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Translational Medicine in Hepatitis B Virus: What Can We Learn from Clinical Samples?

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Hepatitis B Virus in Human Diseases

Part of the book series: Molecular and Translational Medicine ((MOLEMED))

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Abstract

Knowledge of the pathological mechanisms causing human diseases demands the use of in vitro and in vivo models, where different variables can be clearly controlled and where the impact of the effect of single genes, proteins, or cells can be consistently measured. Such reductionist approach cannot be applied in clinical samples, and for this reason experimental findings detected in clinical studies need to be defined in controlled models. On the other hand, it is questionable whether artificial experimental models can recapitulate natural disease. In this chapter we review the shortcomings of the current available in vivo and in vitro models of HBV infection and discuss how significant questions related to HBV pathogenesis can profit from a careful utilization of data derived from patients.

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Authors and Affiliations

  1. Emerging infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore, 169857, Singapore

    Antonio Bertoletti M.D.

  2. Singapore Institute for Clinical Sciences, A*STAR, Singapore, Singapore

    Antonio Bertoletti M.D.

  3. Cancer Research Center of Lyon (CRCL)—INSERM U1052, Lyon, France

    Fabien Zoulim

  4. Hepatology Department, Hospices Civils de Lyon, Lyon, France

    Fabien Zoulim

  5. Université de Lyon, Lyon, France

    Fabien Zoulim

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Correspondence to Antonio Bertoletti M.D. .

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Editors and Affiliations

  1. Chang Gung University, Chang Gung Memorial Hospital, Taipei, Taiwan

    Yun-Fan Liaw

  2. INSERM Unit 1052, Hospices Civils de Lyon, Lyon University, Lyon, France

    Fabien Zoulim

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Bertoletti, A., Zoulim, F. (2016). Translational Medicine in Hepatitis B Virus: What Can We Learn from Clinical Samples?. In: Liaw, YF., Zoulim, F. (eds) Hepatitis B Virus in Human Diseases. Molecular and Translational Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-22330-8_8

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  • DOI: https://doi.org/10.1007/978-3-319-22330-8_8

  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-22329-2

  • Online ISBN: 978-3-319-22330-8

  • eBook Packages: MedicineMedicine (R0)

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