Aesthetic Procedures for Increased Lip Volume: Hyaluronic Acid Fillers in Nonsurgical Lip and Eye Rejuvenation Techniques

  • Giselle Prado
  • Sonal Choudhary
  • Martin ZaiacEmail author


Patients often present for lip augmentation to correct the loss of volume and signs of aging commonly perceived with perioral aging, including but not limited to decreased vermillion showing, blunting of the Cupid’s bow, less visible white roll, vertical rhytids, marionette lines, formation of a mentalis crease, and deep nasolabial folds. Hyaluronic acid (HA) is popular filler for temporary lip augmentation (effects last 3–6 months) due to its hygroscopic properties and resulting natural appearance. Additionally, they have desirable safety profiles due to the reversibility by enzymatic degradation using hyalurodinase. Keeping in mind the important anatomy of the perioral region and its vascular supply and nerve innervation is essential to a successful procedure with good cosmetic results. This chapter includes detailed guidelines and a technique for injecting. Physicians should consult with patients as to their preferences for a desired look, but carefully manage expectations to avoid disappointments. HA fillers are well tolerated and rarely result in adverse reactions for patients. Commonly experienced reactions can include local inflammation, tenderness, and bruising. HA fillers are an effective first-line treatment option for patients who want to augment and revitalize their lips.


Hyaluronic Acid Vermillion Border Perioral Region Labial Artery Hyaluronic Acid Filler 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Ali MJ, Ende K, Maas CS (2007) Perioral rejuvenation and lip augmentation. Facial Plast Surg Clin North Am 15(4):491–500, viiCrossRefPubMedGoogle Scholar
  2. 2.
    Sundaram H, Cassuto D (2013) Biophysical characteristics of hyaluronic acid soft-tissue fillers and their relevance to aesthetic applications. Plast Reconstr Surg 132(4 Suppl 2):5S–21SCrossRefPubMedGoogle Scholar
  3. 3.
    Hotta T (2006) Understanding the anatomy when using dermal fillers enhances patient safety. Plast Surg Nurs 26(3):149–151CrossRefPubMedGoogle Scholar
  4. 4.
    Perkins SW, Sandel HD (2007) Anatomic considerations, analysis, and the aging process of the perioral region. Facial Plast Surg Clin North Am 15(4):403–407, vCrossRefPubMedGoogle Scholar
  5. 5.
    Vleggaar D, Fitzgerald R (2008) Dermatological implications of skeletal aging: a focus on supraperiosteal volumization for perioral rejuvenation. J Drugs Dermatol 7(3):209–220PubMedGoogle Scholar
  6. 6.
    Koger C, Cohen J (2014) The lasting effects of fillers through neocollagenesis. Dermatologist 22(4)Google Scholar
  7. 7.
    Cartier H, Trevidic P, Rzany B et al (2012) Perioral rejuvenation with a range of customized hyaluronic acid fillers: efficacy and safety over six months with a specific focus on the lips. J Drugs Dermatol 11(1 Suppl):s17–s26PubMedGoogle Scholar
  8. 8.
    Soft Tissue Fillers Approved by the Center for Devices and Radiological Health. U.S. Food and Drug Administration. Accessed October 29, 2014.Google Scholar
  9. 9.
    Sarnoff DS, Gotkin RH (2012) Six steps to the “perfect” lip. J Drugs Dermatol 11(9):1081–1088PubMedGoogle Scholar
  10. 10.
    Monheit GD, Coleman KM (2006) Hyaluronic acid fillers. Dermatol Ther 19(3):141–150CrossRefPubMedGoogle Scholar
  11. 11.
    Eccleston D, Murphy DK (2012) Juvéderm(®) Volbella™ in the perioral area: a 12-month prospective, multicenter, open-label study. Clin Cosmet Investig Dermatol 5:167–172PubMedPubMedCentralGoogle Scholar
  12. 12.
    Goodman G (2012) Duckless lips: how to rejuvenate the older lip naturally and appropriately. Cosmetic Dermatol 25(6):276Google Scholar
  13. 13.
    Monheit GD (2007) Hyaluronic acid fillers: Hylaform and Captique. Facial Plast Surg Clin North Am 15(1):77–84, viiCrossRefPubMedGoogle Scholar
  14. 14.
    Carruthers A, Carruthers J, Hardas B et al (2008) A validated lip fullness grading scale. Dermatol Surg 34(Suppl 2):S161–S166PubMedGoogle Scholar
  15. 15.
    Zaidel DW, Deblieck C (2007) Attractiveness of natural faces compared to computer constructed perfectly symmetrical faces. Int J Neurosci 117(4):423–431CrossRefPubMedGoogle Scholar
  16. 16.
    Cox SE, Adigun CG (2011) Complications of injectable fillers and neurotoxins. Dermatol Ther 24(6):524–536CrossRefPubMedGoogle Scholar
  17. 17.
    Gilbert E, Hui A, Meehan S, Waldorf HA (2012) The basic science of dermal fillers: past and present part II: adverse effects. J Drugs Dermatol 11(9):1069–1077PubMedGoogle Scholar
  18. 18.
    Vent J, Lefarth F, Massing T, Angerstein W (2014) Do you know where your fillers go? An ultrastructural investigation of the lips. Clin Cosmet Investig Dermatol 7:191–199CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Eversole R, Tran K, Hansen D, Campbell J (2013) Lip augmentation dermal filler reactions, histopathologic features. Head Neck Pathol 7(3):241–249CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of Dermatology, Herbert Wertheim College of MedicineFlorida International UniversityMiamiUSA
  2. 2.Department of DermatologyUniversity of Miami Miller School of MedicineMiamiUSA
  3. 3.Greater Miami Skin and Laser CenterMiamiUSA

Personalised recommendations