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Practical Atlas of Transplant Pathology pp 173–185Cite as

Post-transplantation Lymphoproliferative Disorders

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Abstract

Post-transplant lymphoproliferative disorders (PTLDs) comprise a wide spectrum of lymphoproliferative disorders that may be difficult to classify. They are potentially lethal, but clinical behavior is not always predictable from the histologic appearance. Factors that contribute to the development of PTLD include the type of transplant (solid organ versus bone marrow), degree of immunosuppression (which in turn generally relates to the type and duration of immunosuppressive therapy), HLA type, and viral status of the individual patient at the time of transplantation. Although the majority of cases of PTLDs are related to infection with the Epstein-Barr virus (EBV), there remains a subset of EBV-negative lymphomas that are less well-characterized. The spectrum of B-cell and N/K T-cell proliferations is illustrated from aggressive lymphomas to indolent localized EBV-related mucocutaneous ulcers.

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References

  1. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri S, Stein H, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. Geneva: WHO Press; 2008.

    Google Scholar 

  2. Nassif S, Kaufman S, Vahdat S, Yazigi N, Kallakury B, Island E, et al. Clinicopathologic features of post-transplant lymphoproliferative disorders arising after pediatric small bowel transplant. Pediatr Transplant. 2013;17:765–73.

    Article  CAS  PubMed  Google Scholar 

  3. Weintraub L, Weiner C, Miloh T, Tomaino J, Joashi U, Benchimol C, et al. Identifying predictive factors for posttransplant lymphoproliferative disease in pediatric solid organ transplant recipients with Epstein-Barr virus viremia. J Pediatr Hematol Oncol. 2014;36:e481–6.

    Article  CAS  PubMed  Google Scholar 

  4. Rasche L, Kapp M, Einsele H, Mielke S. EBV-induced post transplant lymphoproliferative disorders: a persisting challenge in allogeneic hematopoetic SCT. Bone Marrow Transplant. 2014;49:163–7.

    Article  CAS  PubMed  Google Scholar 

  5. Styczynski J, Gil L, Tridello G, Ljungman P, Donnelly JP, van der Velden W, et al. Response to rituximab-based therapy and risk factor analysis in epstein barr virus-related lymphoproliferative disorder after hematopoietic stem cell transplant in children and adults: a study from the infectious diseases working party of the european group for blood and marrow transplantation. Clin Infect Dis. 2013;57:794–802.

    Article  CAS  PubMed  Google Scholar 

  6. Evens AM, David KA, Helenowski I, Nelson B, Kaufman D, Kircher SM, et al. Multicenter analysis of 80 solid organ transplantation recipients with post-transplantation lymphoproliferative disease: outcomes and prognostic factors in the modern era. J Clin Oncol. 2010;28:1038–46.

    Article  PubMed Central  PubMed  Google Scholar 

  7. Zimmermann H, Trappe RU. EBV and posttransplantation lymphoproliferative disease: What to do? Hematology Am Soc Hematol Educ Program. 2013;2013:95–102.

    Article  PubMed  Google Scholar 

  8. Piccin A, Morello E, Svaldi M, Haferlach T, Facchetti F, Negri G, et al. Post-transplant lymphoproliferative disease of donor origin, following haematopoietic stem cell transplantation in a patient with blastic plasmacytoid dendritic cell neoplasm. Hematol Oncol. 2012;30:210–3.

    Article  CAS  PubMed  Google Scholar 

  9. Khedmat H, Taheri S. Post-transplantation lymphoproliferative disorders localizing in the adenotonsillar region: report from the PTLD Int. Suvey. Ann Transplant. 2011;16:109–16.

    Article  PubMed  Google Scholar 

  10. Cesarman E, Chadburn A, Liu YF, Migliazza A, Dalla-Favera R, Knowles DM. BCL-6 gene mutations in posttransplantation lymphoproliferative disorders predict response to therapy and clinical outcome. Blood. 1998;92:2294–302.

    CAS  PubMed  Google Scholar 

  11. Chadburn A, Chen JM, Hsu DT, Frizzera G, Cesarman E, Garrett TJ, et al. The morphologic and molecular genetic categories of posttransplantation lymphoproliferative disorders are clinically relevant. Cancer. 1998;82:1978–87.

    Article  CAS  PubMed  Google Scholar 

  12. Zimmermann H, Choquet S, Dierickx D, Dreyling MH, Moore J, Valentin A, et al. Early and late posttransplant lymphoproliferative disorder after lung transplantation--34 cases from the European PTLD Network. Transplantation. 2013;96:e18–9.

    Article  PubMed  Google Scholar 

  13. Zimmermann H, Reinke P, Neuhaus R, Lehmkuhl H, Oertel S, Atta J, et al. Burkitt post-transplantation lymphoma in adult solid organ transplant recipients: sequential immunochemotherapy with rituximab (R) followed by cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or R-CHOP, is safe and effective in an analysis of 8 patients. Cancer. 2012;118:4715–24.

    Article  CAS  PubMed  Google Scholar 

  14. Picarsic J, Jaffe R, Mazariegos G, Webber SA, Ellis D, Green MD, et al. Post-transplant Burkitt lymphoma is a more aggressive and distinct form of post-transplant lymphoproliferative disorder. Cancer. 2011;117:4540–50.

    Article  PubMed  Google Scholar 

  15. Karuturi M, Shah N, Frank D, Fasan O, Reshef R, Ahya VN, et al. Plasmacytic post-transplant lymphoproliferative disorder: a case series of nine patients. Transpl Int. 2013;26:616–22.

    Article  CAS  PubMed  Google Scholar 

  16. Nalesnik MA. Plasma cell tumors in transplant patients. Blood. 2013;121:1247–9.

    Article  CAS  PubMed  Google Scholar 

  17. Hart M, Thakral B, Yohe S, Balfour Jr HH, Singh C, Spears M, et al. EBV-positive mucocutaneous ulcer in organ transplant recipients: a localized indolent posttransplant lymphoproliferative disorder. Am J Surg Pathol. 2014;38:1522–9.

    Article  PubMed  Google Scholar 

  18. Johnson LR, Nalesnik MA, Swerdlow SH. Impact of Epstein-Barr virus in monomorphic B-cell posttransplant lymphoproliferative disorders: a histogenetic study. Am J Surg Pathol. 2006;30:1604–12.

    Article  PubMed  Google Scholar 

  19. Nelson BP, Nalesnik MA, Bahler DW, Locker J, Fung JJ, Swerdlow SH. Epstein-Barr virus-negative post-transplant lymphoproliferative disorders: a distinct entity? Am J Surg Pathol. 2000;24:375–85.

    Article  CAS  PubMed  Google Scholar 

  20. Craig FE, Johnson LR, Harvey SA, Nalesnik MA, Luo JH, Bhattacharya SD, et al. Gene expression profiling of Epstein-Barr virus-positive and -negative monomorphic B-cell posttransplant lymphoproliferative disorders. Diagn Mol Pathol. 2007;16:158–68.

    Article  CAS  PubMed  Google Scholar 

  21. Herreman A, Dierickx D, Morscio J, Camps J, Bittoun E, Verhoef G, et al. Clinicopathological characteristics of posttransplant lymphoproliferative disorders of T-cell origin: single-center series of nine cases and meta-analysis of 147 reported cases. Leuk Lymphoma. 2013;54:2190–9.

    Article  CAS  PubMed  Google Scholar 

  22. Kraus TS, Twist CJ, Tan BT. Angioimmunoblastic T cell lymphoma: an unusual presentation of posttransplant lymphoproliferative disorder in a pediatric patient. Acta Haematol. 2014;131:95–101.

    Article  PubMed  Google Scholar 

  23. Tiede C, Maecker-Kolhoff B, Klein C, Kreipe H, Hussein K. Risk factors and prognosis in T-cell posttransplantation lymphoproliferative diseases: reevaluation of 163 cases. Transplantation. 2013;95:479–88.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA

    Jonathan Said MD

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  1. Jonathan Said MD
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Correspondence to Jonathan Said MD .

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Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA

    W. Dean Wallace

  2. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA

    Bita V. Naini

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© 2016 Springer International Publishing Switzerland

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Said, J. (2016). Post-transplantation Lymphoproliferative Disorders. In: Wallace, W., Naini, B. (eds) Practical Atlas of Transplant Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-23054-2_9

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  • DOI: https://doi.org/10.1007/978-3-319-23054-2_9

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-23053-5

  • Online ISBN: 978-3-319-23054-2

  • eBook Packages: MedicineMedicine (R0)

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