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Drug-Loaded Perfluorocarbon Nanodroplets for Ultrasound-Mediated Drug Delivery

  • Chapter
Therapeutic Ultrasound

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 880))

Abstract

The interaction of nanoparticles with directed energy is a novel application in targeted drug delivery. This chapter focuses on perfluorocarbon nanoemulsions, whose action in drug delivery depends on the ultrasound-triggered phase shift from liquid to gaseous state. These nanoemulsions have great potential for unloading encapsulated drugs at a desired time and location in the body in response to directed ultrasound. In addition, they actively alter their nano-environment for enhancing drug transport through various biological barriers to sites of action, which significantly enhances therapeutic outcome.

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Authors and Affiliations

  1. Department of Bioengineering, University of Utah, 36 South Wasatch Drive, Room, 3100, Salt Lake City, UT, 84112, USA

    Natalya Rapoport

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  1. Natalya Rapoport
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Correspondence to Natalya Rapoport .

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  1. Inserm U930 "Imagerie et Cerveau", Université François Rabelais de Tours - Faculté de Médecine, Tours Cedex 1, France

    Jean-Michel Escoffre

  2. Inserm U930 "Imagerie et Cerveau", Université François Rabelais de Tours - Faculté de Médecine, Tours Cedex 1, France

    Ayache Bouakaz

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Rapoport, N. (2016). Drug-Loaded Perfluorocarbon Nanodroplets for Ultrasound-Mediated Drug Delivery. In: Escoffre, JM., Bouakaz, A. (eds) Therapeutic Ultrasound. Advances in Experimental Medicine and Biology, vol 880. Springer, Cham. https://doi.org/10.1007/978-3-319-22536-4_13

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