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Acetogenins from Annonaceae

  • Chih-Chuang Liaw
  • Jing-Ru Liou
  • Tung-Ying Wu
  • Fang-Rong Chang
  • Yang-Chang WuEmail author
Chapter
Part of the Progress in the Chemistry of Organic Natural Products book series (POGRCHEM, volume 101)

Abstract

In recent decades, annonaceous acetogenins have become highly studied plant secondary metabolites in terms of their isolation, structure elucidation, synthesis, biological evaluation, mechanism of action, and toxicity. The aim of the present contribution is to summarize chemical and biological reports published since 1997 on annonaceous acetogenins and synthetic acetogenin mimics. The compounds are considered biologically in terms of their cytotoxicity for cancer cell lines, neurotoxicity, pesticidal effects, and miscellaneous activities.

Keywords

Annonaceae Acetogenins Mitochondria complex I inhibition Pesticidal activity Anti-cancer activity Apoptosis Neurotoxicity Ionophores Acetogenin mimics Atypical Parkinsonism 

Notes

Acknowledgments

This work was supported by grants from the Ministry of Science and Technology (National Science Council) of Taiwan NSC100-2320-B-110-001-MY2 awarded to C.C.L., MOST 103-2320-B-037-005-MY2 & 102-2628-B-037-003-MY3 awarded to F.R.C., and NSC 103-2911-I-002-303, NSC101-2632-B039-001-MY3, NSC100-2320-B-110-001-MY2 National Health Research Institutes NHRI-EX102-10241BI, and CMU under the Aim for Top University Plan of the Ministry of Education, Taiwan award to Y.C.W. as well as the Excellence for Cancer Research Center Grant, the Ministry of Health and Welfare, Executive Yuan, Taipei, Taiwan (MOHW104-TDU-B-212-124-003) and the grant for Health and Welfare Surcharge of Tobacco Products.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Chih-Chuang Liaw
    • 1
  • Jing-Ru Liou
    • 2
  • Tung-Ying Wu
    • 2
  • Fang-Rong Chang
    • 2
  • Yang-Chang Wu
    • 3
    Email author
  1. 1.Department of Marine Biotechnology and ResourcesNational Sun Yat-sen UniversityKaohsiungTaiwan
  2. 2.Graduate Institute of Natural ProductsKaohsiung Medical UniversityKaohsiungTaiwan
  3. 3.School of Pharmacy, College of PharmacyChina Medical UniversityTaichungTaiwan

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