• Joseph G. SinkovicsEmail author


Considerations elaborated on in this volume support the concept that the malignantly transformed cell is driven by an ancient, but well conserved substance of the RNA/DNA complex. In the pre-cellular world, RNA was the progenitor of the first DNA molecules. The one-exon Sox2 sequence remains preserved embedded in a long noncoding ncRNA strand in the human genome at 3q26.3-q27, as a relic of their ancient biophysical precellular relationship. The primordial RNA/DNA complex remains preserved in the archaea, and in the cells of unicellular, early multicellular, or advanced multicellular eukaryotic hosts as chloroplasts and mitochondria.


Chronic Lymphocytic Leukemia Lynch Syndrome Oncolytic Virus Human Cerebral Cortex Cellular Life 
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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.M.D. Anderson Hospital Comprehensive Cancer CenterThe University of TexasHoustonUSA
  2. 2.H.L. Moffitt Comprehensive Cancer CenterThe University of South FloridaTampaUSA
  3. 3.Department of Molecular MedicineThe University of South Florida Morsani College of MedicineTampaUSA
  4. 4.The Cancer InstituteSt. Joseph’s HospitalTampaUSA

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