Abstract
In recent decades, annonaceous acetogenins have become highly studied plant secondary metabolites in terms of their isolation, structure elucidation, synthesis, biological evaluation, mechanism of action, and toxicity. The aim of the present contribution is to summarize chemical and biological reports published since 1997 on annonaceous acetogenins and synthetic acetogenin mimics. The compounds are considered biologically in terms of their cytotoxicity for cancer cell lines, neurotoxicity, pesticidal effects, and miscellaneous activities.
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Acknowledgments
This work was supported by grants from the Ministry of Science and Technology (National Science Council) of Taiwan NSC100-2320-B-110-001-MY2 awarded to C.C.L., MOST 103-2320-B-037-005-MY2 & 102-2628-B-037-003-MY3 awarded to F.R.C., and NSC 103-2911-I-002-303, NSC101-2632-B039-001-MY3, NSC100-2320-B-110-001-MY2 National Health Research Institutes NHRI-EX102-10241BI, and CMU under the Aim for Top University Plan of the Ministry of Education, Taiwan award to Y.C.W. as well as the Excellence for Cancer Research Center Grant, the Ministry of Health and Welfare, Executive Yuan, Taipei, Taiwan (MOHW104-TDU-B-212-124-003) and the grant for Health and Welfare Surcharge of Tobacco Products.
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Liaw, CC., Liou, JR., Wu, TY., Chang, FR., Wu, YC. (2016). Acetogenins from Annonaceae. In: Kinghorn, A., Falk, H., Gibbons, S., Kobayashi, J. (eds) Progress in the Chemistry of Organic Natural Products 101. Progress in the Chemistry of Organic Natural Products, vol 101. Springer, Cham. https://doi.org/10.1007/978-3-319-22692-7_2
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