Inbuilt Errors Not Yet Corrected
The invasion of the tyrosine kinases can go out of control. The human genome operates 10 families of 32 nonreceptor, and 19 families of 58 receptor-connected TKs. Those TK families, which work in the ontogenesis of complex organs (ALK, anaplastic lymphoma kinase; EGF, epidermal growth factor; MET, hepatocyte growth factor receptor; RET, rearranged during transformation) are absent in the Nematostella. In contrast, the amphioxus possesses BRK and SRC (breast cancer; Rous sarcoma) non-receptor TK ancestors. Physiologically, BRK is involved in the fetal development of the pancreas and small intestine; SRC is a regulator of cell adhesions, motility and divisions.