Errors or Inherent Attributes for the Sustenance of Unicellular Life
The ancient “cell survival pathways” of unicellular life forms become oncogenes in multicellular hosts. Proto-oncogenes are installed. The primordial physiological “cell survival pathways” PI3K; Wnt/catenin; Notch, as a “destabilizer” of catenin; NFκB; TGFβ, discovered as decapentaplegic, Dpp; Hedgehog, JAK/STAT were already operational in the cnidaria (a non-bilaterian). The hoglet gene of the choanoflagellate, Monosiga ovata, may be the ancestor of the Hh gene family.