoogle Scholar
  81. Pierrehumbert B, Torrisi R, Glatz N, Dimitrova N, Heinrichs M, Halfon O (2009) The influence of attachment on perceived stress and cortisol response to acute stress in women sexually abused in childhood or adolescence. Psychoneuroendocrinology 34(6):924–938PubMedCrossRefGoogle Scholar
  82. Pietromonaco PR, Greenwood D, Barrett LF (2004) Conflict in adult close relationships. In: Rholes WS, Simpson JA (eds) Adult attachment: theory, research, and clinical implications. Guilford, New YorkGoogle Scholar
  83. Pietromonaco PR, Barrett LF, Powers SI (2006) Adult attachment theory and affective reactivity and regulation. In: Snyder DK, Simpson JA, Hughes JN (eds) Emotion regulation in families and close relationships: pathways to dysfunction and health. American Psychological Association, Washington D.C., pp 57–74Google Scholar
  84. Pietromonaco PR, DeBuse CJ, Powers SI (2013) Does attachment get under the skin? Adult romantic attachment and cortisol responses to stress. Curr Dir Psychol Sci 22(1):63–68PubMedCentralPubMedCrossRefGoogle Scholar
  85. Powers SI, Pietromonaco PR, Gunlicks M, Sayer A (2006) Dating couples’ attachment styles and patterns of cortisol reactivity and recovery in response to a relationship conflict. J Pers Soc Psychol 90(4):613PubMedCrossRefGoogle Scholar
  86. Puig J, Englund MM, Simpson JA, Collins WA (2013) Predicting adult physical illness from infant attachment: a prospective longitudinal study. Health Psychol 32(4):409PubMedCentralPubMedCrossRefGoogle Scholar
  87. Quirin M, Pruessner JC, Kuhl J (2008) HPA system regulation and adult attachment anxiety: individual differences in reactive and awakening cortisol. Psychoneuroendocrinology 33(5):581–590PubMedCrossRefGoogle Scholar
  88. Raison CL, Miller AH (2003) When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatr 160(9):1554–1565PubMedCrossRefGoogle Scholar
  89. Repetti RL, Taylor SE, Seeman TE (2002) Risky families: family social environments and the mental and physical health of offspring. Psychol Bull 128(2):330PubMedCrossRefGoogle Scholar
  90. Rifkin-Graboi A (2008) Attachment status and salivary cortisol in a normal day and during simulated interpersonal stress in young men. Stress: The International Journal on the Biology of Stress 11(3):210–224CrossRefGoogle Scholar
  91. Robles TF, Carroll JE (2011) Restorative biological processes and health. Soc Personal Psychol Compass 5(8):518–537PubMedCentralPubMedCrossRefGoogle Scholar
  92. Robles TF, Kane HS (2014) The attachment system and physiology in adulthood: normative processes, individual differences, and implications for health. J Pers 82(6):515–527PubMedCrossRefGoogle Scholar
  93. Sanchez M, Ladd CO, Plotsky PM (2001) Early adverse experience as a developmental risk factor for later psychopathology: evidence from rodent and primate models. Dev Psychopathol 13(03):419–449PubMedCrossRefGoogle Scholar
  94. Sanders J, Hawe E, Brull DJ, Hubbart C, Lowe G, Rumley A, Montgomery HE (2009) Higher IL-6 levels but not IL6–174G> C or− 572G> C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery. Atherosclerosis 204(1):196–201PubMedCrossRefGoogle Scholar
  95. Sapolsky RM, Romero LM, Munck AU (2000) How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions 1. Endocr Rev 21(1):55–89PubMedGoogle Scholar
  96. Segerstrom SC, Miller GE (2004) Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull 130(4):601PubMedCentralPubMedCrossRefGoogle Scholar
  97. Segerstrom SC, O’Connor DB (2012) Stress, health and illness: four challenges for the future. Psychol Health 27(2):128–140PubMedCrossRefGoogle Scholar
  98. Shaver PR, Mikulincer M (2007) Adult attachment strategies and the regulation of emotion. In: Gross JJ (ed) Handbook of emotion regulation. Guilford, New York, pp 446–465Google Scholar
  99. Smeets T (2010) Autonomic and hypothalamic–pituitary–adrenal stress resilience: impact of cardiac vagal tone. Biol Psychol 84(2):290–295PubMedCrossRefGoogle Scholar
  100. Stassen FR, Vega-Córdova X, Vliegen I, Bruggeman CA (2006) Immune activation following cytomegalovirus infection: more important than direct viral effects in cardiovascular disease? J Clin Virol 35(3):349–353PubMedCrossRefGoogle Scholar
  101. Steptoe A (1991) Invited review: the links between stress and illness. J Psychosom Res 35(6):633–644PubMedCrossRefGoogle Scholar
  102. Steptoe A, Kivimäki M (2012) Stress and cardiovascular disease. Nat Rev Cardiol 9(6):360–370PubMedCrossRefGoogle Scholar
  103. Steptoe A, Marmot M (2002) The role of psychobiological pathways in socio-economic inequalities in cardiovascular disease risk. Eur Heart J 23(1):13–25PubMedCrossRefGoogle Scholar
  104. Steptoe A, Hamer M, Chida Y (2007) The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis. Brain Behav Immun 21(7):901–912PubMedCrossRefGoogle Scholar
  105. Sterling P, Eyer J (1988) Allostasis: a new paradigm to explain arousal pathology. In: Fisher S, Reason J, editors. Handbook of life stress, cognition and health. New York, John Wiley & Sons, p. 629–649Google Scholar
  106. Stroud LR, Salovey P, Epel ES (2002) Sex differences in stress responses: social rejection versus achievement stress. Biol Psychiatry 52(327):318PubMedCrossRefGoogle Scholar
  107. Taylor SE (2010) Mechanisms linking early life stress to adult health outcomes. Proc Natl Acad Sci 107(19):8507–8512PubMedCentralPubMedCrossRefGoogle Scholar
  108. Teicher MH, Andersen SL, Polcari A, Anderson CM, Navalta CP, Kim DM (2003) The neurobiological consequences of early stress and childhood maltreatment. Neurosci Biobehav Rev 27(1):33–44PubMedCrossRefGoogle Scholar
  109. Thorp AA, Owen N, Neuhaus M, Dunstan DW (2011) Sedentary behaviors and subsequent health outcomes in adults: a systematic review of longitudinal studies, 1996–2011. Am J Prev Med 41(2):207–215PubMedCrossRefGoogle Scholar
  110. Whitworth JA, Williamson PM, Mangos G, Kelly JJ (2005) Cardiovascular consequences of cortisol excess. Vasc Health Risk Manag 1(4):291PubMedCentralPubMedCrossRefGoogle Scholar

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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Psychobiology Group, Department of Epidemiology and Public HealthUniversity College LondonLondonUK

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