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An Energy Model for Detecting Community in PPI Networks

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Database and Expert Systems Applications (Globe 2015, DEXA 2015)

Abstract

Community detection problem has been studied for years, but no agreement on the common definition of community has been reached till now. One topology is found to be of different types, unipartite or bipartite/multipartite. The previous literatures mostly proposed only one type of community. As the definition of community is understood differently, the grouping results are always applicable to some specified networks. If the definition changes, the grouping result will no longer be “good”. In the present paper, it’s found that some vertices “must be” in the same community, while some maybe in or not in the same community. To do the community detection on mixed protein-protein interaction (PPI) networks, an energy model with two steps is proposed. First, vertices that “must be” in the same community are grouped together by properties; second, overlapping vertices are found by functions. In the energy model, “positive energy” is defined by attraction generated between two vertices, and “negative energy” by the attraction, which weakens the attraction between the corresponding two vertices, resulting from other vertices. Energy between two vertices is the sum of their positive and negative energy. Computing the energy of each community, the community structure can be found when maximum value of the energy sum of these communities is obtained. The model is utilized to find community structure in PPI networks. The results show that the energy model is applicable to unipartite, bipartite or mixed PPI networks. Vertices with similar property/roles in the same community and overlapping vertices are found for the network.

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Correspondence to Lin Bai .

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Pang, Y., Bai, L., Bu, K. (2015). An Energy Model for Detecting Community in PPI Networks. In: Chen, Q., Hameurlain, A., Toumani, F., Wagner, R., Decker, H. (eds) Database and Expert Systems Applications. Globe DEXA 2015 2015. Lecture Notes in Computer Science(), vol 9261. Springer, Cham. https://doi.org/10.1007/978-3-319-22849-5_9

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  • DOI: https://doi.org/10.1007/978-3-319-22849-5_9

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-22848-8

  • Online ISBN: 978-3-319-22849-5

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