A Highly Effective Immune System Predating Adaptive Immunity

  • Joseph G. SinkovicsEmail author


Stepwise diversification. The coeloma cavities of the deuterostome sea urchins (Strongylocentrotus purpuratus) mobilize monocyte-like cells, which respond to bacterial endotoxins. The diversity of the response of sea urchin coelomocytes to lipopolysaccharides was unexpectedly high: 81 full length cDNAs contained 67 unique nucleotide sequences (the 185/333 family) encoding 64 different proteins. Complement C3 was expressed, too.


Migration Inhibitory Factor Leucine Rich Repeat Adaptive Immune System Coeloma Cavity Strongylocentrotus Purpuratus 
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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.M.D. Anderson Hospital Comprehensive Cancer CenterThe University of TexasHoustonUSA
  2. 2.H.L. Moffitt Comprehensive Cancer CenterThe University of South FloridaTampaUSA
  3. 3.Department of Molecular MedicineThe University of South Florida Morsani College of MedicineTampaUSA
  4. 4.The Cancer InstituteSt. Joseph’s HospitalTampaUSA

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