Elementary Epigenomics

  • Joseph G. SinkovicsEmail author


The restless epigenome. Most histones form nucleosomes (octameric DNA compaction units). An array of transcription factors share DNA-binding sites in forming complexes with the chromatin modifying enzymes. These enzymes catalyze the give and take of low MW adducts (methyl, acetyl, phosphate groups). Some eukaryotic chromatins conserved motifs of archaeal and bacterial precursors of eukaryotic cells; even the phage of the mitochondrial 5α-proteobacterium might have contributed the gene for the HEH fold domain (helix-extended-region-helix) to its eukaryotic fusion partner.


White Spot Syndrome Virus Turner Syndrome Oral Contraceptive Pill Vide Supra Intron Density 
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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.M.D. Anderson Hospital Comprehensive Cancer CenterThe University of TexasHoustonUSA
  2. 2.H.L. Moffitt Comprehensive Cancer CenterThe University of South FloridaTampaUSA
  3. 3.Department of Molecular MedicineThe University of South Florida Morsani College of MedicineTampaUSA
  4. 4.The Cancer InstituteSt. Joseph’s HospitalTampaUSA

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