Inbuilt Errors Not Yet Corrected

  • Joseph G. SinkovicsEmail author


The invasion of the tyrosine kinases can go out of control. The human genome operates 10 families of 32 nonreceptor, and 19 families of 58 receptor-connected TKs. Those TK families, which work in the ontogenesis of complex organs (ALK, anaplastic lymphoma kinase; EGF, epidermal growth factor; MET, hepatocyte growth factor receptor; RET, rearranged during transformation) are absent in the Nematostella. In contrast, the amphioxus possesses BRK and SRC (breast cancer; Rous sarcoma) non-receptor TK ancestors. Physiologically, BRK is involved in the fetal development of the pancreas and small intestine; SRC is a regulator of cell adhesions, motility and divisions.


Proliferate Cell Nuclear Antigen Adenomatous Polyposis Coli Anaplastic Lymphoma Kinase Synthetic Lethality Vide Supra 
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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.M.D. Anderson Hospital Comprehensive Cancer CenterThe University of TexasHoustonUSA
  2. 2.H.L. Moffitt Comprehensive Cancer CenterThe University of South FloridaTampaUSA
  3. 3.Department of Molecular MedicineThe University of South Florida Morsani College of MedicineTampaUSA
  4. 4.The Cancer InstituteSt. Joseph’s HospitalTampaUSA

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