Skip to main content

Biliary Manifestations of Chronic Pancreatitis

  • Chapter
  • 817 Accesses

Abstract

Common bile duct stenosis (CBDS) is a frequent local complication of chronic pancreatitis (CP) owing to compression of the common bile duct by an inflammatory mass. While endoscopic treatment is effective in the initial management of CBDS in CP and is indicated in patients with severe cholangitis, there is ample evidence that the long-term results of endoscopic treatment are poor if the CBDS has not resolved within 12 months or if parenchymal calcifications are present. Surgical therapy of CBDS in chronic pancreatitis is effective and associated with good long-term results. Surgical therapy should not only address the CBDS but also the underlying CP, especially a frequently coexisting stenosis of the pancreatic duct. Surgical options include drainage operations as well as pancreatoduodenectomy, duodenum preserving pancreatic head resection, and, in rare cases, total pancreatectomy. In patients with an inflammatory mass in the head of the pancreas a resection procedure should be performed.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Abdallah AA, Krige JE, Bornman PC. Biliary tract obstruction in chronic pancreatitis. HPB. 2007;9(6):421–8.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Beger HG, Buchler M, Bittner R. The duodenum preserving resection of the head of the pancreas (DPRHP) in patients with chronic pancreatitis and an inflammatory mass in the head. An alternative surgical technique to the Whipple operation. Acta Chir Scand. 1990;156(4):309–15.

    PubMed  CAS  Google Scholar 

  3. Beger HG, Schlosser W, Friess HM, et al. Duodenum-preserving head resection in chronic pancreatitis changes the natural course of the disease: a single-center 26-year experience. Ann Surg. 1999;230(4):512–9.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  4. Keck T, Marjanovic G, Fernandez-del Castillo C, et al. The inflammatory pancreatic head mass: significant differences in the anatomic pathology of German and American patients with chronic pancreatitis determine very different surgical strategies. Ann Surg. 2009;249(1):105–10.

    Article  PubMed  Google Scholar 

  5. Koninger J, Seiler CM, Sauerland S, et al. Duodenum-preserving pancreatic head resection—a randomized controlled trial comparing the original Beger procedure with the Berne modification (ISRCTN No. 50638764). Surgery. 2008;143(4):490–8.

    Article  PubMed  Google Scholar 

  6. Farkas G, Leindler L, Daroczi M, et al. Organ-preserving pancreatic head resection in chronic pancreatitis. Br J Surg. 2003;90(1):29–32.

    Article  PubMed  CAS  Google Scholar 

  7. Strobel O, Buchler MW, Werner J. Surgical therapy of chronic pancreatitis: indications, techniques and results. Int J Surg. 2009;7(4):305–12.

    Article  PubMed  Google Scholar 

  8. Forsmark CE. Management of chronic pancreatitis. Gastroenterology. 2013;144(6):1282–91. e3.

    Article  PubMed  Google Scholar 

  9. Frey CF, Suzuki M, Isaji S. Treatment of chronic pancreatitis complicated by obstruction of the common bile duct or duodenum. World J Surg. 1990;14(1):59–69.

    Article  PubMed  CAS  Google Scholar 

  10. Hammel P, Couvelard A, O'Toole D, et al. Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct. N Engl J Med. 2001;344(6):418–23.

    Article  PubMed  CAS  Google Scholar 

  11. Rosch T, Daniel S, Scholz M, et al. Endoscopic treatment of chronic pancreatitis: a multicenter study of 1000 patients with long-term follow-up. Endoscopy. 2002;34(10):765–71.

    Article  PubMed  CAS  Google Scholar 

  12. Cahen DL, van Berkel AM, Oskam D, et al. Long-term results of endoscopic drainage of common bile duct strictures in chronic pancreatitis. Eur J Gastroenterol Hepatol. 2005;17(1):103–8.

    Article  PubMed  Google Scholar 

  13. Kahl S, Zimmermann S, Genz I, et al. Risk factors for failure of endoscopic stenting of biliary strictures in chronic pancreatitis: a prospective follow-up study. Am J Gastroenterol. 2003;98(11):2448–53.

    Article  PubMed  Google Scholar 

  14. Johnson MD, Walsh RM, Henderson JM, et al. Surgical versus nonsurgical management of pancreatic pseudocysts. J Clin Gastroenterol. 2008;43(6):586–90.

    Article  Google Scholar 

  15. Dite P, Ruzicka M, Zboril V, et al. A prospective, randomized trial comparing endoscopic and surgical therapy for chronic pancreatitis. Endoscopy. 2003;35(7):553–8.

    Article  PubMed  CAS  Google Scholar 

  16. Cahen DL, Gouma DJ, Nio Y, et al. Endoscopic versus surgical drainage of the pancreatic duct in chronic pancreatitis. N Engl J Med. 2007;356(7):676–84.

    Article  PubMed  CAS  Google Scholar 

  17. Regimbeau JM, Fuks D, Bartoli E, et al. A comparative study of surgery and endoscopy for the treatment of bile duct stricture in patients with chronic pancreatitis. Surg Endosc. 2012;26(10):2902–8.

    Article  PubMed  Google Scholar 

  18. Rebibo L, Yzet T, Cosse C, et al. Frey procedure for the treatment of chronic pancreatitis associated with common bile duct stricture. Hepatobiliary Pancreat Dis Int. 2013;12(6):637–44.

    Article  PubMed  Google Scholar 

  19. Whipple AO. An evaluation of radical surgery for carcinoma of the pancreas and ampullary region. Ann Intern Med. 1949;31(4):624–7.

    Article  PubMed  CAS  Google Scholar 

  20. Traverso LW, Kozarek RA. The Whipple procedure for severe complications of chronic pancreatitis. Arch Surg. 1993;128(9):1047–50.

    Article  PubMed  CAS  Google Scholar 

  21. Traverso LW. The pylorus preserving Whipple procedure for the treatment of chronic pancreatitis. Swiss Surg. 2000;6(5):259–63.

    Article  PubMed  CAS  Google Scholar 

  22. Jimenez RE, Fernandez-del Castillo C, Rattner DW, et al. Outcome of pancreaticoduodenectomy with pylorus preservation or with antrectomy in the treatment of chronic pancreatitis. Ann Surg. 2000;231(3):293–300.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  23. Jimenez RE, Fernandez-del Castillo C, Rattner DW, et al. Pylorus-preserving pancreaticoduodenectomy in the treatment of chronic pancreatitis. World J Surg. 2003;27(11):1211–6.

    Article  PubMed  Google Scholar 

  24. Buchler MW, Warshaw AL. Resection versus drainage in treatment of chronic pancreatitis. Gastroenterology. 2008;134(5):1605–7.

    Article  PubMed  Google Scholar 

  25. Beger HG, Witte C, Krautzberger W, et al. Experiences with duodenum-sparing pancreas head resection in chronic pancreatitis. Chirurg. 1980;51(5):303–7.

    PubMed  CAS  Google Scholar 

  26. Beger HG, Krautzberger W, Bittner R, et al. Duodenum-preserving resection of the head of the pancreas in patients with severe chronic pancreatitis. Surgery. 1985;97(4):467–73.

    PubMed  CAS  Google Scholar 

  27. Izbicki JR, Bloechle C, Broering DC, et al. Reinsertion of the distal common bile duct into the resection cavity during duodenum-preserving resection of the head of the pancreas for chronic pancreatitis. Br J Surg. 1997;84(6):791–2.

    Article  PubMed  CAS  Google Scholar 

  28. Frey CF, Amikura K. Local resection of the head of the pancreas combined with longitudinal pancreaticojejunostomy in the management of patients with chronic pancreatitis. Ann Surg. 1994;220(4):492–504.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  29. Frey CF, Bodai BI. Surgery in chronic pancreatitis. Clin Gastroenterol. 1984;13(3):913–40.

    PubMed  CAS  Google Scholar 

  30. Frey CF, Smith GJ. Description and rationale of a new operation for chronic pancreatitis. Pancreas. 1987;2(6):701–7.

    Article  PubMed  CAS  Google Scholar 

  31. Gloor B, Friess H, Uhl W, et al. A modified technique of the Beger and Frey procedure in patients with chronic pancreatitis. Dig Surg. 2001;18(1):21–5.

    Article  PubMed  CAS  Google Scholar 

  32. Muller MW, Friess H, Martin DJ, et al. Long-term follow-up of a randomized clinical trial comparing Beger with pylorus-preserving Whipple procedure for chronic pancreatitis. Br J Surg. 2008;95(3):350–6.

    Article  PubMed  CAS  Google Scholar 

  33. Buchler MW, Friess H, Bittner R, et al. Duodenum-preserving pancreatic head resection: long-term results. J Gastrointest Surg. 1997;1(1):13–9.

    Article  PubMed  CAS  Google Scholar 

  34. Buchler MW, Friess H, Muller MW, et al. Randomized trial of duodenum-preserving pancreatic head resection versus pylorus-preserving Whipple in chronic pancreatitis. Am J Surg. 1995;169(1):65–9.

    Article  PubMed  CAS  Google Scholar 

  35. Izbicki JR, Bloechle C, Broering DC, et al. Extended drainage versus resection in surgery for chronic pancreatitis: a prospective randomized trial comparing the longitudinal pancreaticojejunostomy combined with local pancreatic head excision with the pylorus-preserving pancreatoduodenectomy. Ann Surg. 1998;228(6):771–9.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  36. Izbicki JR, Bloechle C, Knoefel WT, et al. Duodenum-preserving resection of the head of the pancreas in chronic pancreatitis. A prospective, randomized trial. Ann Surg. 1995;221(4):350–8.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  37. Klempa I, Spatny M, Menzel J, et al. Pancreatic function and quality of life after resection of the head of the pancreas in chronic pancreatitis. A prospective, randomized comparative study after duodenum preserving resection of the head of the pancreas versus Whipple's operation. Chirurg. 1995;66(4):350–9.

    PubMed  CAS  Google Scholar 

  38. Morgan K, Owczarski SM, Borckardt J, et al. Pain control and quality of life after pancreatectomy with islet autotransplantation for chronic pancreatitis. J Gastrointest Surg. 2012;16(1):129–33. discussion 133–4.

    Article  PubMed  Google Scholar 

  39. Muller MW, Friess H, Beger HG, et al. Gastric emptying following pylorus-preserving Whipple and duodenum-preserving pancreatic head resection in patients with chronic pancreatitis. Am J Surg. 1997;173(4):257–63.

    Article  PubMed  CAS  Google Scholar 

  40. Strate T, Bachmann K, Busch P, et al. Resection vs drainage in treatment of chronic pancreatitis: long-term results of a randomized trial. Gastroenterology. 2008;134(5):1406–11.

    Article  PubMed  Google Scholar 

  41. Strate T, Taherpour Z, Bloechle C, et al. Long-term follow-up of a randomized trial comparing the beger and Frey procedures for patients suffering from chronic pancreatitis. Ann Surg. 2005;241(4):591–8.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Diener MK, Rahbari NN, Fischer L, et al. Duodenum-preserving pancreatic head resection versus pancreatoduodenectomy for surgical treatment of chronic pancreatitis: a systematic review and meta-analysis. Ann Surg. 2008;247(6):950–61.

    Article  PubMed  Google Scholar 

  43. Bellin MD, Freeman ML, Gelrud A, et al. Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest. Pancreatology. 2014;14(1):27–35.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Morgan KA, Theruvath T, Owczarski S, et al. Total pancreatectomy with islet autotransplantation for chronic pancreatitis: do patients with prior pancreatic surgery have different outcomes? Am Surg. 2012;78(8):893–6.

    PubMed  Google Scholar 

  45. Sutherland DE, Radosevich DM, Bellin MD, et al. Total pancreatectomy and islet autotransplantation for chronic pancreatitis. J Am Coll Surg. 2012;214(4):409–24. discussion 424–6.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Kersting S, Janot MS, Chromik AM, et al. Contemporary single-center surgical experiences in redo procedures of the pancreas: improved outcome and reduction of operative risk. J Gastrointest Surg. 2011;15(1):191–8.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Markus W. Büchler M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Strobel, O., Contin, P., Büchler, M.W. (2015). Biliary Manifestations of Chronic Pancreatitis. In: Dixon, E., Vollmer Jr., C., May, G. (eds) Management of Benign Biliary Stenosis and Injury. Springer, Cham. https://doi.org/10.1007/978-3-319-22273-8_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-22273-8_4

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-22272-1

  • Online ISBN: 978-3-319-22273-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics