Abstract
Normal serum magnesium (Mg2+) reference range is 0.7–1.1 mmol/L, of which 65–80 % is ionised and considered to be the physiologically useful portion in serum [1–4].
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Abbreviations
- ACE:
-
Angiotensin converting enzyme
- ATP:
-
Adenosin triphosphate
- BNF:
-
British National Formulary
- IMM:
-
Inner mitochondrial membrane
- MPTP:
-
Mitochondrial permeability transition pore
- NMR:
-
Nuclear magnetic resonance
- PTH:
-
Parathyroid hormone
References
Sharma PC, Vizcaychipi CM (2014) Magnesium: the neglected electrolyte? A clinical review. Pharmacol and Pharm 5:762–772
Markowitz JD, Narasimhan M (2008) Delirium and antipsychotics: a systematic review of epidemiology and somatic treatment options. Psychiatry (Edgmont) 5:29–36
Romani A (2007) Regulation of magnesium homeostasis and transport in mammalian cells. Arch Biochem Biophys 458:90–102
Swaminathan R (2003) Magnesium metabolism and its disorders. Clin Biochem Rev 24:47–66
Fawcett WJ, Haxby EJ, Male DA (1999) Magnesium: physiology and pharmacology. Br J Anaesth 83:302–320
Moskowitz A, Lee J, Donnino MW, Mark R, Celi LA, Danziger J (published online 2014) The association between admission magnesium concentrations and lactic acidosis in critical illness. J Intensive Care Med 10.1177/0885066614530659
Ayuk J, Gittoes NJ (2014) Contemporary view of the clinical relevance of magnesium homeostasis. Ann Clin Biochem 51:179–188
Quamme GA (1997) Renal magnesium handling: new insights in understanding old problems. Kidney Int 52:1180–1195
(2013) Evaluation and treatment of hypomagnesemia. 2015, at http://www.uptodate.com/contents/evaluation-and-treatment-of-hypomagnesemia?source=search_result&search=hypomagnesemia&selectedTitle=1~150
Safavi M, Honarmand A (2007) Admission hypomagnesemia – impact on mortality or morbidity in critically ill patients. Middle East J Anaesthesiol 19:645–660
Altura BM (1994) Introduction: importance of Mg in physiology and medicine and the need for ion selective electrodes. Scand J Clin Lab Invest Suppl 217:5–9
Halestrap AP, Clarke SJ, Javadov SA (2004) Mitochondrial permeability transition pore opening during myocardial reperfusion – a target for cardioprotection. Cardiovasc Res 61:372–385
Zamzami N, Kroemer G (2001) The mitochondrion in apoptosis: how Pandora’s box opens. Nat Rev Mol Cell Biol 2:67–71
Iseri LT, French JH (1984) Magnesium: nature’s physiologic calcium blocker. Am Heart J 108:188–193
Laver DR, Baynes TM, Dulhunty AF (1997) Magnesium inhibition of ryanodine-receptor calcium channels: evidence for two independent mechanisms. J Membr Biol 156:213–229
Kolte D, Vijayaraghavan K, Khera S, Sica DA, Frishman WH (2014) Role of magnesium in cardiovascular diseases. Cardiol Rev 22:182–192
Martin KJ, Gonzalez EA, Slatopolsky E (2009) Clinical consequences and management of hypomagnesemia. J Am Soc Nephrol 20:2291–2295
Schweigel M, Martens H (2000) Magnesium transport in the gastrointestinal tract. Front Biosci 5:D666–D677
Kraft MD, Btaiche IF, Sacks GS, Kudsk KA (2005) Treatment of electrolyte disorders in adult patients in the intensive care unit. Am J Health Syst Pharm 62:1663–1682
Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A (2000) Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta 294:1–26
Schuck P, Gammelin G, Resch KL (1998) Magnesium and phosphorus. Lancet 352:1474–1475; author reply 1475–1476
Huijgen HJ, Soesan M, Sanders R, Mairuhu WM, Kesecioglu J, Sanders GT (2000) Magnesium levels in critically ill patients. What should we measure? Am J Clin Pathol 114:688–695
(2015) Magnesium. 11 2015, at http://www.evidence.nhs.uk/formulary/bnf/current/9-nutrition-and-blood/95-minerals/951-calcium-and-magnesium/9513-magnesium
Komaki F, Akiyama T, Yamazaki T, Kitagawa H, Nosaka S, Shirai M (2013) Effects of intravenous magnesium infusion on in vivo release of acetylcholine and catecholamine in rat adrenal medulla. Auton Neurosci 177:123–128
Woods KL, Fletcher S, Roffe C, Haider Y (1992) Intravenous magnesium sulphate in suspected acute myocardial infarction: results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet 339:1553–1558
ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group (1995) ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. Lancet 345:669–85
Magnesium in Coronaries Trial I (2002) Early administration of intravenous magnesium to high-risk patients with acute myocardial infarction in the Magnesium in Coronaries (MAGIC) Trial: a randomised controlled trial. Lancet 360:1189–96
Nuytten D, Van Hees J, Meulemans A, Carton H (1991) Magnesium deficiency as a cause of acute intractable seizures. J Neurol 238:262–264
Altman D, Carroli G, Duley L et al (2002) Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Lancet 359:1877–1890
Rowe BH, Bretzlaff JA, Bourdon C, Bota GW, Camargo CA Jr (2000) Intravenous magnesium sulfate treatment for acute asthma in the emergency department: a systematic review of the literature. Ann Emerg Med 36:181–190
(2014) Symptoms of hypermagnesaemia. 2014, at http://www.uptodate.com/contents/symptoms-of-hypermagnesemia
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Bamgbose, F., Sharma, P. (2016). Magnesium and Cell Membrane Stability in the Critically Ill Patient. In: Vizcaychipi, M., Corredor, C. (eds) Key Topics in Management of the Critically Ill. Springer, Cham. https://doi.org/10.1007/978-3-319-22377-3_13
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