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The Role of Stimulation Techniques

  • Steven C. SchachterEmail author
Part of the Neuropsychiatric Symptoms of Neurological Disease book series (NSND)

Abstract

Neuropsychiatric symptoms are common, under-recognized, and undertreated in patients with epilepsy (PWE), and have a profound impact on quality of life. Effective, safe, and well-tolerated treatments are urgently needed for patients whose neuropsychiatric symptoms do not respond to pharmacological or behavioral therapies. Some of the brain stimulation modalities that are effective for seizure control in patients with drug-resistant epilepsy may also be effective for neuropsychiatric symptoms of comorbid psychiatric disorders. This chapter first provides an overview of comorbid psychiatric disorders that have shown symptomatic improvement in brain stimulation studies. Next, the effects of different stimulation techniques on symptoms of these psychiatric disorders in PWE as well as in patients without epilepsy are reviewed. Limitations of our current understanding are then outlined with suggested directions for future research. The role of stimulation techniques in the care of PWE is only beginning to be understood and their potential application to the amelioration of neuropsychiatric symptoms in PWE should be actively pursued.

Keywords

Neurostimulation Epilepsy Depression Suicidality Anxiety Psychosis Closed-loop 

References

  1. 1.
    Cascino GD. When drugs and surgery don’t work. Epilepsia. 2008;49 Suppl 9:79–84.PubMedCrossRefGoogle Scholar
  2. 2.
    Tellez-Zenteno JF, Patten SB, Jette N, Williams J, Wiebe S. Psychiatric comorbidity in epilepsy: a population-based analysis. Epilepsia. 2007;48(12):2336–44.PubMedGoogle Scholar
  3. 3.
    Korczyn AD, Schachter SC, Brodie MJ, Dalal SS, Engel Jr J, Guekht A, et al. Epilepsy, cognition, and neuropsychiatry (epilepsy, brain and mind, part 2). Epilepsy Behav. 2013;28:283–302.PubMedCrossRefGoogle Scholar
  4. 4.
    Kanner AM. Depression in epilepsy: a complex relation with unexpected consequences. Curr Opin Neurol. 2008;21(2):190–4.PubMedCrossRefGoogle Scholar
  5. 5.
    Hesdorffer DC, Ishihara L, Mynepalli L, Webb DJ, Weil J, Hauser WA. Epilepsy, suicidality, and psychiatric disorders: a bidirectional association. Ann Neurol. 2012;72(2):184–91.PubMedCrossRefGoogle Scholar
  6. 6.
    Mendez MF, Cummings JL, Benson DF. Depression in epilepsy. Significance and phenomenology. Arch Neurol. 1986;43:766–70.PubMedCrossRefGoogle Scholar
  7. 7.
    O’Donoghue MF, Goodridge DM, Redhead K, Sander JW, Duncan JS. Assessing the psychosocial consequences of epilepsy: a community-based study. Br J Gen Pract. 1999;49:211–4.PubMedCentralPubMedGoogle Scholar
  8. 8.
    Kimiskidis VK, Triantafyllou NI, Kararizou E, Gatzonis SS, Fountoulakis KN, Siatouni A, et al. Depression and anxiety in epilepsy: the association with demographic and seizure-related variables. Ann Gen Psychiatr. 2007;6:28.CrossRefGoogle Scholar
  9. 9.
    Gilliam FG, Santos J, Vahle V, Carter J, Brown K, Hecimovic H. Depression in epilepsy: ignoring clinical expression of neuronal network dysfunction? Epilepsia. 2004;45 Suppl 2:28–33.PubMedCrossRefGoogle Scholar
  10. 10.
    Wiegartz P, Seidenberg M, Woodard A, Gidal B, Hermann B. Co-morbid psychiatric disorder in chronic epilepsy: recognition and etiology of depression. Neurology. 1999;53(5 Suppl 2):S3–8.PubMedGoogle Scholar
  11. 11.
    Kanner AM, Palac S. Depression in epilepsy: a common but often unrecognized comorbid malady. Epilepsy Behav. 2000;1(1):37–51.PubMedCrossRefGoogle Scholar
  12. 12.
    Kanner AM, Soto A, Gross-Kanner H. Prevalence and clinical characteristics of postictal psychiatric symptoms in partial epilepsy. Neurology. 2004;62(5):708–13.PubMedCrossRefGoogle Scholar
  13. 13.
    Blumer D, Montouris G, Davies K. The interictal dysphoric disorder: recognition, pathogenesis, and treatment of the major psychiatric disorder of epilepsy. Epilepsy Behav. 2004;5(6):826–40.PubMedCrossRefGoogle Scholar
  14. 14.
    Kanner AM, Kozak AM, Frey M. The use of sertraline in patients with epilepsy: is it safe? Epilepsy Behav. 2000;1(2):100–5.PubMedCrossRefGoogle Scholar
  15. 15.
    Blanchet P, Frommer GP. Mood change preceding epileptic seizures. J Nerv Ment Dis. 1986;174(8):471–6.PubMedCrossRefGoogle Scholar
  16. 16.
    Macrodimitris S, Sherman EM, Forde S, Tellez-Zenteno JF, Metcalfe A, Hernandez-Ronquillo L, et al. Psychiatric outcomes of epilepsy surgery: a systematic review. Epilepsia. 2011;52(5):880–90.PubMedCrossRefGoogle Scholar
  17. 17.
    Blumer D, Wakhlu S, Davies K, Hermann B. Psychiatric outcome of temporal lobectomy for epilepsy: incidence and treatment of psychiatric complications. Epilepsia. 1998;39(5):478–86.PubMedCrossRefGoogle Scholar
  18. 18.
    Landoldt H. Some clinical electroencephalographical correlations in epileptic psychosis (twilight states). Electroencephalogr Clin Neurophysiol. 1853;5:121.Google Scholar
  19. 19.
    Tellenbach H. Epilepsy as a convulsive disorder and as a psychosis, on alternative psychoses of paranoid nature in “forced normalization” (Landolt) of the electroencephalogram of epileptics. Nervenarzt. 1965;36:190–202.PubMedGoogle Scholar
  20. 20.
    Bell GS, Gaitatzis A, Bell CL, Johnson AL, Sander JW. Suicide in people with epilepsy: how great is the risk? Epilepsia. 2009;50:1933–42.PubMedCrossRefGoogle Scholar
  21. 21.
    Jones JE, Hermann BP, Barry JJ, Gilliam FG, Kanner AM, Meador KJ. Rates and risk factors for suicide, suicidal ideation, and suicide attempts in chronic epilepsy. Epilepsy Behav. 2003;4 Suppl 3:S31–8.PubMedCrossRefGoogle Scholar
  22. 22.
    Nilsson L, Ahlbom A, Farahmand BY, Asberg M, Tomson T. Risk factors for suicide in epilepsy: a case control study. Epilepsia. 2002;43(6):644–51.PubMedCrossRefGoogle Scholar
  23. 23.
    Kalinin VV, Polyanskiy DA. Gender differences in risk factors of suicidal behavior in epilepsy. Epilepsy Behav. 2005;6(3):424–9.PubMedCrossRefGoogle Scholar
  24. 24.
    U.S. Food and Drug Administration. Information for healthcare professionals: suicidality and antiepileptic drugs. Available at: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm100192.htm. Accessed 18 Jan 2015.
  25. 25.
    Mattsson P, Tibblin B, Kihlgren M, Kumlien E. A prospective study of anxiety with respect to seizure outcome after epilepsy surgery. Seizure. 2005;14(1):40–5.PubMedCrossRefGoogle Scholar
  26. 26.
    Goldstein MA, Harden CL. Epilepsy and anxiety. Epilepsy Behav. 2000;1(4):228–34.PubMedCrossRefGoogle Scholar
  27. 27.
    Pariente PD, Lepine JP, Lellouch J. Lifetime history of panic attacks and epilepsy: an association from a general population survey. J Clin Psychiatry. 1991;52(2):88–9.PubMedGoogle Scholar
  28. 28.
    Mintzer S, Lopez F. Comorbidity of ictal fear and panic disorder. Epilepsy Behav. 2002;3(4):330–7.PubMedCrossRefGoogle Scholar
  29. 29.
    de Oliveira GN, Kummer A, Salgado JV, Portela EJ, Sousa-Pereira SR, David AS, et al. Psychiatric disorders in temporal lobe epilepsy: an overview from a tertiary service in Brazil. Seizure. 2010;19(8):479–84.PubMedCrossRefGoogle Scholar
  30. 30.
    Monaco F, Cavanna A, Magli E, Barbagli D, Collimedaglia L, Cantello R, et al. Obsessionality, obsessive-compulsive disorder, and temporal lobe epilepsy. Epilepsy Behav. 2005;7(3):491–6.PubMedCrossRefGoogle Scholar
  31. 31.
    Ertekin BA, Kulaksizoglu IB, Ertekin E, Gurses C, Bebek N, Gokyiqit A, et al. A comparative study of obsessive-compulsive disorder and other psychiatric comorbidities in patients with temporal lobe epilepsy and idiopathic generalized epilepsy. Epilepsy Behav. 2009;14(4):634–9.PubMedCrossRefGoogle Scholar
  32. 32.
    Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62:593–602.PubMedCrossRefGoogle Scholar
  33. 33.
    Levin B, Duchowny M. Childhood obsessive-compulsive disorder and cingulate epilepsy. Biol Psychiatry. 1991;30(10):1049–55.PubMedCrossRefGoogle Scholar
  34. 34.
    Guarnieri R, Araujo D, Carlotti Jr CG, Assirati Jr JA, Hallak JE, Velasco TR, et al. Suppression of obsessive-compulsive symptoms after epilepsy surgery. Epilepsy Behav. 2005;7(2):316–9.PubMedCrossRefGoogle Scholar
  35. 35.
    Koopowitz LF, Berk M. Response of obsessive compulsive disorder to carbamazepine in two patients with comorbid epilepsy. Ann Clin Psychiatry. 1997;9(3):171–3.PubMedCrossRefGoogle Scholar
  36. 36.
    Kisely S, Hall K, Siskind D, Frater J, Olson S, Crompton D. Deep brain stimulation for obsessive-compulsive disorder: a systematic review and meta-analysis. Psychol Med. 2014;44:3533–42.PubMedCrossRefGoogle Scholar
  37. 37.
    Hamed SA, Elserogy YM, Abd-Elhafeez HA. Psychopathological and peripheral levels of neurobiological correlates of obsessive-compulsive symptoms in patients with epilepsy: a hospital-based study. Epilepsy Behav. 2013;27(2):409–15.PubMedCrossRefGoogle Scholar
  38. 38.
    Martin RC, Faught E, Richman J, Funkhouser E, Kim Y, Clements K, et al. Psychiatric and neurologic risk factors for incident cases of new-onset epilepsy in older adults: data from U.S. Medicare beneficiaries. Epilepsia. 2014;55(7):1120–7.PubMedCrossRefGoogle Scholar
  39. 39.
    Dikel TN, Fennell EB, Gilmore RL. Posttraumatic stress disorder, dissociation, and sexual abuse history in epileptic and nonepileptic seizure patients. Epilepsy Behav. 2003;4:644–50.PubMedCrossRefGoogle Scholar
  40. 40.
    Fiszman A, Alves-Leon SV, Nunes RG, D’Andea I, Figueira I. Traumatic events and posttraumatic stress disorder in patients with psychogenic nonepileptic seizures: a critical review. Epilepsy Behav. 2004;5:818–25.PubMedCrossRefGoogle Scholar
  41. 41.
    Chung MC, Allen RD. Alexithymia and posttraumatic stress disorder following epileptic seizure. Psychiatry Q. 2013;84(3):271–85.CrossRefGoogle Scholar
  42. 42.
    Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry. 1995;52:1048–60.PubMedCrossRefGoogle Scholar
  43. 43.
    Torta R, Keller R. Behavioral, psychotic, and anxiety disorders in epilepsy: etiology, clinical features, and therapeutic implications. Epilepsia. 1999;40 Suppl 10:S2–20.PubMedCrossRefGoogle Scholar
  44. 44.
    Filho GM, Rosa VP, Lin K, Caboclo LO, Sakamoto AC, Yacubian EM. Psychiatric comorbidity in epilepsy: a study comparing patients with mesial temporal sclerosis and juvenile myoclonic epilepsy. Epilepsy Behav. 2008;13(1):196–201.PubMedCrossRefGoogle Scholar
  45. 45.
    de Araujo Filho GM, da Silva JM, Mazetto L, Marchetti RL, Yacubian EM. Psychoses of epilepsy: a study comparing the clinical features of patients with focal versus generalized epilepsies. Epilepsy Behav. 2011;20(4):655–8.PubMedCrossRefGoogle Scholar
  46. 46.
    Kanner AM. Psychosis of epilepsy: a neurologist’s perspective. Epilepsy Behav. 2000;1:219–27.PubMedCrossRefGoogle Scholar
  47. 47.
    Kanner AM, Ostrovskaya A. Long-term significance of postictal psychotic episodes. I. Are they predictive of bilateral ictal foci? Epilepsy Behav. 2008;12:150–3.PubMedCrossRefGoogle Scholar
  48. 48.
    Kanemoto K, Kawasaki J, Mori E. Violence and epilepsy: a close relation between violence and postictal psychosis. Epilepsia. 1999;40(1):107–9.PubMedCrossRefGoogle Scholar
  49. 49.
    Kanemoto K, Tadokoro Y, Oshima T. Violence and postictal psychosis: a comparison of postictal psychosis, interictal psychosis, and postictal confusion. Epilepsy Behav. 2010;19(2):162–6.PubMedCrossRefGoogle Scholar
  50. 50.
    Alper KR, Barry JJ, Balabanov AJ. Treatment of psychosis, aggression, and irritability in patients with epilepsy. Epilepsy Behav. 2002;3(5S):13–8.PubMedCrossRefGoogle Scholar
  51. 51.
    Shah A, Carreno FR, Frazer A. Therapeutic modalities for treatment resistant depression: focus on vagal nerve stimulation and ketamine. Clin Psychopharmacol Neurosci. 2014;12(2):83–93.PubMedCentralPubMedCrossRefGoogle Scholar
  52. 52.
    Rhoton AL, O’Leary JL, Ferguson JP. The trigeminal, facial, vagal, and glossopharyngeal nerves in the monkey. Afferent connections. Arch Neurol. 1966;14(5):530–40.PubMedCrossRefGoogle Scholar
  53. 53.
    Kalia M, Sullivan JM. Brainstem projections of sensory and motor components of the vagus nerve in the rat. J Comp Neurol. 1982;211(3):248–65.PubMedCrossRefGoogle Scholar
  54. 54.
    Saper CB. Diffuse cortical projection systems: anatomical organization and role in cortical function. In: Plum F, editor. Handbook of physiology, section 1, vol. V. Washington, DC: American Physiological Society; 1987. p. 169–210.Google Scholar
  55. 55.
    Agostoni E, Chinnock JE, Daly MB, Murray JG. Functional and histological studies of the vagus nerve and its branches to the heart, lungs and abdominal viscera in the cat. J Physiol. 1957;135(1):182–205.PubMedCentralPubMedCrossRefGoogle Scholar
  56. 56.
    Henry TR. Therapeutic mechanisms of vagus nerve stimulation. Neurology. 2002;59 Suppl 4:S3–14.PubMedCrossRefGoogle Scholar
  57. 57.
    Boon P, Vonck K, Van Walleghem P, D’Havé M, Goossens L, Vandekerckhove T, et al. Programmed and magnet-induced vagus nerve stimulation for refractory epilepsy. J Clin Neurophysiol. 2001;18(5):402–7.PubMedCrossRefGoogle Scholar
  58. 58.
    Tatum WO, Helmers SL. Vagus nerve stimulation and magnet use: optimizing benefits. Epilepsy Behav. 2009;15(3):299–302.PubMedCrossRefGoogle Scholar
  59. 59.
    Elger G, Hoppe C, Falkai P, Rush AJ, Elger CE. Vagus nerve stimulation is associated with mood improvements in epilepsy patients. Epilepsy Res. 2000;42(2–3):203–10.PubMedCrossRefGoogle Scholar
  60. 60.
    Harden CL, Pulver MC, Ravdin LD, Nikolov B, Halper JP, Labar DR. A pilot study of mood in epilepsy patients treated with vagus nerve stimulation. Epilepsy Behav. 2000;1(2):93–9.PubMedCrossRefGoogle Scholar
  61. 61.
    Hoppe C, Helmstaedter C, Scherrmann J, Elger CE. Self-reported mood changes following 6 months of vagus nerve stimulation in epilepsy patients. Epilepsy Behav. 2001;2(4):335–42.PubMedCrossRefGoogle Scholar
  62. 62.
    Klinkenberg S, Majoie HJ, van der Heijden MM, Rijkers K, Leenen L, Aldenkamp AP. Vagus nerve stimulation has a positive effect on mood in patients with refractory epilepsy. Clin Neurol Neurosurg. 2012;114(4):336–40.PubMedCrossRefGoogle Scholar
  63. 63.
    Ramasubbu R, Taylor VH, Samaan Z, Sockalingham S, Li M, Patten S, et al. The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and select comorbid medical conditions. Ann Clin Psychiatry. 2012;24(1):91–109.PubMedGoogle Scholar
  64. 64.
    Blumer D, Davies K, Alexander A, Morgan S. Major psychiatric disorders subsequent to treating epilepsy by vagus nerve stimulation. Epilepsy Behav. 2001;2(5):466–72.PubMedCrossRefGoogle Scholar
  65. 65.
    Prater JF. Recurrent depression with vagus nerve stimulation. Am J Psychiatry. 2001;158(5):816–7.PubMedCrossRefGoogle Scholar
  66. 66.
    Keller S, Lichtenberg P. Psychotic exacerbation in a patient with seizure disorder treated with vagus nerve stimulation. Isr Med Assoc J. 2008;10(7):550–1.PubMedGoogle Scholar
  67. 67.
    Rush AJ, George MS, Sackeim HA, Marangell LB, Husain MM, Giller C, et al. Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study. Biol Psychiatry. 2000;47(4):276–86.PubMedCrossRefGoogle Scholar
  68. 68.
    Marangell LB, Rush AJ, George MS, Sackeim HA, Johnson CR, Husain MM, et al. Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes. Biol Psychiatry. 2002;51(4):280–7.PubMedCrossRefGoogle Scholar
  69. 69.
    Nahas Z, Marangell LB, Husain MM, Rush AJ, Sackeim HA, Lisanby SH, et al. Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes. J Clin Psychiatry. 2005;66(9):1097–104.PubMedCrossRefGoogle Scholar
  70. 70.
    Rush AJ, Marangell LB, Sackeim HA, George MS, Brannan SK, Davis SM, et al. Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial. Biol Psychiatry. 2005;58(5):347–54.PubMedCrossRefGoogle Scholar
  71. 71.
    Rush AJ, Sackeim HA, Marangell LB, George MS, Brannan SK, Davis SM, et al. Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study. Biol Psychiatry. 2005;58(5):355–63.PubMedCrossRefGoogle Scholar
  72. 72.
    Schlaepfer TE, Frick C, Zobel A, Maier W, Heuser I, Bajbouj M, et al. Vagus nerve stimulation for depression: efficacy and safety in a European study. Psychol Med. 2008;38(5):651–61.PubMedCrossRefGoogle Scholar
  73. 73.
    Bajbouj M, Merkl A, Schlaepfer TE, Frick C, Zobel A, Maier W, et al. Two-year outcome of vagus nerve stimulation in treatment-resistant depression. J Clin Psychopharmacol. 2010;30(3):273–81.PubMedCrossRefGoogle Scholar
  74. 74.
    Aaronson ST, Carpenter LL, Conway CR, Reimherr FW, Lisanby SH, Schwartz TL, et al. Vagus nerve stimulation therapy randomized to different amounts of electrical charge for treatment-resistant depression: acute and chronic effects. Brain Stimul. 2013;6(4):631–40.PubMedCrossRefGoogle Scholar
  75. 75.
    Conway CR, Colijn MA, Schachter SC. Vagus nerve stimulation for epilepsy and depression. In: Reti IM, editor. Brain stimulation: methodologies and interventions. Hoboken: John Wiley & Sons, Inc; 2015. p. 305–35.Google Scholar
  76. 76.
    Mauro MPS, Patronelli F, Spinelli E, Cordero A, Covello D, Gorostiaga JA. Nerves of the heart: a comprehensive review with a clinical point of view. Neuroanatomy. 2009;8(1):26–31.Google Scholar
  77. 77.
    Berry SM, Broglio K, Bunker M, Jayewardene A, Olin B, Rush AJ. A patient-level meta-analysis of studies evaluating vagus nerve stimulation therapy for treatment-resistant depression. Med Devices (Auckl). 2013;6:17–35.Google Scholar
  78. 78.
    Fanselow EE, Reid AP, Nicolelis MA. Reduction of pentylenetetrazol-induced seizure activity in awake rats by seizure-triggered trigeminal nerve stimulation. J Neurosci. 2000;20:8160–8.PubMedGoogle Scholar
  79. 79.
    DeGiorgio CM, Shewmon A, Murray D, Whitehurst T. Pilot study of trigeminal nerve stimulation (TNS) for epilepsy: a proof-of-concept trial. Epilepsia. 2006;47:1213–5.PubMedCrossRefGoogle Scholar
  80. 80.
    DeGiorgio CM, Soss J, Cook IA, Markovic D, Gornbein J, Murray D, et al. Randomized controlled trial of trigeminal nerve stimulation for drug-resistant epilepsy. Neurology. 2013;80:786–91.PubMedCentralPubMedCrossRefGoogle Scholar
  81. 81.
    Soss J, Heck C, Murray D, Markovic D, Oviedo S, Corrale-Leyva G, et al. A prospective long-term study of external trigeminal nerve stimulation for drug-resistant epilepsy. Epilepsy Behav. 2015;42:44–7.PubMedCrossRefGoogle Scholar
  82. 82.
    Schrader LM, Cook IA, Miller PR, Maremont ER, DeGiorgio CM. Trigeminal nerve stimulation in major depressive disorder: first proof of concept in an open pilot trial. Epilepsy Behav. 2011;22(3):475–8.PubMedCrossRefGoogle Scholar
  83. 83.
    Cook IA, Schrader LM, DeGiorgio CM, Miller PR, Maremont ER, Leuchter AF. Trigeminal nerve stimulation in major depressive disorder: acute outcomes in an open pilot study. Epilepsy Behav. 2013;28(2):221–6.PubMedCrossRefGoogle Scholar
  84. 84.
    Shiozawa P, da Silva ME, Netto GTM, Taiar I, Cordeiro Q. Effect of a 10-day trigeminal nerve stimulation (TNS) protocol for treating major depressive disorder: a phase II, sham-controlled, randomized clinical trial. Epilepsy Behav. 2015;44:23–6.PubMedCrossRefGoogle Scholar
  85. 85.
    Sandrini M, Umilta C, Rusconi E. The use of transcranial magnetic stimulation in cognitive neuroscience: a new synthesis of methodological issues. Neurosci Biobehav Rev. 2011;35:516–36.PubMedCrossRefGoogle Scholar
  86. 86.
    Lefaucheur JP, Andre-Obadia N, Antal A, Ayache SS, Baeken C, Benninger DH, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clin Neurophysiol. 2014;125:2150–206.PubMedCrossRefGoogle Scholar
  87. 87.
    CADTH Rapid Response Reports. Transcranial magnetic stimulation for the treatment of adults with PTSD, GAD, or depression: a review of clinical effectiveness and guidelines. Ottawa: Canadian Agency for Drugs and Technologies in Health; 2014. p. 1–44.Google Scholar
  88. 88.
    American Psychiatric Association. Practice guideline for the treatment of patients with major depressive disorder. Available at: http://psychiatryonline.org/pb/assets/raw/sitewide/practice_guidelines/guidelines/mdd.pdf. Accessed 18 Jan 2015.
  89. 89.
    Karsen EF, Watts BV, Holtzheimer PE. Review of the effectiveness of transcranial magnetic stimulation for post-traumatic stress disorder. Brain Stimul. 2014;7(2):151–7.PubMedCrossRefGoogle Scholar
  90. 90.
    Berlim MT, Van den Eynde F. Repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex for treating posttraumatic stress disorder: an exploratory meta-analysis of randomized, double-blind and sham-controlled trials. Can J Psychiatry. 2014;59(9):487–96.PubMedCentralPubMedGoogle Scholar
  91. 91.
    Bais M, Figee M, Denys D. Neuromodulation in obsessive-compulsive disorder. Psychiatr Clin North Am. 2014;37(3):393–413.PubMedCrossRefGoogle Scholar
  92. 92.
    Paes F, Baczynski T, Novaes F, Marinho T, Arias-Carrion O, Budde H, et al. Repetitive transcranial magnetic stimulation (rTMS) to treat social anxiety disorder: case reports and a review of the literature. Clin Pract Epidemiol Ment Health. 2013;9:180–8.PubMedCentralPubMedCrossRefGoogle Scholar
  93. 93.
    Cristancho MA, Cristancho P, O’Reardon JP. Other therapeutic psychiatric uses of superficial brain stimulation. Handb Clin Neurol. 2013;116:415–22.PubMedCrossRefGoogle Scholar
  94. 94.
    Stagg CJ, Nitsche MA. Physiological basis of transcranial direct current stimulation. Neuroscientist. 2011;17:37–53.PubMedCrossRefGoogle Scholar
  95. 95.
    David CN, Rapoport JL, Gogtay N. Treatments in context: transcranial direct current brain stimulation as a potential treatment in pediatric psychosis. Expert Rev Neurother. 2013;13(4):447–58.PubMedCentralPubMedCrossRefGoogle Scholar
  96. 96.
    Bennabi D, Pedron S, Haffen E, Monnin J, Peterschmitt Y, Van Waes V. Transcranial direct current stimulation for memory enhancement: from clinical research to animal models. Front Syst Neurosci. 2014;8:159.PubMedCentralPubMedCrossRefGoogle Scholar
  97. 97.
    Assenza G, Campana C, Formica D, Schena E, Taffoni F, Di Pino G, et al. Efficacy of cathodal transcranial direct current stimulation in drug-resistant epilepsy: a proof of principle. Conf Proc IEEE Eng Med Biol Soc. 2014;2014:530–3.PubMedGoogle Scholar
  98. 98.
    Auvichayapat N, Rotenberg A, Gersner R, Ngodklang S, Tiamkao S, Tassaneeyakul W, et al. Transcranial direct current stimulation for treatment of refractory childhood focal epilepsy. Brain Stimul. 2013;6(4):696–700.PubMedCrossRefGoogle Scholar
  99. 99.
    Berlim MT, Van den Eynde F, Daskalakis ZJ. Clinical utility of transcranial direct current stimulation (tDCS) for treating major depression: a systematic review and meta-analysis of randomized, double-blind and sham-controlled trials. J Psychiatr Res. 2013;47:1–7.PubMedCrossRefGoogle Scholar
  100. 100.
    Kalu UG, Sexton CE, Loo CK, Ebmeier KP. Transcranial direct current stimulation in the treatment of major depression: a meta-analysis. Psychol Med. 2012;42:1791–800.PubMedCrossRefGoogle Scholar
  101. 101.
    Shiozawa P, Fregni F, Bensenor IM, Lotufo PA, Berlim MT, Daskalakis JZ, et al. Transcranial direct current stimulation for major depression: an updated systematic review and meta-analysis. Int J Neuropsychopharmacol. 2014;17:1443–52.PubMedCrossRefGoogle Scholar
  102. 102.
    McIntyre CC, Savasta M, Kerkerian-Le Goff L, Vitek JL. Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both. Clin Neurophysiol. 2004;115:1239–48.PubMedCrossRefGoogle Scholar
  103. 103.
    Iremonger KJ, Anderson TR, Hu B, Kiss ZH. Cellular mechanisms preventing sustained activation of cortex during subcortical high-frequency stimulation. J Neurophysiol. 2006;96:613–21.PubMedCrossRefGoogle Scholar
  104. 104.
    Chiken S, Nambu A. Disrupting neuronal transmission: mechanism of DBS? Front Syst Neurosci. 2014;8:33.PubMedCentralPubMedCrossRefGoogle Scholar
  105. 105.
    Fisher RS, Velasco AL. Electrical brain stimulation for epilepsy. Nat Rev Neurol. 2014;10:261–70.PubMedCrossRefGoogle Scholar
  106. 106.
    Cox JH, Seri S, Cavanna AE. Clinical utility of implantable neurostimulation devices as adjunctive treatment of uncontrolled seizures. Neuropsychiatr Dis Treat. 2014;10:2191–200.PubMedCentralPubMedGoogle Scholar
  107. 107.
    Heck C, King-Stephens D, Massey A, Nair D, Jobst B, Barkley G, et al. Responsive neurostimulation: the hope and the challenges. Epilepsy Curr. 2014;14:270–1.CrossRefGoogle Scholar
  108. 108.
    Fisher R, Salanova V, Witt T, Worth R, Henry T, Gross R, et al. Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy. Epilepsia. 2010;51(5):899–908.PubMedCrossRefGoogle Scholar
  109. 109.
    Delaloye S, Holtzheimer PE. Deep brain stimulation in the treatment of depression. Dialoques Clin Neurosci. 2014;16(1):83–91.Google Scholar
  110. 110.
    Medtronic. About deep brain stimulation for psychiatric disorders. Available at: https://professional.medtronic.com/pt/neuro/dbs-pd/edu/about/index.htm#tabs-1. Accessed 18 Jan 18 2015.
  111. 111.
    Castrioto A, Lhommee E, Moro E, Krack P. Mood and behavioural effects of subthalamic stimulation in Parkinson’s disease. Lancet Neurol. 2014;13(3):287–305.PubMedCrossRefGoogle Scholar
  112. 112.
    Sun FT, Morrell MJ. Closed-loop neurostimulation: the clinical experience. Neurotherapeutics. 2014;11:553–63.PubMedCentralPubMedCrossRefGoogle Scholar
  113. 113.
    Morrell MJ, RNS System in Epilepsy Study Group. Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology. 2011;77(13):1295–304.PubMedCrossRefGoogle Scholar
  114. 114.
    Heck C, King-Stephens D, Massey A, Nair D, Jobst B, Barkley G, et al. Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: final results of the RNS System Pivotal trial. Epilepsia. 2014;55(3):432–41.PubMedCentralPubMedCrossRefGoogle Scholar
  115. 115.
    Meador KJ, Kapur R, Loring DW, Kanner AM, Morrell MJ, the RNS System Pivotal Trial Investigators. Quality of life and mood in patients with medically intractable epilepsy treated with targeted responsive neurostimulation. Epilepsy Behav. 2015;45:242–7.PubMedCrossRefGoogle Scholar
  116. 116.
    Kavirajan HC, Lueck K, Chuang, K. Alternating current cranial electrotherapy stimulation (CES) for depression. Cochrane Database Syst Rev. 2014;(7):CD010521.Google Scholar
  117. 117.
    Cyberonics, Inc. Available at: http://ir.cyberonics.com/releasedetail.cfm?ReleaseID=826981. Accessed 18 Jan 2015.

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Departments of NeurologyConsortia for Improving Medicine with Innovation and Technology, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Harvard Medical SchoolBostonUSA

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