Aggressive Behavior

  • Hesham Yousry Elnazer
  • Niruj AgrawalEmail author
Part of the Neuropsychiatric Symptoms of Neurological Disease book series (NSND)


Epilepsy was considered to be commonly associated with aggression historically. It has also been emphasized in medicolegal settings. However, the link between epilepsy and directed aggression is now noted to be less clear-cut even though brief and non-directed aggression can occur not so uncommonly. Aggression in epilepsy could be linked to a number of factors including seizures or the underlying electrophysiological activity of the brain, neuropsychiatric comorbidities, antiepileptic drugs or underlying brain damage which may cause aggression and epilepsy both. Common clinical presentations of aggressive behaviors in epilepsy and their pathogenesis are discussed. A clinical approach to assess and manage these problems is described and related evidence is discussed.


Epilepsy Aggression Agitation Automatism Intermittent Explosive Disorder 


  1. 1.
    Saraceno B, Avanzini G, Lee P, editors. Atlas: epilepsy care in the world. World Health Organization; 2005. Retrieved 20 Dec 2013.
  2. 2.
    Magiorkinis E, Kalliopi S, Diamantis A. Hallmarks in the history of epilepsy: epilepsy in antiquity. Epilepsy Behav. 2010;17(1):103–8.CrossRefPubMedGoogle Scholar
  3. 3.
    Epilepsy: an historical overview. World Health Organization; 2001. Retrieved 27 Dec 2013. htpp://
  4. 4.
    Lombroso-Ferrero G. Criminal man according to the classification of Cesare Lombroso. Montclair: Patterson Smith; 1972.Google Scholar
  5. 5.
    Kolb LC, Brodie HKH. Modern clinical psychiatry. 10th ed. Philadelphia: WB Saunders; 1982.Google Scholar
  6. 6.
    Pincus J. Violence and epilepsy. N Engl J Med. 1981;305:696–8.CrossRefPubMedGoogle Scholar
  7. 7.
    Delgado-Escueta AV, Mattson RH, King L, Goldensohn ES, Spiegel H, Madsen J, et al. Special report: the nature of aggression during epileptic seizures. N Engl J Med. 1981;305:711–6.CrossRefPubMedGoogle Scholar
  8. 8.
    Treiman DM. Psychobiology of ictal aggression. In: Smith D, Treiman DM, Trimble M, editors. Neurobehavioral problems in epilepsy. New York: Raven; 1991. p. 341–56.Google Scholar
  9. 9.
    Hauser WA. Incidence and prevalence. In: Engel J, Pedley TA, editors. Epilepsy: a comprehensive textbook. Philadelphia: Lippincott-Raven; 1997. p. 47–57.Google Scholar
  10. 10.
    Hermann BP, Whitman S. Behavioural and personality correlates of epilepsy: a review methodological critique, and conceptual model. Psychol Bull. 1984;95:451–92.CrossRefPubMedGoogle Scholar
  11. 11.
    Engel Jr J. Update on surgical treatment of the epilepsies. Summary of the second international palm desert conference on the surgical treatment of the epilepsies (1992). Neurology. 1993;43(8):1612–7.CrossRefPubMedGoogle Scholar
  12. 12.
    Piazzini A, Bravi F, Edefonti V, Turner K, Vignoli A, Ferraroni M, Canevini MP. Aggressive behavior and epilepsy: a multicenter study. Epilepsia. 2012;53(10):e174–9.CrossRefPubMedGoogle Scholar
  13. 13.
    Bogdanovic MD, Mead SH, Duncan JS. Aggressive behaviour at a residential epilepsy centre. Seizure. 2000;9(1):58–64.CrossRefPubMedGoogle Scholar
  14. 14.
    Treiman DM. Epilepsy and violence: medical and legal issues. Epilepsia. 1986;27 Suppl 2:S77–104.CrossRefPubMedGoogle Scholar
  15. 15.
    Ito M. Neuropsychiatric evaluations of postictal behavioral changes. Epilepsy Behav. 2010;19(2):134–7.CrossRefPubMedGoogle Scholar
  16. 16.
    Blanchet P, Frommer GP. Mood change preceding epileptic seizures. J Nerv Ment Dis. 1986;174(8):471–6.CrossRefPubMedGoogle Scholar
  17. 17.
    Bronsard G, Bartolomei F. Rhythms, rhythmicity and aggression. J Physiol Paris. 2013;107(4):327–34.CrossRefPubMedGoogle Scholar
  18. 18.
    Manchanda R, Freeland A, Schaefer B, McLachlan RS, Blume WT. Auras, seizure focus, and psychiatric disorders. Neuropsychiatry Neuropsychol Behav Neurol. 2000;13(1):13–9.PubMedGoogle Scholar
  19. 19.
    Biraben A, Taussig D, Thomas P, Even C, Vignal J, Scarabin J, Chauvel P. Fear as the main feature of epileptic seizures. J Neurol Neurosurg Psychiatry. 2001;70(2):186–91.PubMedCentralCrossRefPubMedGoogle Scholar
  20. 20.
    Alemayehu S, Bergey GK, Barry E, Krumholz A, Wolf A, Fleming CP, Frear Jr EJ. Panic attacks as ictal manifestations of parietal lobe seizures. Epilepsia. 1995;36(8):824–30.CrossRefPubMedGoogle Scholar
  21. 21.
    Kanemoto K, Kawasaki J, Mori E. Violence and epilepsy: a close relation between violence and postictal psychosis. Epilepsia. 1999;40(1):107–9.CrossRefPubMedGoogle Scholar
  22. 22.
    Treiman DM. Violence and the epilepsy defense. Neurol Clin. 1999;17(2):245–55.CrossRefPubMedGoogle Scholar
  23. 23.
    Kanner AM. Recognition of the various expressions of anxiety, psychosis and aggression in epilepsy. Epilepsia. 2004;45 Suppl 2:22–7.CrossRefPubMedGoogle Scholar
  24. 24.
    Kanner AM, Stagno S, Kotagal P. Postictal psychiatric events during prolonged video-electroencephalographic monitoring studies. Arch Neurol. 1996;53(3):258–63.CrossRefPubMedGoogle Scholar
  25. 25.
    So NK, Savard G, Andermann F, Olivier A, Quesney LF. Acute postictal psychosis: a stereo EEG study. Epilepsia. 1990;31(2):188–93.CrossRefPubMedGoogle Scholar
  26. 26.
    Kanner AM, Trimble M, Schmitz B. Postictal affective episodes. Epilepsy Behav. 2010;19(2):156–8.CrossRefPubMedGoogle Scholar
  27. 27.
    Hamed SA. Psychiatric symptomatologies and disorders related to epilepsy and antiepileptic medications. Expert Opin Drug Saf. 2011;10(6):913–34.CrossRefPubMedGoogle Scholar
  28. 28.
    Devinsky O. Interictal behavioral changes in epilepsy. In: Devinsky O, Theodore WH, editors. Epilepsy and behavior. New York: Wiley–Liss; 1991. p. 1–21.Google Scholar
  29. 29.
    Bear DM, Fedio P. Quantitative analysis of interictal behavior in temporal lobe epilepsy. Arch Neurol. 1977;34:454–67.CrossRefPubMedGoogle Scholar
  30. 30.
    Wieser HG, Hailemariam S, Regard M. Unilateral limbic epileptic status activity: stereo-EEG, behavioral, and cognitive data. Epilepsia. 1985;26:19–29.CrossRefPubMedGoogle Scholar
  31. 31.
    van Elst LT, Woermann FG, Lemieux L, Thompson PJ, Trimble MR. Affective aggression in patients with temporal lobe epilepsy, a quantitative MRI study of the amygdala. Brain. 2000;123(Pt 2):234–43.CrossRefPubMedGoogle Scholar
  32. 32.
    Engel J, Wilson C, Lopez-Rodriguez F. Limbic connectivity: anatomical substrates of behavioural disturbances in epilepsy. In: Trimble M, Schmitz B, editors. The neuropsychiatry of epilepsy. Cambridge: Cambridge University Press; 2002. p. 18–37.CrossRefGoogle Scholar
  33. 33.
    Mula M, Marotta AE, Monaco F. Epilepsy and bipolar disorders. Expert Rev Neurother. 2010;10(1):13–23.CrossRefPubMedGoogle Scholar
  34. 34.
    Drevets WC. Functional neuroimaging studies of depression: the anatomy of melancholia. Annu Rev Med. 1998;49:341–61.CrossRefPubMedGoogle Scholar
  35. 35.
    Hamed SA. Neuronal plasticity: implications in epilepsy progression and management. Drug Dev Res. 2007;68(8):498–511.CrossRefGoogle Scholar
  36. 36.
    Engel J, Shewmon DA. Impact of the kindling phenomenon on clinical epileptology. In: Morrell F, editor. Kindling and synaptic plasticity: the legacy of Graham Goddard. Cambridge: Birkhauser; 1991. p. 195–210.Google Scholar
  37. 37.
    Steriade M. Corticothalamic resonance, states of vigilance and mentation. Neuroscience. 2000;101(2):243–76.CrossRefPubMedGoogle Scholar
  38. 38.
    Keele NB. The role of serotonin in impulsive and aggressive behaviors associated with epilepsy-like neuronal hyperexcitability in the amygdala. Epilepsy Behav. 2005;7(3):325–35.CrossRefPubMedGoogle Scholar
  39. 39.
    Mahanty NK, Sah P. Excitatory synaptic inputs to pyramidal neurons of the lateral amygdala. Eur J Neurosci. 1999;11:1217–22.CrossRefPubMedGoogle Scholar
  40. 40.
    Rainnie DG, Asprodini EK, Shinnick-Gallagher P. Excitatory transmission in the basolateral amygdala. J Neurophysiol. 1991;66:986–98.PubMedGoogle Scholar
  41. 41.
    Rainnie DG, Asprodini EK, Shinnick-Gallagher P. Inhibitory transmission in the basolateral amygdala. J Neurophysiol. 1991;66:999–1009.PubMedGoogle Scholar
  42. 42.
    McKernan MG, Shinnick-Gallagher P. Fear conditioning induces a lasting potentiation of synaptic currents in vitro. Nature. 1997;390:607–11.CrossRefPubMedGoogle Scholar
  43. 43.
    Huang CC, Hsu KS, Gean PW. Isoproterenol potentiates synaptic transmission primarily by enhancing presynaptic calcium influx via P- and/or Q-type calcium channels in the rat amygdala. J Neurosci. 1996;16:1026–33.PubMedGoogle Scholar
  44. 44.
    Gean P-W, Chang F-C, Huang C-C, Lin J-H, Long-Joy W, et al. Longterm enhancement of EPSP and NMDA receptor-mediated synaptic transmission in the amygdala. Brain Res Bull. 1993;31:7–11.CrossRefPubMedGoogle Scholar
  45. 45.
    Wang SJ, Gean PW. Long-term depression of excitatory synaptic transmission in the rat amygdala. J Neurosci. 1999;19:10656–63.PubMedGoogle Scholar
  46. 46.
    Asprodini EK, Rainnie DG, Shinnick-Gallagher P. Epileptogenesis reduces the sensitivity of presynaptic gamma-aminobutyric acid B receptors on glutamatergic afferents in the amygdala. J Pharmacol Exp Ther. 1992;262:1011–21.PubMedGoogle Scholar
  47. 47.
    Shinnick-Gallagher P, Keele NB, Neugebauer V. Long-lasting changes in the pharmacology and electrophysiology of amino acid receptors in amygdala kindled neurons. In: Corcoran M, Moshe S, editors. Kindling 5. New York: Plenum; 1997.Google Scholar
  48. 48.
    Rogan MT, Staubli UV, LeDoux JE. Fear conditioning induces associative long-term potentiation in the amygdala. Nature. 1997;390:604–7.CrossRefPubMedGoogle Scholar
  49. 49.
    Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol. 1972;32:281–94.CrossRefPubMedGoogle Scholar
  50. 50.
    Fenwick P. Aggression and epilepsy. In: Devinsky O, Theodore WH, editors. Epilepsy and behavior. New York: Wiley–Liss; 1991. p. 85–96.Google Scholar
  51. 51.
    Mark VH, Ervin FR. Violence and the brain. New York: Harper & Row; 1970.Google Scholar
  52. 52.
    Broicher S, Kuchukhidze G, Grunwald T, Krämer G, Kurthen M, Trinka E, Joiket H. Association between structural abnormalities and fMRI response in the amygdala in patients with temporal lobe epilepsy. Seizure. 2010;19(7):426–31.CrossRefPubMedGoogle Scholar
  53. 53.
    Helmstaedter C. Behavioral aspects of frontal lobe epilepsy. Epilepsy Behav. 2001;2(5):384–95.CrossRefPubMedGoogle Scholar
  54. 54.
    Elst LT, Groffmann M, Ebert D, Schulze-Bonhage A. Amygdala volume loss in patients with dysphoric disorder of epilepsy. Epilepsy Behav. 2009;16(1):105–12.CrossRefPubMedGoogle Scholar
  55. 55.
    Eron LD, Gruder CL. Some topics closely related to the study of abnormal behavior: aggression and fantasy. In: Reiss S et al., editors. Abnormality: experimental and clinical approaches. New York: Macmillan; 1977. p. 579–638.Google Scholar
  56. 56.
    Ketter TA, Post RM, Theodore WH. Positive and negative psychiatric effects of antiepileptic drugs in patients with seizure disorders. Neurology. 1999;53 Suppl 2:S53–67.PubMedGoogle Scholar
  57. 57.
    Nadkarni S, Devinsky O. Psychotropic effects of antiepileptic drugs. Epilepsy Curr. 2005;5(5):176–81.PubMedCentralCrossRefPubMedGoogle Scholar
  58. 58.
    Koneski JA, Casella EB. Attention deficit and hyperactivity disorder in people with epilepsy: diagnosis and implications to the treatment. Arq Neuropsiquiatr. 2010;68(1):107–14.CrossRefPubMedGoogle Scholar
  59. 59.
    Kuzniecky R, Ho S, Pan J. Modulation of cerebral GABA By topiramate, lamotrigine, and gabapentin in healthy adults. Neurology. 2002;58(3):368–72.CrossRefPubMedGoogle Scholar
  60. 60.
    Yanai J, Fares F, Gavish M, Greenfeld Z, Katz Y, Marcovici G, et al. Neural and behavioral alterations after early exposure to phenobarbital. Neurotoxicology. 1989;10(3):543–54.PubMedGoogle Scholar
  61. 61.
    Meador KJ, Loring DW, Hulihan JF, Kamin M, CAPSS-027 Study Group, Karim R. Differential cognitive and behavioural effects of topiramate and valproate. Neurology. 2003;40(9):1279–85.Google Scholar
  62. 62.
    Harden CL, Lazar LM, Pick LH, Nikolov B, Goldstein MA, Carson D, et al. A beneficial effect on mood in partial epilepsy patients treated with gabapentin. Epilepsia. 1999;40(8):1129–34.CrossRefPubMedGoogle Scholar
  63. 63.
    McConnell H, Snyder PJ, Duffy JD, Weilburg J, Valeriano J, Brillman J, et al. Neuropsychiatric side effects related to felbamate. J Neuropsychiatry Clin Neurosci. 1996;8(3):341–6.CrossRefPubMedGoogle Scholar
  64. 64.
    Fakhoury TA, Miller JM, Hammer AE, Vuong A. Effects of lamotrigine on mood in older adults with epilepsy and co-morbid depressive symptoms: an open-label, multicentre, prospective study. Drugs Aging. 2008;25(11):955–62.CrossRefPubMedGoogle Scholar
  65. 65.
    Cavanna AE, Ali F, Rickards HE, McCorry D. Behavioral and cognitive effects of anti-epileptic drugs. Discov Med. 2010;9(45):138–44.PubMedGoogle Scholar
  66. 66.
    Gardner DL, Cowdry RW. Positive effects of carbamazepine on behavioral dyscontrol in borderline personality disorder. Am J Psychiatry. 1986;143:519–22.CrossRefPubMedGoogle Scholar
  67. 67.
    Kavoussi RJ, Coccaro EF. Divalproex sodium for impulsive aggressive behavior in patients with personality disorder behavior in patients with personality disorder. J Clin Psychiatry. 1998;59:676–80.CrossRefPubMedGoogle Scholar
  68. 68.
    Wolf P, Trimble MR. Biological antagonism and epileptic psychosis. Br J Psychiatry. 1985;146:272–6.CrossRefPubMedGoogle Scholar
  69. 69.
    Cramer JA, De Rue K, Devinsky O, Edrich P, Trimble MR. A systematic review of the behavioral effects of levetiracetam in adults with epilepsy, cognitive disorders, or an anxiety disorder during clinical trials. Epilepsy Behav. 2003;4(2):124–32.CrossRefPubMedGoogle Scholar
  70. 70.
    Mecarelli O, Vicenzini E, Pulitano P, Vanacore N, Romolo FS, Di Piero V, et al. Clinical, cognitive and neurophysiologic correlates of short-term treatment with carbamazepine, oxcarbazepine and levetiracetam in healthy volunteer. Ann Pharmacother. 2004;38(11):1816–22.CrossRefPubMedGoogle Scholar
  71. 71.
    Helmstaedter C, Fritz NE, Kockelmann E, Kosanetzky N, Elger CE. Positive and negative psychotropic effects of levetiracetam. Epilepsy Behav. 2008;13(3):535–41.CrossRefPubMedGoogle Scholar
  72. 72.
    Mula M, Agrawal N, Mustafa Z, Mohanalingham K, Cock HR, Lozsadi DA, von Oertzen TJ. Self-reported aggressiveness during treatment with levetiracetam correlates with depression. Epilepsy Behav. 2015;45:64–7.Google Scholar
  73. 73.
    de la Loge C, Hunter SJ, Schiemann J, Yang H. Assessment of behavioral and emotional functioning using standardized instruments in children and adolescents with partial-onset seizures treated with adjunctive levetiracetam in a randomized, placebo-controlled trial. Epilepsy Behav. 2010;18(3):291–8.CrossRefPubMedGoogle Scholar
  74. 74.
    Belcastro V, Costa C, Galletti F, Autuori A, Pierguidi L, Pisani F, et al. Levetiracetam in newly diagnosed late-onset post-stroke seizures: a prospective observational study. Epilepsy Res. 2008;82(2–3):223–6.CrossRefPubMedGoogle Scholar
  75. 75.
    Opp J, Tuxhorn I, May T, Klugerc G, Wiemer-Krueld A, Kurlemanne G, et al. Levetiracetam in children with refractory epilepsy: a multicenter open label study in Germany. Seizure. 2005;14(7):476–84.CrossRefPubMedGoogle Scholar
  76. 76.
    Schiemann-Delgado J, Yang H, Loge Cde L, Stalvey TJ, Jones J, Legoff D, Mintz M. A long-term open-label extension study assessing cognition and behavior, tolerability, safety, and efficacy of adjunctive levetiracetam in children aged 4 to 16 years with partial-onset seizures. J Child Neurol. 2012;27(1):80–9.CrossRefPubMedGoogle Scholar
  77. 77.
    Rugg-Gunn F. Adverse effects and safety profile of perampanel: a review of pooled data. Epilepsia. 2014;55 Suppl 1:13–5. doi: 10.1111/epi.12504.CrossRefPubMedGoogle Scholar
  78. 78.
    Ettinger A, Reed M, Cramer J. Depression and comorbidity in community-based patients with epilepsy or asthma. Neurology. 2004;63(6):1008–14.CrossRefPubMedGoogle Scholar
  79. 79.
    Mensah SA, Beavis JM, Thapar AK. The presence and clinical implications of depression in a community population of adults with epilepsy. Epilepsy Behav. 2006;8(1):213–9.CrossRefPubMedGoogle Scholar
  80. 80.
    Riggio S. Traumatic brain injury and its neurobehavioral sequelae. Psychiatr Clin North Am. 2010;33(4):807–19.CrossRefPubMedGoogle Scholar
  81. 81.
    Beyenburg S, Mitchell AJ, Schmidt D, Elger CE, Reuber M. Anxiety in patients with epilepsy: systematic review and suggestions for clinical management. Epilepsy Behav. 2005;7(2):161–71.CrossRefPubMedGoogle Scholar
  82. 82.
    Brower MC, Price BH. Epilepsy and violence: when is the brain to blame? Epilepsy Behav. 2000;1:145–9.CrossRefPubMedGoogle Scholar
  83. 83.
    Kanemoto K. Periictal Capgras syndrome following clustered ictal fear. Epilepsia. 1997;38:847–50.CrossRefPubMedGoogle Scholar
  84. 84.
    Hermann BP, Chhabria S. Interictal psychopathology in patients with ictal fear: examples of sensory-limbic hyperconnection? Arch Neurol. 1980;37:667–8.CrossRefPubMedGoogle Scholar
  85. 85.
    Takeda Y, Inoue Y, Tottori T, Mihara T. Acute psychosis during intracranial EEG monitoring: close relationship between psychotic symptoms and discharges in amygdala. Epilepsia. 2001;42:719–24.CrossRefPubMedGoogle Scholar
  86. 86.
    Kanemoto K, Tadokoro Y, Oshima T. Violence and postictal psychosis: a comparison of postictal psychosis, interictal psychosis, and postictal confusion. Epilepsy Behav. 2010;19(2):162–6.CrossRefPubMedGoogle Scholar
  87. 87.
    Monroe R. Episodic behaviour disorder. Boston: Harvard University Press; 1970.Google Scholar
  88. 88.
    Mrabet H, Mrabet A, Zouari B, Ghachem R. Health-related quality of life of people with epilepsy compared with a general reference population: a Tunisian study. Epilepsia. 2004;45(7):838–43.CrossRefPubMedGoogle Scholar
  89. 89.
    Leppik IE, Gram L, Deaton R, Sommerville KW. Safety of tiagabine: summary of 53 trials. Epilepsy Res. 1999;33(2–3):235–46.CrossRefPubMedGoogle Scholar
  90. 90.
    Trimble M. Treatment issues for personality disorders in epilepsy. Epilepsia. 2013;54 Suppl 1:41–5.CrossRefPubMedGoogle Scholar
  91. 91.
    Harvey AT, Preskorn SH. Cytochrome P450 enzymes: interpretation of their interactions with selective serotonin reuptake inhibitors (part 1). J Clin Psychopharmacol. 1996;16(4):273–85.CrossRefPubMedGoogle Scholar
  92. 92.
    Dursun SM, Mathew VM, Reveley MA. Toxic serotonin syndrome after fluoxetine plus carbamazepine. Lancet. 1993;342(8868):442–3.CrossRefPubMedGoogle Scholar
  93. 93.
    Grimsley SR, Jann MW, Carter JG, D’Mello AP, D’Souza MJ. Increased carbamazepine plasma concentrations after fluoxetine coadministration. Clin Pharmacol Ther. 1991;50(1):10–5.CrossRefPubMedGoogle Scholar
  94. 94.
    Lucena MI, Blanco E, Corrales MA, Berthier ML. Interaction of fluoxetine and valproic acid. Am J Psychiatry. 1998;155(4):575.CrossRefPubMedGoogle Scholar
  95. 95.
    McConnell H, Duncan D. Treatment of psychiatric comorbidity in epilepsy. In: McConnell H, Snyder PJ, editors. Psychiatric comorbidity in epilepsy: basic mechanisms, diagnosis, and treatment. Washington, DC: American Psychiatric Press; 1998. p. 245–61.Google Scholar
  96. 96.
    Baghai TC, Moller HJ. Electroconvulsive therapy and its different indications. Dialogues Clin Neurosci. 2008;10(1):105–17.PubMedCentralPubMedGoogle Scholar
  97. 97.
    Elger G, Hoppe C, Falkai P, Rush AJ, Elgera CE. Vagus nerve stimulation is associated with mood improvements in epilepsy patients. Epilepsy Res. 2000;42(2–3):203–10.CrossRefPubMedGoogle Scholar
  98. 98.
    Ninan TN, Cole JO, Yonkers KA. Nonbenzodiazepine anxiolytics. In: Schatzberg AF, Nemeroff CB, editors. Textbook of psychopharmacology. 2nd ed. Washington, DC: American Psychiatric Press; 1998. p. 287–300.Google Scholar
  99. 99.
    Catalano G, Catalano MC, Hanley PF. Seizures associated with buspirone overdose: case report and literature review. Clin Neuropharmacol. 1998;21(6):347–50.PubMedGoogle Scholar
  100. 100.
    Yudofsky SC, Silver JM, Hales RE. Treatment of agitation and aggression. In: Yudofsky SC, Hales RE, editors. The American psychiatric press textbook of neuropsychiatry. Washington, DC: American Psychiatric Press; 1997. p. 881–900.Google Scholar
  101. 101.
    Raju SS, Gopalakrishna HN, Venkatadri N. Effect of propranolol and nifedipine on maximal electroshock-induced seizures in mice: individual and in combination. Pharmacol Res. 1998;38(6):449–52.CrossRefPubMedGoogle Scholar

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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of NeuropsychiatrySt. George’s HospitalLondonUK

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