Heat-Based Tumor Ablation: Role of the Immune Response

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 880)


The ideal cancer therapy not only induces the death of all localized tumor cells with less damage to surrounding normal tissue, but also activates a systemic antitumor immunity. Heat-based tumor ablation has the potential to be such a treatment as it can minimal-invasively ablate a targeted tumor below the skin surface, and may subsequently augment host antitumor immunity. This chapter primarily introduces increasing pre-clinical and clinical evidence linking antitumor immune response to thermal tumor ablation, and then discusses the potential mechanisms involved in ablation-enhanced host antitumor immunity. The seminal studies performed so far indicate that although it is not possible to make definite conclusions on the connection between thermal ablation and antitumor immune response, it is nonetheless important to conduct extensive studies on the subject in order to elucidate the processes involved.


Heat Ablation Neoplasm Thermal ablation Immunity High intensity focused ultrasound Radiofrequency Microwave Laser Cryoablation Antigen presenting cell Cytotoxic T lymphocyte Tumor infiltrating lymphocyte Heat shock protein Tumor vaccine 


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Nuffield Department of Surgical SciencesHIFU Unit, Churchill Hospital, University of OxfordOxfordUK
  2. 2.Institute of Ultrasonic Engineering in MedicineCollege of Biomedical Engineering, Chongqing Medical UniversityChongqingChina

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